Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Nambu, Mitchell"'
Autor:
Mehdi Michel Djamel Numa, Molly K. Moloney, Nambu Mitchell David, Robert R. Webb, Michael Trzoss, Mili Kapoor, Jonathan A. Covel, Quinlyn A. Soltow, Mitchell Mutz, Xiaoming Li, Peter J. Webb
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:2465-2471
A novel antifungal strategy targeting the inhibition of calcineurin is described. To develop a calcineurin based inhibitor of pathogenic fungi, analogs of FK506 were synthesized that were able to permeate mammalian but not fungal cells. Antagonists i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e21264582bc6932ed420f6836aaa6ac4
https://doi.org/10.1016/j.bmcl.2017.04.004
https://doi.org/10.1016/j.bmcl.2017.04.004
Autor:
Nambu, Mitchell, Covel, Jonathan A., Kapoor, Mili, Li, Xiaoming, Moloney, Molly K., Numa, Mehdi M., Soltow, Quinlyn A., Trzoss, Michael, Webb, Peter, Webb, Robert R., II, Mutz, Mitchell
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 1 June 2017 27(11):2465-2471
Autor:
Gilles H. Goetz, Michele McTigue, Max Parker, Ya-Li Deng, Nambu Mitchell David, J. Jean Cui, Shinji Yamazaki, Jia Lei, Neil Grodsky, Shirley A. Aguirre, Jacqui Elizabeth Hoffman, Kevin Ryan, Hong Shen, Phuong Le, Sergei Timofeevski, James G. Christensen, Helen Y. Zou, Cheng Hengmiao, Brion W. Murray, Michelle Tran-Dubé, Mehran Jalaie, Qiuhua Li, Pairish Mason Alan
Publikováno v:
Journal of Medicinal Chemistry. 55:8091-8109
The c-MET receptor tyrosine kinase is an attractive oncology target because of its critical role in human oncogenesis and tumor progression. An oxindole hydrazide hit 6 was identified during a c-ME...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a253c3b903e7bc7ae29a14c9a9b40dd
https://doi.org/10.1021/jm300967g
https://doi.org/10.1021/jm300967g
Autor:
Michelle Tran-Dubé, Helen Y. Zou, Hong Shen, Neil Grodsky, James G. Christensen, Max Parker, Nambu Mitchell David, Michele McTigue, Shirley A. Aguirre, Qiuhua Li, Kevin Ryan, Shinji Yamazaki, J. Jean Cui
Publikováno v:
Journal of medicinal chemistry. 56(17)
The hepatocyte growth factor (HGF)/c-Met signaling axis is deregulated in many cancers and plays important roles in tumor invasive growth and metastasis. An exclusively selective c-Met inhibitor (S)-6-(1-(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6125b1651a89085c6c5ec00da0b84d80
https://pubmed.ncbi.nlm.nih.gov/23944843
https://pubmed.ncbi.nlm.nih.gov/23944843
Autor:
Michele McTigue, Robert Steven Kania, Pei-Pei Kung, Nambu Mitchell David, Jerry Meng, Steve Bender, Barbara Mroczkowski, Botrous Iriny, J. Jean Cui, Shinji Yamazaki, Pairish Mason Alan, Hong Shen, Jia Lei, James G. Christensen, Sergei Timofeevski, Gordon Alton, Michelle Tran-Dubé, Ellen Padrique, Qiuhua Li, Funk Lee Andrew, Helen Y. Zou, Martin Paul Edwards, Neil Grodsky, Kevin Ryan
Publikováno v:
Journal of medicinal chemistry. 54(18)
Because of the critical roles of aberrant signaling in cancer, both c-MET and ALK receptor tyrosine kinases are attractive oncology targets for therapeutic intervention. The cocrystal structure of 3 (PHA-665752), bound to c-MET kinase domain, reveale
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eddb1abcb2ee10bdd59cbe8b21fe5e2f
https://pubmed.ncbi.nlm.nih.gov/21812414
https://pubmed.ncbi.nlm.nih.gov/21812414
Autor:
Zhengyu Liu, Haitao Wang, Bernadette Pascual, Jing Yuan, Dan Knighton, Shubha Bagrodia, Simon Bailey, Graham L. Smith, Caroline Rodgers, Lisa Gao, Yang Anle, Cheng Hengmiao, Kevin K.-C. Liu, Jacqui Elizabeth Hoffman, Kristina Rafidi, Shaoxian Sun, Samantha Elizabeth Greasley, Aihua Zou, Sacha Ninkovic, Hui Chen, Nambu Mitchell David, Matthew A. Marx, Qiyue Hu, Theodore O. Johnson
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(20)
Pteridinones were designed based on a non-selective kinase template. Because of the uniqueness of the PI3K and mTOR binding pockets, a methyl group was introduced to C-4 position of the peteridinone core to give compounds with excellent selectivity f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a262ab6883facc613c34a51c5d278d86
https://pubmed.ncbi.nlm.nih.gov/20817449
https://pubmed.ncbi.nlm.nih.gov/20817449
Autor:
Nambu Mitchell David, Pei Pei Kung, Gerrit Los, Bender Steven Lee, Helen Y. Zou, James G. Christensen, Scott Rp McDonnell, Barbara Mroczkowski, Joseph H. Lee, Gordon Alton, Qiuhua Li, Shinji Yamazaki, Maria E. Arango, Tatiana B. Koudriakova, Jingrong Jean Cui
Publikováno v:
Cancer research. 67(9)
The c-Met receptor tyrosine kinase and its ligand, hepatocyte growth factor (HGF), have been implicated in the progression of several human cancers and are attractive therapeutic targets. PF-2341066 was identified as a potent, orally bioavailable, AT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40d560db97941edf90a251ad1d3434d9
https://pubmed.ncbi.nlm.nih.gov/17483355
https://pubmed.ncbi.nlm.nih.gov/17483355
Autor:
Liu, Kevin K.-C., Bagrodia, Shubha, Bailey, Simon, Cheng, Hengmiao, Chen, Hui, Gao, Lisa, Greasley, Samantha, Hoffman, Jacqui E., Hu, Qiyue, Johnson, Ted O., Knighton, Dan, Liu, Zhengyu, Marx, Matthew A., Nambu, Mitchell D., Ninkovic, Sacha, Pascual, Bernadette, Rafidi, Kristina, Rodgers, Caroline M.-L., Smith, Graham L., Sun, Shaoxian, Wang, Haitao, Yang, Anle, Yuan, Jing, Zou, Aihua
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 2010 20(20):6096-6099
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Akademický článek
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