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Akademický článek

Application of a Thermo-Reversible Gelation Polymer, Mebiol Gel, for Stem Cell Culture and Regenerative Medicine

Autor: Nam-ho Huh, Ken Kataoka

Publikováno v: Journal of Stem Cells and Regenerative Medicine, Vol 6, Iss 1, Pp 10-14 (2010)

Recent studies have revealed the possible utility of a three-dimensional culture system using a thermo-reversible gelation polymer, Mebiol Gel. It is a purely synthesized biocompatible copolymer composed of thermoresponsive polymer blocks [poly(N-iso

Externí odkaz: https://doaj.org/article/ea08fdd4ca1a42c59b183f71c2fbb5ea

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Akademický článek

NRF2 Regulates PINK1 Expression under Oxidative Stress Conditions.

Autor: Hitoshi Murata, Hitoshi Takamatsu, Sulai Liu, Ken Kataoka, Nam-Ho Huh, Masakiyo Sakaguchi

Publikováno v: PLoS ONE, Vol 10, Iss 11, p e0142438 (2015)

Mutations of the PTEN-induced putative kinase 1 (PINK1) gene are a cause of autosomal recessive forms of Parkinson's disease. Recent studies have revealed that PINK1 is an essential factor for controlling mitochondrial quality, and that it protects c

Externí odkaz: https://doaj.org/article/8a24e615d5e5485ab8b33125a28af988

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Akademický článek

Anti-cancer effects of REIC/Dkk-3-encoding adenoviral vector for the treatment of non-small cell lung cancer.

Autor: Kazuhiko Shien, Norimitsu Tanaka, Masami Watanabe, Junichi Soh, Masakiyo Sakaguchi, Keitaro Matsuo, Hiromasa Yamamoto, Masashi Furukawa, Hiroaki Asano, Kazunori Tsukuda, Yasutomo Nasu, Nam-Ho Huh, Shinichiro Miyoshi, Hiromi Kumon, Shinichi Toyooka

Publikováno v: PLoS ONE, Vol 9, Iss 2, p e87900 (2014)

REIC/Dkk-3 is down-regulated in a broad range of human cancer cells and is considered to function as a tumor suppressor. We previously reported that REIC/Dkk-3-expressing adenovirus vector (Ad-REIC) induced endoplasmic reticulum (ER) stress and cance

Externí odkaz: https://doaj.org/article/ac58e6e1567d4e58828818b1e6530d1b

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Akademický článek

TIRAP, an adaptor protein for TLR2/4, transduces a signal from RAGE phosphorylated upon ligand binding.

Autor: Masakiyo Sakaguchi, Hitoshi Murata, Ken-ichi Yamamoto, Tomoyuki Ono, Yoshihiko Sakaguchi, Akira Motoyama, Toshihiko Hibino, Ken Kataoka, Nam-ho Huh

Publikováno v: PLoS ONE, Vol 6, Iss 8, p e23132 (2011)

The receptor for advanced glycation end products (RAGE) is thought to be involved in the pathogenesis of a broad range of inflammatory, degenerative and hyperproliferative diseases. It binds to diverse ligands and activates multiple intracellular sig

Externí odkaz: https://doaj.org/article/88d0f8c7fad7462ea7c29c8019a449d2

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Akademický článek

Suppression of Carbon Tetrachloride-Induced Liver Fibrosis by Transplantation of a Clonal Mesenchymal Stem Cell Line Derived from Rat Bone Marrow

Autor: Marhaen Hardjo, Masahiro Miyazaki, Masakiyo Sakaguchi, Takuro Masaka, Sukaeni Ibrahim, Ken Kataoka, Nam-Ho Huh

Publikováno v: Cell Transplantation, Vol 18 (2009)

Transplantation of hepatocytes or bone marrow-derived cells has been shown to ameliorate liver fibrosis in animal models, but no direct comparison of relative efficiency has been made. The aim of this study was to compare the efficiency of a bone mar

Externí odkaz: https://doaj.org/article/0d0cd756dcf342dda995f1f1cabc1f63

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Akademický článek

Propagation of Adult Rat Bone Marrow-Derived Hepatocyte-Like Cells by Serial Passages in Vitro

Autor: Masahiro Miyazaki Ph.D., Takuro Masaka, Ichiro Akiyama, Emiko Nakashima, Masakiyo Sakaguchi, Nam-Ho Huh

Publikováno v: Cell Transplantation, Vol 13 (2004)

Previously, we found that hepatocyte growth factor receptor (c-Met)-and alpha-fetoprotein (AFP)-expressing cells were present in adult rat bone marrow, and that these cells also expressed hematopoietic stem cell markers, such as CD34, Thy-1, and c-Ki

Externí odkaz: https://doaj.org/article/14335dee69714ba392f92f8f79df6460

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