The hydrophobicity of the CARD8 N-terminus tunes inflammasome activation.

Autor: Tsamouri LP; Pharmacology Program of the Weill Cornell Graduate School of Medical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Hsiao JC; Pharmacology Program of the Weill Cornell Graduate School of Medical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Wang Q; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Geeson MB; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Huang HC; Tri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Nambiar DR; Tri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Zou M; Biochemistry, Structural, Cell, Developmental and Molecular Biology Allied Program, Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, New York, NY, USA., Ball DP; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Chui AJ; Tri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Bachovchin DA; Pharmacology Program of the Weill Cornell Graduate School of Medical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Tri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: bachovcd@mskcc.org.

Publikováno v: Cell chemical biology [Cell Chem Biol] 2024 Sep 19; Vol. 31 (9), pp. 1699-1713.e8. Date of Electronic Publication: 2024 Jul 10.