Zobrazeno 1 - 10
of 318
pro vyhledávání: '"Nam-Chul Ha"'
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
Many pathogenic bacteria form biofilms that are resistant to not only host immune defenses but also antibiotics, posing a need for the development of strategies to control biofilms. In this study, to prevent biofilm formation of the fulminating foodb
Externí odkaz:
https://doaj.org/article/dfe949f4c6fb46f198f2ab552e91d0d7
Autor:
Sojeong Heo, Seung-Eun Oh, Gawon Lee, Jinwook Lee, Nam-Chul Ha, Che Ok Jeon, Keuncheol Jeong, Jong-Hoon Lee, Do-Won Jeong
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract The foodborne bacterium Staphylococcus equorum strain KS1030 harbours plasmid pSELNU1, which encodes a lincomycin resistance gene. pSELNU1 undergoes horizontal transfer between bacterial strains, thus spreading antibiotic resistance. However
Externí odkaz:
https://doaj.org/article/9978a21e3fa749e2a20cc99816ae60b0
Autor:
Yeongjin Baek, Tae-Gyun Woo, Jinsook Ahn, Dukwon Lee, Yonghoon Kwon, Bum-Joon Park, Nam-Chul Ha
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
Characterization of the structure of an overoxidation-mimicking double mutant of superoxide dismutase SOD1 shows the production of more cytotoxic filaments seen in amyotrophic lateral sclerosis (ALS) neurons.
Externí odkaz:
https://doaj.org/article/9ce17dc2d1834164a9353fb288e966a8
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-8 (2022)
Increased hydrophobicity identified by the crystal structure presented in this work suggests a mechanism by which the S143F form of lamin A/C leads to progeria, a rapid aging syndrome. The authors observed aberrant molecular interactions that appear
Externí odkaz:
https://doaj.org/article/0720ca4774fc4f8f98266476fb503150
Autor:
Tae-Gyun Woo, Min-Ho Yoon, So-mi Kang, Soyoung Park, Jung-Hyun Cho, Young Jun Hwang, Jinsook Ahn, Hyewon Jang, Yun-Jeong Shin, Eui-Man Jung, Nam-Chul Ha, Bae-Hoon Kim, Yonghoon Kwon, Bum-Joon Park
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
With ELISA-based screening, Woo et al. identify a new small molecule, PRG-A01, which can block the misfolding/aggregation of SOD1 or TDP-43 in a human neuroblastoma cell line. Its use in a mouse model of ALS results in improvement of muscle strength,
Externí odkaz:
https://doaj.org/article/f1e4045faeb04055bfa9700b0679930b
Autor:
So-mi Kang, Min-Ho Yoon, Su-Jin Lee, Jinsook Ahn, Sang Ah Yi, Ki Hong Nam, Soyoung Park, Tae-Gyun Woo, Jung-Hyun Cho, Jaecheol Lee, Nam-Chul Ha, Bum-Joon Park
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Werner syndrome (WRN) is a rare progressive genetic disorder, caused by functional defects in WRN protein and RecQ4L DNA helicase. Acceleration of the aging process is initiated at puberty and the expected life span is approximately the late
Externí odkaz:
https://doaj.org/article/01b8eaca40fd400584abe15784946828
Autor:
So‑mi Kang, Min‑Ho Yoon, Su‑Jin Lee, Jinsook Ahn, Sang Ah Yi, Ki Hong Nam, Soyoung Park, Tae‑Gyun Woo, Jung‑Hyun Cho, Jaecheol Lee, Nam‑Chul Ha, Bum‑Joon Park
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-3 (2021)
Externí odkaz:
https://doaj.org/article/428ebffdc66f4231b713e0d9a95b58d2
Autor:
So-mi Kang, Min-Ho Yoon, Jinsook Ahn, Ji-Eun Kim, So Young Kim, Seock Yong Kang, Jeongmin Joo, Soyoung Park, Jung-Hyun Cho, Tae-Gyun Woo, Ah-Young Oh, Kyu Jin Chung, So Yon An, Tae Sung Hwang, Soo Yong Lee, Jeong-Su Kim, Nam-Chul Ha, Gyu-Yong Song, Bum-Joon Park
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Kang, Park and colleagues develop and demonstrate the effects of a new drug candidate for treatment of Hutchinson-Gilford progeria syndrome pathologies. Progerinin extends the life span of mice used to model this disease and induces histological and
Externí odkaz:
https://doaj.org/article/f096a2f1eb914af38e3c04e0baf1efeb
Publikováno v:
Journal of Functional Foods, Vol 87, Iss , Pp 104843- (2021)
Externí odkaz:
https://doaj.org/article/f29264788cdf42ecab493b91b6392ce3
Autor:
Jinsook Ahn, Inseong Jo, So-mi Kang, Seokho Hong, Suhyeon Kim, Soyeon Jeong, Yong-Hak Kim, Bum-Joon Park, Nam-Chul Ha
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Lamins are intermediate filaments and the major component of the nuclear lamina. Here the authors determine the crystal structure of a construct comprising the N-terminal half of human lamin A/C and use their structure and cross-linking and biochemic
Externí odkaz:
https://doaj.org/article/eaabcdf6ad91467b8115d9254282e1c7