Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Namakkal S Rajasekaran"'
Autor:
Arun Jyothidasan, Sini Sunny, Asokan Devarajan, Aniqa Sayed, John Kofi Afortude, Brian Dalley, Vivek Nanda, Steven Pogwizd, Silvio H. Litovsky, Joel D. Trinity, Matthew Might, Namakkal S. Rajasekaran
Publikováno v:
Redox Biology, Vol 75, Iss , Pp 103263- (2024)
The endoplasmic reticulum (ER) regulates protein folding and maintains proteostasis in cells. We observed that the ER transcriptome is impaired during chronic reductive stress (RS) in cardiomyocytes. Here, we hypothesized that a prolonged moderate tr
Externí odkaz:
https://doaj.org/article/89d8b21237c04432b90821ae7822b5b0
Autor:
Heng B Xie, Anthony Cammarato, Namakkal S Rajasekaran, Huali Zhang, Jennifer A Suggs, Ho-Chen Lin, Sanford I Bernstein, Ivor J Benjamin, Kent G Golic
Publikováno v:
PLoS Genetics, Vol 9, Iss 6, p e1003544 (2013)
Dominant mutations in the alpha-B crystallin (CryAB) gene are responsible for a number of inherited human disorders, including cardiomyopathy, skeletal muscle myopathy, and cataracts. The cellular mechanisms of disease pathology for these disorders a
Externí odkaz:
https://doaj.org/article/4789041d94c142bda94469f8185de730
Autor:
Sellamuthu S Gounder, Sankaranarayanan Kannan, Dinesh Devadoss, Corey J Miller, Kevin J Whitehead, Shannon J Odelberg, Matthew A Firpo, Robert Paine, John R Hoidal, E Dale Abel, Namakkal S Rajasekaran
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45697 (2012)
Aging promotes accumulation of reactive oxygen/nitrogen species (ROS/RNS) in cardiomyocytes, which leads to contractile dysfunction and cardiac abnormalities. These changes may contribute to increased cardiovascular disease in the elderly. Inducible
Externí odkaz:
https://doaj.org/article/38dbd9b2c38f4a88bbbf5e2c32c1477f
Autor:
S. Mohd. Shiraz Rizvi, Sini Sunny, Irshad A. Wani, Farzana Mahdi, Zeeshan H. Zaidi, Namakkal S. Rajasekaran
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
Assessing regional wall motion abnormalities (RWMA) in the myocardium may provide early diagnosis and treat chronic remodeling in STEMI patients. We assessed RWMA in 217 subjects with anterior STEMI admitted to Era University Hospital in Lucknow, UP,
Externí odkaz:
https://doaj.org/article/00584dadaf5a4c6eb9cd5d858605004d
Autor:
Muralidharan Thoddi Ramamurthy, Vinod Kumar Balakrishnan, Sini Sunny, Abinayaa Rajkumar, Sandhya Sundaram, Preetam Krishnamurthy, Nagendra Boopathy Senguttuvan, Arunan Murali, J. D. Roy Santhosham, Kalaiselvi Periandavan, Namakkal S. Rajasekaran
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2023)
The reported incidence of liposarcomas in ~2,000 cases annually results in about 30% of myxoid liposarcomas. Cardiac myoxid liposarcomas are very rare; their presentation could be cardiac tamponade, due to direct compression of the tumor and/or peric
Externí odkaz:
https://doaj.org/article/6121db0e37b24258ab10dcf4886aa0cb
Autor:
Sini Sunny, Arun Jyothidasan, Cynthia L. David, Krishna Parsawar, Arul Veerappan, Dean P. Jones, Steven Pogwizd, Namakkal S. Rajasekaran
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Nuclear factor erythroid 2-related factor 2 (NRF2), a redox sensor, is vital for cellular redox homeostasis. We reported that transgenic mice expressing constitutively active Nrf2 (CaNrf2-TG) exhibit reductive stress (RS). In this study, we identifie
Externí odkaz:
https://doaj.org/article/6f46c3b363dc403288078fd580f7ae56
Publikováno v:
Redox Biology, Vol 34, Iss , Pp 101492- (2020)
Myo-satellite cells regenerate and differentiate into skeletal muscle (SM) after acute or chronic injury. Changes in the redox milieu towards the oxidative arm at the wound site are known to compromise SM regeneration. Recently, we reported that abro
Externí odkaz:
https://doaj.org/article/6ad0f9b98dcc4cf996ab6ea3987cae9d
Autor:
Justin M. Quiles, Madhusudhanan Narasimhan, Timothy Mosbruger, Gobinath Shanmugam, David Crossman, Namakkal S. Rajasekaran
Publikováno v:
Redox Biology, Vol 13, Iss C, Pp 568-580 (2017)
The nuclear factor erythroid 2 like 2 (Nfe2l2/Nrf2) is a master regulator of antioxidant gene transcription. We recently identified that constitutive activation of Nrf2 (CaNrf2) caused reductive stress (RS) in the myocardium. Here we investigate how
Externí odkaz:
https://doaj.org/article/5ef54726c8fc4d75ac0f1f63b1e17485
Autor:
Gobinath Shanmugam, Madhusudhanan Narasimhan, Susan Tamowski, Victor Darley-Usmar, Namakkal S. Rajasekaran
Publikováno v:
Redox Biology, Vol 12, Iss , Pp 937-945 (2017)
Redox homeostasis regulates key cellular signaling pathways in both physiology and pathology. The cell's antioxidant response provides a defense against oxidative stress and establishes a redox tone permissive for cell signaling. The molecular regula
Externí odkaz:
https://doaj.org/article/1067ea5776484630b9f17338bb52afbf
Autor:
Sini Sunny, Namakkal S. Rajasekaran, Justin M. Quiles, Adam R. Wende, Sandeep B. Shelar, Steven M. Pogwizd, John R. Hoidal, Brian Dalley, Mark E Pepin, Anil K. Challa
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
Although recent advances in the treatment of acute coronary heart disease have reduced mortality rates, few therapeutic strategies exist to mitigate the progressive loss of cardiac function that manifests as heart failure. Nuclear factor, erythroid 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf2a800252cdf9a1b96daebc480b9d68
https://doaj.org/article/0bacb871034845faa009f27435e581fe
https://doaj.org/article/0bacb871034845faa009f27435e581fe