Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Namgyu, Lee"'
Publikováno v:
Biomimetics, Vol 9, Iss 9, p 547 (2024)
Neuromorphic devices are electronic devices that mimic the information processing methods of neurons and synapses, enabling them to perform multiple tasks simultaneously with low power consumption and exhibit learning ability. However, their large-sc
Externí odkaz:
https://doaj.org/article/b9199125d1db4332b01ff3872025d35c
Autor:
Namgyu Lee, Dohoon Kim
Publikováno v:
Metabolites, Vol 12, Iss 6, p 527 (2022)
In inborn errors of metabolism, such as amino acid breakdown disorders, loss of function mutations in metabolic enzymes within the catabolism pathway lead to an accumulation of the catabolic intermediate that is the substrate of the mutated enzyme. I
Externí odkaz:
https://doaj.org/article/165ac1f01f024739ac1b64e919edd4b9
Autor:
Chuangqi Wang, Hee June Choi, Sung-Jin Kim, Aesha Desai, Namgyu Lee, Dohoon Kim, Yongho Bae, Kwonmoo Lee
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Cell protrusion dynamics are heterogeneous at the subcellular level, but current analyses operate at the cellular or ensemble level. Here the authors develop a computational framework to quantify subcellular protrusion phenotypes and reveal the under
Externí odkaz:
https://doaj.org/article/57f2a6977c8741f1bc29a2854eb06218
Autor:
Sung Jin Park, Su Been Lee, Yeongjun Suh, Su-Jeong Kim, Namgyu Lee, Ji-Ho Hong, Cana Park, Youngsik Woo, Koko Ishizuka, Joung-Hun Kim, Per-Olof Berggren, Akira Sawa, Sang Ki Park
Publikováno v:
Cell Reports, Vol 21, Iss 10, Pp 2748-2759 (2017)
Summary: A wide range of Ca2+-mediated functions are enabled by the dynamic properties of Ca2+, all of which are dependent on the endoplasmic reticulum (ER) and mitochondria. Disrupted-in-schizophrenia 1 (DISC1) is a scaffold protein that is involved
Externí odkaz:
https://doaj.org/article/42f92d4ae5674557819ad6f2063d93e1
Autor:
Hoe-Yune Jung, Dongyeop Lee, Hye Guk Ryu, Bo-Hwa Choi, Younghoon Go, Namgyu Lee, Dohyun Lee, Heehwa G. Son, Jongsu Jeon, Seong-Hoon Kim, Jong Hyuk Yoon, Seon-Min Park, Seung-Jae V. Lee, In-Kyu Lee, Kwan Yong Choi, Sung Ho Ryu, Kazunari Nohara, Seung-Hee Yoo, Zheng Chen, Kyong-Tai Kim
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Robust mitochondrial respiration provides energy to support physical performance and physiological well-being, whereas mitochondrial malfunction is associated with various pathologies and reduced longevity. In the current study, we tested wh
Externí odkaz:
https://doaj.org/article/10201d00788242438ead92d92999e6dd
Autor:
Namgyu Lee, Sung Jin Park, Mike Lange, Tenzin Tseyang, Mihir B. Doshi, Tae Yong Kim, Yoseb Song, Dong In Kim, Paul L. Greer, James A. Olzmann, Jessica B. Spinelli, Dohoon Kim
The canonical biological function of selenium is in the production of selenocysteine residues of selenoproteins, and this forms the basis for its role as an essential antioxidant and cytoprotective micronutrient. Here, we demonstrate that selenium, v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::238be02ad131d1d3798fc4e04a2721d0
https://doi.org/10.1101/2023.04.13.535674
https://doi.org/10.1101/2023.04.13.535674
Autor:
Namgyu Lee, Anne E. Carlisle, Austin Peppers, Sung Jin Park, Mihir B. Doshi, Meghan E. Spears, Dohoon Kim
Publikováno v:
Antioxidants, Vol 10, Iss 2, p 317 (2021)
Inducers of ferroptosis such as the glutathione depleting agent Erastin and the GPX4 inhibitor Rsl-3 are being actively explored as potential therapeutics in various cancers, but the factors that determine their sensitivity are poorly understood. Her
Externí odkaz:
https://doaj.org/article/c4bcf470047a4386b238a23b4b45711d
Autor:
Namgyu Lee, Hye Guk Ryu, Jung-Hee Kwon, Dae-Kyum Kim, Sae Rom Kim, Hee Jung Wang, Kyong-Tai Kim, Kwan Yong Choi
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0165835 (2016)
The role of Sirtuin 6 (SIRT6) as a tumor suppressor or oncogene in liver cancer remains controversial. Thus, we identified the specific role of SIRT6 in the progression of hepatocellular carcinoma (HCC). SIRT6 expression was significantly higher in H
Externí odkaz:
https://doaj.org/article/a340a91331c641588bf59444fa79f74d
Publikováno v:
Oncogene
It is well recognized that many metabolic enzymes play essential roles in cancer cells in producing building blocks such as nucleotides, which are required in greater amounts due to their increased proliferation. On the other hand, the significance o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e587ae6b03f12c169a520c453d0b5450
https://doi.org/10.1038/s41388-020-01395-9
https://doi.org/10.1038/s41388-020-01395-9
Publikováno v:
Methods in enzymology. 662
The production of selenoproteins in cancer cells is dependent on uptake of selenium and processing via the selenocysteine biosynthesis pathway. Both the uptake and processing of selenium has recently shown to be upregulated in subsets of cancer cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7e7f7323905d444c484983d9b13d5d0e
https://pubmed.ncbi.nlm.nih.gov/35101206
https://pubmed.ncbi.nlm.nih.gov/35101206