The GHB analogue HOCPCA improves deficits in cognition and sensorimotor function after MCAO via CaMKIIα.

Autor: Griem-Krey N; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark., Klein AB; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Clausen BH; Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.; Brain Research Inter-Disciplinary Guided Excellence (BRIDGE), Department of Clinical Research, University of Southern Denmark, Odense, Denmark., Namini MR; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark., Nielsen PV; Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark., Bhuiyan M; Department of Anatomy, Brain Health Research Centre and Brain Research New Zealand, University of Otago, Dunedin, New Zealand., Nagaraja RY; Department of Anatomy, Brain Health Research Centre and Brain Research New Zealand, University of Otago, Dunedin, New Zealand., De Silva TM; Department of Microbiology, Anatomy, Physiology & Pharmacology and Centre for Cardiovascular Biology and Disease Research, School of Agriculture, Biomedicine & Environment, La Trobe University, Bundoora, Australia., Sobey CG; Department of Microbiology, Anatomy, Physiology & Pharmacology and Centre for Cardiovascular Biology and Disease Research, School of Agriculture, Biomedicine & Environment, La Trobe University, Bundoora, Australia., Cheng HC; Department of Biochemistry and Pharmacology, University of Melbourne, Parkville, Australia.; Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Australia., Orset C; Physiopathology and Imaging of Neurological Disorders, University of Caen Normandy, Caen, France., Vivien D; Physiopathology and Imaging of Neurological Disorders, University of Caen Normandy, Caen, France., Lambertsen KL; Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.; Brain Research Inter-Disciplinary Guided Excellence (BRIDGE), Department of Clinical Research, University of Southern Denmark, Odense, Denmark., Clarkson AN; Department of Anatomy, Brain Health Research Centre and Brain Research New Zealand, University of Otago, Dunedin, New Zealand.; Department of Microbiology, Anatomy, Physiology & Pharmacology and Centre for Cardiovascular Biology and Disease Research, School of Agriculture, Biomedicine & Environment, La Trobe University, Bundoora, Australia., Wellendorph P; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.

Publikováno v: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism [J Cereb Blood Flow Metab] 2023 Aug; Vol. 43 (8), pp. 1419-1434. Date of Electronic Publication: 2023 Apr 07.