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Akademický článek

Synthetic opioids have disrupted conventional wisdom for treating opioid overdose

Autor: Phil Skolnick, Jordan Paavola, Christian Heidbreder

Publikováno v: Drug and Alcohol Dependence Reports, Vol 12, Iss , Pp 100268- (2024)

More than 90 % of opioid overdose deaths in North America are now caused by synthetic opioids, and while they are not as prevalent in the European illicit drug market, there are indications that they may become so in the near future. Multiple publica

Externí odkaz: https://doaj.org/article/3d50414000db4096bef8096a6b5f4e62

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Akademický článek

Effect of Preadministration of Nalmefene on Sufentanil-Induced Cough During Induction of General Anesthesia in Patients Undergoing Breast Surgery: A Double-Blind Randomized Controlled Trial

Autor: Xie W, He H, Hong J, Feng C, Li W, Li Y

Publikováno v: Drug Design, Development and Therapy, Vol Volume 18, Pp 1865-1874 (2024)

Weiji Xie,1,* Honglian He,2,* Jishuang Hong,3 Chengfei Feng,1 Wei Li,1 Yongchun Li1 1Department of Anesthesiology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen Universi

Externí odkaz: https://doaj.org/article/730cb78a188e44438b4c8efcdb830d5f

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Akademický článek

Editorial: Discovery, development and implementation of improved options for treating opioid overdose in the synthetic opioid era

Autor: Christian Heidbreder, Mark K. Greenwald, Bernard Le Foll, Phil Skolnick

Publikováno v: Frontiers in Psychiatry, Vol 15 (2024)

Externí odkaz: https://doaj.org/article/59eea10dcce247c18da0527ca550e9e0

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Akademický článek

Nalmefene, an opioid receptor modulator, aggravates atherosclerotic plaque formation in apolipoprotein E knockout mice by enhancing oxidized low-density lipoprotein uptake in macrophages

Autor: Mitsuhisa Koga, Koshun Inada, Ayano Yamada, Kana Maruoka, Atsushi Yamauchi

Publikováno v: Biochemistry and Biophysics Reports, Vol 38, Iss , Pp 101688- (2024)

Nalmefene, an antagonist of mu- and delta-opioid receptors and a partial agonist of kappa-opioid receptors, has shown promise in reducing alcohol consumption among patients with alcohol dependence. Opioid receptors play pivotal roles in various physi

Externí odkaz: https://doaj.org/article/a8c287eb789b4a3a827c4054fb21d38b

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Akademický článek

Different doses of nalmefene combined with hydromorphone hydrochloride for postoperative analgesia after colorectal surgery: a randomized controlled study

Autor: Ye Wang, Lin Zhao, Meng Wu, Qi An, Qianqian Guo, Chunling Fan, Zhenggang Guo

Publikováno v: BMC Surgery, Vol 24, Iss 1, Pp 1-9 (2024)

Abstract Background Hydromorphone hydrochloride has a satisfactory postoperative analgesic effect for patients with colorectal cancer but is accompanied by a relatively high incidence of adverse events. Low-doses of naloxone combined with opioids for

Externí odkaz: https://doaj.org/article/02dbcc8f768642278af3c50ce6b9555e

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Akademický článek

The efficacy of nalmefene on anesthetic recovery of patients: a study protocol for a multicenter randomized controlled trial

Autor: Xiaowen Ma, Jueying Liu, Ying Tang, Qiueyue Lian, Xiaorong Huai, Wanfeng Liu, Diansan Su

Publikováno v: Trials, Vol 24, Iss 1, Pp 1-10 (2023)

Abstract Introduction So far, the recovery quality after general anesthesia is still unsatisfied. Nalmefene is a drug to treat opioid overdose and reverse opioid actions. We aim to investigate the efficacy of nalmefene on optimizing the recovery qual

Externí odkaz: https://doaj.org/article/f54b843946344dba8541632d1b186203

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Akademický článek

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Akademický článek

Sufentanil combined with nalmefene reduce the adverse events in recovery period of patients undergoing uvulopalatopharyngoplasty – A randomized controlled trial

Autor: Jin Wang, Kang Zheng, Quan Wen, Jie Sun

Publikováno v: Heliyon, Vol 9, Iss 2, Pp e13241- (2023)

Background: The opioid receptors related to analgesia are mainly μ recipient, the μ receptor has a two-way mode of action: manifested by opioid analgesics and μ1 Receptor binding produces the desired analgesic effect, and μ2 Receptor binding may

Externí odkaz: https://doaj.org/article/43a1acae2e8846649fdfcafb9bd63fb4

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Akademický článek

Nalmefene vs. dexmedetomidine for prevention of postoperative hyperalgesia in patients undergoing laparoscopic gynecological surgery with remifentanil infusion: A randomized double-blind controlled trial

Autor: Zhen Jia, Yi Chen, Tianyu Gao, Yuan Yuan, Yuxin Zheng, Yegong Xie, Guolin Wang, Yonghao Yu, Linlin Zhang

Publikováno v: Frontiers in Pharmacology, Vol 14 (2023)

Intraoperative remifentanil infusion may paradoxically induce post-surgical hyperalgesia. Dexmedetomidine reportedly reduces opioid-induced hyperalgesia. Nalmefene selectively reverses several side-effects of opioids without impairing analgesia. Here

Externí odkaz: https://doaj.org/article/2981aed870c743a198011c92028055b7

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