Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Nam T. Le"'
Autor:
Christopher T. Smith, Linh C. Dang, Leah L. Burgess, David H. Zald, Darcy K. Smith, Ronald L. Cowan, Scott F. Perkins, Nam T. Le, Gregory R. Samanez-Larkin, Robert M. Kessler, M. Danica San Juan
Publikováno v:
Psychopharmacology. 236:581-590
RATIONALE: Sex differences in the dopaminergic response to psychostimulants could have implications for drug abuse risk and other psychopathology involving the dopamine system, but human data are limited and mixed. OBJECTIVES: Here, we sought to inve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1bfbb74f73142952077f89984c7167c
https://doi.org/10.1007/s00213-018-5083-5
https://doi.org/10.1007/s00213-018-5083-5
Autor:
David H. Zald, Ronald L. Cowan, Scott F. Perkins, Nam T. Le, Gregory R. Samanez-Larkin, Linh C. Dang, Jaime J. Castrellon
Publikováno v:
NeuroImage. 148:123-129
Physical activity has been shown to ameliorate dopaminergic degeneration in non-human animal models. However, the effects of regular physical activity on normal age-related changes in dopamine function in humans are unknown. Here we present cross-sec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14e9f738109e591ecc8202c6b4cc9d14
https://doi.org/10.1016/j.neuroimage.2017.01.018
https://doi.org/10.1016/j.neuroimage.2017.01.018
Autor:
Shaoqing Chen, Paul Gillespie, Sung-Sau So, Steven Gregory Mischke, David Robert Bolin, Nam T. Le, Frank Mennona, Mushtaq Ahmad, Karin Conde-Knape, Charles Burghardt, Hong Wang, Shahid Tannu, Yimin Qian, Jarema Peter Kochan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:6264-6269
Through high throughput screening and subsequent hit identification and optimization, we synthesized a series of 1-arylcarbonyl-6,7-dimethoxyisoquinoline derivatives as the first reported potent and reversible GFAT inhibitors. SAR studies of this cla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1ce41d6fc54e9d94c3232db8c5a857f
https://doi.org/10.1016/j.bmcl.2011.09.009
https://doi.org/10.1016/j.bmcl.2011.09.009
Autor:
Jin-Jun Liu, Christophe Michoud, Feng Chi, Yang Wen, Qing Xiang, Nam T. Le, Shaoqing Chen, Nicole Jackson, Jian Ping Lou, Li Chen, Chunlin Zhao, Achyutharao Sidduri, Louis Portland, Lyubomir T. Vassilev, Fred Konzelmann, Yingsi Chen, Christian Tovar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:2134-2138
A novel series of quinolinyl-methylene-thiazolinones has been identified as potent and selective cyclin-dependent kinase 1 (CDK1) inhibitors. Their synthesis and structure activity relationships (SAR) are described. Representative compounds from this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fab9e1e7142c358c44595074f3b33ef8
https://doi.org/10.1016/j.bmcl.2007.01.081
https://doi.org/10.1016/j.bmcl.2007.01.081
Autor:
Cheryl Janson, Martin Weisel, Barry Goggin, Liang Weiling, Adrian J. Fretland, Robert Francis Kester, Christine Lukacs, Edmund Lee, Jennifer Lo, J. Heather Hogg, Xiaochun Han, Kyoungja Hong, Stacy Remiszewski, Shirley Li, Ann Polonskaia, John Anthony Moliterni, Kang Le, Lin Gao, Nam T. Le, Christophe Michoud, A. Schutt, Shahid Tannu, Andrew F. Donnell, Shaoqing Chen, Louis J. Lombardo, Steven Gregory Mischke, Mark T. Dvorozniak, Yan Lou, Christine Tardell, Kenneth Carey Rupert, Doug Aguilar, Dave S. Solis
Publikováno v:
Journal of medicinal chemistry. 56(20)
The IAPs are key regulators of the apoptotic pathways and are commonly overexpressed in many cancer cells. IAPs contain one to three BIR domains that are crucial for their inhibitory function. The pro-survival properties of XIAP come from binding of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54996c22c1d8fb8749b427ec42349aeb
https://pubmed.ncbi.nlm.nih.gov/24093940
https://pubmed.ncbi.nlm.nih.gov/24093940
Autor:
Hoffmeister, Darius1,2 (AUTHOR) d.hoffmeister@fz-juelich.de, Finger, Selina1,2 (AUTHOR) s.finger@fz-juelich.de, Fiedler, Lena1,2 (AUTHOR), Ma, Tien‐Ching1,2 (AUTHOR), Körner, Andreas1 (AUTHOR), Zlatar, Matej1,2 (AUTHOR), Fritsch, Birk1 (AUTHOR), Bodnar, Kerstin Witte3,4 (AUTHOR), Carl, Simon5 (AUTHOR), Götz, Alexander5 (AUTHOR), Zubiri, Benjamin Apeleo5 (AUTHOR), Will, Johannes5 (AUTHOR), Spiecker, Erdmann5 (AUTHOR), Cherevko, Serhiy1 (AUTHOR), Freiberg, Anna T. S.1,2 (AUTHOR), Mayrhofer, Karl J. J.1,2 (AUTHOR), Thiele, Simon1,2 (AUTHOR), Hutzler, Andreas1 (AUTHOR) a.hutzler@fz-juelich.de, van Pham, Chuyen1 (AUTHOR) c.pham@fz-juelich.de
Publikováno v:
Advanced Science. 8/14/2024, Vol. 11 Issue 30, p1-15. 15p.
Autor:
Nam T. Le, Kang Le, Zhi Chen, Yingsi Chen, Tom Nevins, Shaoqing Chen, Steve Mischke, David Joseph Bartkovitz, Jianping Cai, Goli Naderi-Oboodi, Weiguo Qing, Xin-Jie Chu, John Frederick Boylan, Kin Chun Luk, Yi Chen, Peter Michael Wovkulich
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(2)
A series of pyrimidodiazepines was identified as potent Polo-like kinase 1 (PLK1) inhibitors. The synthesis and SAR are discussed. The lead compound 7 (RO3280) has potent inhibitory activity against PLK1, good selectivity against other kinases, and e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edcb14437e7b95274bb866375731eb92
https://pubmed.ncbi.nlm.nih.gov/22172702
https://pubmed.ncbi.nlm.nih.gov/22172702
Autor:
Smith, Christopher T.1 christopher.t.smith@vanderbilt.edu, Dang, Linh C.1, Burgess, Leah L.1, Perkins, Scott F.1, San Juan, M. Danica1, Smith, Darcy K.1, Cowan, Ronald L.1,2,3, Le, Nam T.3, Kessler, Robert M.4, Samanez-Larkin, Gregory R.5, Zald, David H.1,2
Publikováno v:
Psychopharmacology. Feb2019, Vol. 236 Issue 2, p581-590. 10p. 2 Charts, 1 Graph.
Autor:
Meteling, Henning J., Bosse, Florian, Schlichter, Lisa, Tyler, Bonnie J., Arlinghaus, Heinrich F., Ravoo, Bart Jan
Publikováno v:
Small; Sep2022, Vol. 18 Issue 37, p1-7, 7p
Publikováno v:
Journal of Planning Literature; Aug2021, Vol. 36 Issue 3, p283-296, 14p