Výsledky vyhledávání - "Namini Paranawithana"

Manganese(II)-Based Responsive Contrast Agent Detects Glucose-Stimulated Zinc Secretion from the Mouse Pancreas and Prostate by MRI

Autor: André F. T. Martins, Sara Chirayil, Namini Paranawithana, S. James Ratnakar, A. Dean Sherry, Veronica Clavijo Jordan

Publikováno v: Inorg Chem

A Mn(II)-based zinc-sensitive MRI contrast agent, MnPyC3A–BPEN, was prepared, characterized, and applied in imaging experiments to detect glucose-stimulated zinc secretion (GSZS) from the mouse pancreas and prostate in vivo. Thermodynamic and kinet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f0973f76d033e5669156b0f06c03dc5
https://pubmed.ncbi.nlm.nih.gov/33507742

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A manganese(II)-Based Responsive Contrast Agent Detects Glucose- Stimulated Zinc Secretion from the Mouse Pancreas and Prostate by MRI

Autor: Sara Chirayil, Veronica Clavijo-Jordan, Andre F. Martins, Namini Paranawithana, James Soundrarajan, Dean Sherry

A Mn(II)-based zinc-sensitive MRI contrast agent, Mn(PyC3A)-BPEN, was prepared and characterized and the agent was used in imaging experiments to detect glucose-stimulated zinc secretion (GSZS) from the mouse pancreas and prostate in vivo. Thermodyna

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a417cf6314318067b502347d0a41797e
https://doi.org/10.26434/chemrxiv.12430082

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A Responsive Magnetic Resonance Imaging Contrast Agent for Detection of Excess Copper(II) in the Liver In Vivo

Autor: Sara Chirayil, Namini Paranawithana, Piyu Zhao, André F. Martins, Gabriele Meloni, Veronica Clavijo Jordan, A. Dean Sherry

Publikováno v: J Am Chem Soc

The design, synthesis, and properties of a new gadolinium-based copper-responsive magnetic resonance imaging (MRI) contrast agent is presented. The sensor (GdL(1)) has high selectivity for copper ions and exhibits a 43% increase in r(1) relaxivity (2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5236ddbf41a2fac48275bf58cce6a87a
https://europepmc.org/articles/PMC9991518/

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Imaging Insulin Secretion from Mouse Pancreas by MRI Is Improved by Use of a Zinc-Responsive MRI Sensor with Lower Affinity for Zn

Autor: André F, Martins, Veronica, Clavijo Jordan, Filip, Bochner, Sara, Chirayil, Namini, Paranawithana, Shanrong, Zhang, Su-Tang, Lo, Xiaodong, Wen, Piyu, Zhao, Michal, Neeman, A Dean, Sherry

Publikováno v: Journal of the American Chemical Society. 140(50)

It has been demonstrated that divalent zinc ions packaged with insulin in β-cell granules can be detected by MRI during glucose-stimulated insulin secretion using a gadolinium-based Zn(2+)-sensitive agent. This study was designed to evaluate whether

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f2b7346f0bcd7ee2b2ed9cbb8891a811
https://pubmed.ncbi.nlm.nih.gov/30484648

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A Responsive MRI Contrast Agent for Detection of Excess copper(II) in the Liver in Vivo

Autor: Namini Paranawithana, André F. Martins, Sara Chirayil, Gabriele Meloni, Dean Sherry, Veronica Clavijo-Jordan, Piyu Zhao

The design, synthesis, and properties of a new gadolinium-based copper-responsive MRI contrast agents are presented in detail here. The sensor (GdL1) has high selectivity for copper ions and exhibits a 47% increase in r1 relaxivity upon binding to 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad45de3a5eb5da2f2c11fffab1b25466
https://doi.org/10.26434/chemrxiv.7359095

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