Zobrazeno 1 - 10
of 224
pro vyhledávání: '"Nam-Jung Kim"'
Identification of novel pyrrolopyrimidine and pyrrolopyridine derivatives as potent ENPP1 inhibitors
Autor:
Hee Jin Jeong, Hye Lim Lee, Sung Joon Kim, Jeong Hyun Jeong, Su Hyun Ji, Han Byeol Kim, Miso Kang, Hwan Won Chung, Chan Sun Park, Hyunah Choo, Hyo Jae Yoon, Nam-Jung Kim, Duck-Hyung Lee, Sanghee Lee, Seo-Jung Han
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2434-2451 (2022)
In an effort to discover novel scaffolds of non-nucleotide-derived Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) inhibitors to stimulate the Stimulator of Interferon Genes (STING) pathway, we designed and synthesised pyrrolopyrimidine an
Externí odkaz:
https://doaj.org/article/d4014599d664477e9c2a28b353c2de49
Autor:
Eunbi Cho, Kumju Youn, Huiyoung Kwon, Jieun Jeon, Wan-Seob Cho, Se Jin Park, Seung Hwan Son, Dae Sik Jang, Chan Young Shin, Minho Moon, Mira Jun, Nam-Jung Kim, Dong Hyun Kim
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 148, Iss , Pp 112763- (2022)
Alzheimer’s disease (AD) is caused by various pathological mechanisms; therefore, it is necessary to develop drugs that simultaneously act on multiple targets. In this study, we investigated the effects of eugenitol, which has anti-amyloid β (Aβ)
Externí odkaz:
https://doaj.org/article/0d0b2c4c58944feb914eedbb8f70c7a7
Autor:
Min Sung Gee, Seung Hwan Son, Seung Ho Jeon, Jimin Do, Namkwon Kim, Yeon-Joo Ju, Soo Jin Lee, Eun Kyoung Chung, Kyung-Soo Inn, Nam-Jung Kim, Jong Kil Lee
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-18 (2020)
Abstract Background Chronic neuroinflammation, aggressive amyloid beta (Aβ) deposition, neuronal cell loss, and cognitive impairment are pathological presentations of Alzheimer’s disease (AD). Therefore, resolution of neuroinflammation and inhibit
Externí odkaz:
https://doaj.org/article/b1ea94564d774370a4ff5064f7f2dfe3
Autor:
Jayeong Kim, Yujin Jang, Nam-Jung Kim, Heehun Kim, Gyu-Chul Yi, Yukyung Shin, Myung Hwa Kim, Seokhyun Yoon
Publikováno v:
Frontiers in Chemistry, Vol 7 (2019)
Surface enhanced Raman spectroscopy (SERS) has been intensively investigated during the past decades for its enormous electromagnetic field enhancement near the nanoscale metallic surfaces. Chemical enhancement of SERS, however, remains rather elusiv
Externí odkaz:
https://doaj.org/article/2643262518674b9e917ac3347c47051d
Autor:
Ga Yeong Kim, Chae Won Song, Yo-Sep Yang, Na-Rae Lee, Hyung-Seok Yoo, Seung Hwan Son, Soo Jin Lee, Jong Seon Park, Jong Kil Lee, Kyung-Soo Inn, Nam-Jung Kim
Publikováno v:
Molecules, Vol 26, Iss 9, p 2525 (2021)
A series of PROTACs (PROteolysis-TArgeting Chimeras) consisting of bicalutamide analogs and thalidomides were designed, synthesized, and biologically evaluated as novel androgen receptor (AR) degraders. In particular, we found that PROTAC compound 13
Externí odkaz:
https://doaj.org/article/32dd86b792cc47b8baed18485d0d87de
Autor:
Eun-Hee Kim, Su-Jung Kim, Hye-Kyung Na, Wonshik Han, Nam-Jung Kim, Young-Ger Suh, Young-Joon Surh
Publikováno v:
Cells, Vol 10, Iss 3, p 526 (2021)
There is a plethora of evidence to support that inflammation is causally linked to carcinogenesis. Cyclooxygenase-2 (COX-2), a rate-limiting enzyme in the biosynthesis of prostaglandins, is inappropriately overexpressed in various cancers and hence r
Externí odkaz:
https://doaj.org/article/904ad8e0ea2347df80f2dc4622ad84b5
Publikováno v:
Molecules, Vol 23, Iss 10, p 2417 (2018)
4-Arylcoumarins (4-aryl-2H-1-benzopyran-2-one), also known as neoflavones, comprise a minor subclass of naturally occurring flavonoids. Because of their broad-spectrum biological activities, arylcoumarins have been attracting the attention of the org
Externí odkaz:
https://doaj.org/article/7a60f55aa22d4cb4929b351a2e024d13
Autor:
Suk In Park, Youngbin Tchoe, Hyeonjun Baek, Jaehyuk Heo, Jerome K. Hyun, Janghyun Jo, Miyoung Kim, Nam-Jung Kim, Gyu-Chul Yi
Publikováno v:
APL Materials, Vol 3, Iss 1, Pp 016103-016103-6 (2015)
We report the growth of high-quality, smooth, and flat ZnO thin films on graphene layers and their photoluminescence (PL) characteristics. For the growth of high-quality ZnO thin films on graphene layers, ZnO nanowalls were grown using metal-organic
Externí odkaz:
https://doaj.org/article/8ab241a0bf464742bdebd6a3ca874dbc
Autor:
Jong Kil Lee, Nam-Jung Kim
Publikováno v:
Molecules, Vol 22, Iss 8, p 1287 (2017)
P38 mitogen-activated protein kinase (MAPK) is a crucial target for chronic inflammatory diseases. Alzheimer’s disease (AD) is characterized by the presence of amyloid plaques and neurofibrillary tangles in the brain, as well as neurodegeneration,
Externí odkaz:
https://doaj.org/article/6ebf70d073be42c3865ee681fe7423c2
Autor:
Seung Hwan Son, Na-Rae Lee, Min Sung Gee, Chae Won Song, Soo Jin Lee, Sang-Kyung Lee, Yoonji Lee, Hee Jin Kim, Jong Kil Lee, Kyung-Soo Inn, Nam-Jung Kim
Publikováno v:
ACS Central Science. 9:417-426