Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Nam Sook Kang"'
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 4683-4696 (2023)
Fragment-based drug discovery (FBDD) is a well-established and effective method for generating diverse and novel hits in drug design. Kinases are suitable targets for FBDD due to their well-defined structure. Water molecules contribute to structure a
Externí odkaz:
https://doaj.org/article/dbec0ba4ba10433aacddf2d048c46fd7
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 425-431 (2023)
Several diverse proteins possess similar binding sites. Protein binding site comparison provides valuable insights for the drug discovery and development. Binding site similarities are useful in understanding polypharmacology, identifying potential o
Externí odkaz:
https://doaj.org/article/7b1ad06eed014fc9901d8ebb9eb441ae
Autor:
Anand Balupuri, Jeong-Min Kim, Kwang-Eun Choi, Jin Sun No, Il-Hwan Kim, Jee Eun Rhee, Eun-Jin Kim, Nam Sook Kang
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 22, p 16069 (2023)
The continuous emergence of new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with multiple spike (S) protein mutations pose serious threats to current coronavirus disease 2019 (COVID-19) therapies. A comprehensive understandi
Externí odkaz:
https://doaj.org/article/fe0c97fdd70c43e1bc7cbc9dd4b1a3b5
Autor:
Susoma Jannat, Anand Balupuri, Md Yousof Ali, Seong Su Hong, Chun Whan Choi, Yun-Hyeok Choi, Jin-Mo Ku, Woo Jung Kim, Jae Yoon Leem, Ju Eun Kim, Abinash Chandra Shrestha, Ha Neul Ham, Kee-Ho Lee, Dong Min Kim, Nam Sook Kang, Gil Hong Park
Publikováno v:
Experimental and Molecular Medicine, Vol 51, Iss 2, Pp 1-18 (2019)
Alzheimer’s disease: Promising therapeutic compounds found in plants Compounds extracted from bracken fern block the activity of three enzymes associated with Alzheimer’s disease (AD). Because AD is a complex and multifactorial disease, a multita
Externí odkaz:
https://doaj.org/article/5ae3be2dc39f46c2984bc757d6b01c33
Autor:
Eun-Sil Lee, Nayeon Kim, Joon Hee Kang, Aizhan Abdildinova, Seon-Hyeong Lee, Myung Hwi Lee, Nam Sook Kang, Tae-Sung Koo, Soo-Youl Kim, Young-Dae Gong
Publikováno v:
Pharmaceuticals, Vol 15, Iss 5, p 502 (2022)
Cancer cells are characterized by an abnormal cell cycle. Therefore, the cell cycle has been a potential target for cancer therapeutic agents. We developed a new lead compound, DGG200064 (7c) with a 2-alkoxythieno [2,3-b]pyrazine-3-yl)-4-arylpiperazi
Externí odkaz:
https://doaj.org/article/75395455dedd40b3a5465361f2b54b5f
Autor:
Kwang-Eun Choi, Jeong-Min Kim, Jee Eun Rhee, Ae Kyung Park, Eun-Jin Kim, Cheon Kwon Yoo, Nam Sook Kang
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 9, p 4956 (2022)
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has caused the Coronavirus Disease (COVID-19) pandemic worldwide. The spike protein in SARS-CoV-2 fuses with and invades cells in the host respiratory system by binding to angiotensin-conve
Externí odkaz:
https://doaj.org/article/6457066d658441b8b65d4831d39ec3c1
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 6, p 3337 (2022)
The intrinsic inductive properties of atoms or functional groups depend on the chemical properties of either electron-withdrawing groups (EWGs) or electron-donating groups (EDGs). This study aimed to evaluate in silico methods to determine whether ch
Externí odkaz:
https://doaj.org/article/bb5e7212817a4a7d9f7d52dabc0908e9
Autor:
Myung-Gyun Kang, Nam Sook Kang
Publikováno v:
Molecules, Vol 26, Iss 24, p 7548 (2021)
Drug-induced liver injury (DILI) is a major concern for drug developers, regulators, and clinicians. However, there is no adequate model system to assess drug-associated DILI risk in humans. In the big data era, computational models are expected to p
Externí odkaz:
https://doaj.org/article/7507ba129a834b74b9dff93e98decc63
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 16, p 8714 (2021)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) affects the COVID-19 pandemic in the world. The spike protein of the various proteins encoded in SARS-CoV-2 binds to human ACE2, fuses, and enters human cells in the respiratory system. Spi
Externí odkaz:
https://doaj.org/article/4162d87b2b614172a64b280ce5b69519
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 18, p 6826 (2020)
Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is a protein kinase with diverse functions in cell regulation. Abnormal expression and activity of DYRK1A contribute to numerous human malignancies, Down syndrome, and Alzheimer
Externí odkaz:
https://doaj.org/article/2367637edb6f4bd99898cdf8c896ef47