Evaluation of the systemic and spinal antinociceptive effect of a new hybrid NSAID tetrahydropyran derivative

Autor: Roberto Laureano-Melo, Vivian de Assunção Nogueira Carvalho, Gabriela Mastrangelo Gonçalves, Thayane Ferreira da Costa Fernandes, Bruno Guimarães Marinho, Saulo Luis Capim, Joyce Mattos de Oliveira, Mário L. A. A. Vasconcellos, Gabriela de Carvalho Cid, Wellington da Silva Côrtes

Publikováno v: Clinical and Experimental Pharmacology and Physiology. 49:419-431

Pain is responsible for inducing physical and mental stress, interfering negatively in patients' quality of life. Classic analgesic drugs, such as opioids and non-steroidal anti-inflammatory drugs, are known for their wide range of adverse effects, m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26a2fa619cb373b3f15d1ee587275d05
https://doi.org/10.1111/1440-1681.13617

Hair Growth Promotion by δ-Opioid Receptor Activation

Autor: Gianfranco Balboni, Mei Zheng, Jong-Hyuk Sung, Ying Xia, Nahyun Choi

Publikováno v: Biomolecules & Therapeutics

Literature has revealed that the delta opioid receptor (DOR) exhibited diverse pharmacological effects on neuron and skin. In the present study, we have investigated whether the activation of DOR has hair-growth promotion effects. Compared with other

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b374a574aa4953e9b9ab2037cc420950
https://doi.org/10.4062/biomolther.2021.064

Antagonism of the mu-delta opioid receptor heterodimer enhances opioid antinociception by activating Src and calcium/calmodulin-dependent protein kinase II signaling

Autor: Natalie K. Barker, John M. Streicher, Attila Keresztes, Ryan Hecksel, Keith M. Olson, Marissa A. Lopez-Pier, Paul R. Langlais, Victor J. Hruby, John P. Konhilas, Paul L. Nguyen, Zekun Liu

Publikováno v: Pain. 163:146-158

The opioid receptors are important regulators of pain, reward, and addiction. Limited evidence suggests the mu and delta opioid receptors form a heterodimer (MDOR), which may act as a negative feedback brake on opioid-induced analgesia. However, evid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::260154a616c22268260bc514dfc074fe
https://doi.org/10.1097/j.pain.0000000000002320

Pharmacokinetic neuroimaging to study the dose-related brain kinetics and target engagement of buprenorphine in vivo

Autor: Matteo Tonietto, Catriona Wimberley, Sébastien Goutal, Sylvain Auvity, Dominique Vodovar, Fabien Caillé, Alain Pruvost, Nicolas Tournier, Michel Bottlaender, Claire Leroy

Publikováno v: Neuropsychopharmacology
Neuropsychopharmacology, Nature Publishing Group, 2021, 46 (6), pp.1220-1228. ⟨10.1038/s41386-021-00976-w⟩
Neuropsychopharmacology, 2021, 46 (6), pp.1220-1228. ⟨10.1038/s41386-021-00976-w⟩

International audience; A wide range of buprenorphine doses are used for either pain management or maintenance therapy in opioid addiction. The complex in vitro profile of buprenorphine, with affinity for µ-, δ-, and κ-opioid receptors (OR), makes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44af665c9a72e037029bbdafa835f1cb
https://doi.org/10.1038/s41386-021-00976-w

The Opioid Interactions of the Antipsychotic Medications Risperidone and Amisulpride in Mice and Their Potential Use in the Treatment of Other Non-Psychotic Medical Conditions

Autor: Chaim G. Pick, Shaul Schreiber

Publikováno v: Cellular and Molecular Neurobiology. 41:1077-1084

Pain is defined as an unpleasant sensory and emotional experience associated with actual or potential tissue damage. The opioid epidemic in the USA has highlighted the need for alternative treatments for pain. Following reports on the opioid interact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e4904424f98f671a0f22dc4d33e3e36
https://doi.org/10.1007/s10571-020-01001-2