A 3′-UTR KRAS-variant is associated with cisplatin resistance in patients with recurrent and/or metastatic head and neck squamous cell carcinoma

Autor: Chung, C.H. ^*, Lee, J.W., Slebos, R.J., Howard, J.D., Perez, J., Kang, H., Fertig, E.J., Considine, M., Gilbert, J., Murphy, B.A., Nallur, S., Paranjape, T., Jordan, R.C., Garcia, J., Burtness, B., Forastiere, A.A., Weidhaas, J.B.

Publikováno v: In Annals of Oncology November 2014 25(11):2230-2236

S02. The Next Step in Cardiac Genetics: Targeted gene panels and next generation sequencing in inherited cardiac conditions

Autor: Deeny, HA, Murphy, AM, O'Rourke, D, Gallagher, S, Rea, G, Ware, JS, Lightman, EG, Walsh, R, John, S, Homfray, T, Till, J, Prasad, S, Buchan, R, Wilkinson, S, Barton, PJR, Cook, SA, McVeigh, TP, Cody, N, Meany, M, Carroll, C, O'Shea, R, Gallagher, DJ, Clabby, C, Green, AJ, Casey, J, Crushell, E, Hughes, J, Losty, E, Slattery, D, Green, A, Ennis, S, Lynch, SA, Kirk, CW, McKee, S, Project, DDD, Al Shehhi, M, Shen, S, Gallagher, L, Betts, DR, McArdle, L, Quinn, EM, Coleman, C, Molloy, B, Dominguez Castro, P, Trimble, V, Mahmud, N, McManus, R, Jung, S, Salzman, D, Kerin, MJ, Nallur, S, Dookwah, M, Nemec, AA, Sadofsky, J, Paranjape, T, Kelly, O, Chan, E., Miller, N, Sweeney, KJ, Zelterman, D, Sweasy, J, Pilarski, R, Telesca, D, Weidhaas, JB, Stapleton, CP, McCormack, M, Connaughton, D, Phelan, PJ, Cavalleri, GL, Conlon, PJ, Gilbert, E, O'Reilly, S, Merrigan, M, McGettigan, D, Cavalleri, G, Heavin, SB, Slattery, L, Walley, N, Avbersek, A, Novy, J, Sinha, S, Alarts, N, Legros, B, Radtke, R, Doherty, C, Depondt, C, Sisodiya, S, Goldstein, D, Delanty, N, Nesbit, MA, Courtney, DG, Allen, EHA, Atkinson, SD, Maurizi, E, Moore, JE, Pedrioli, DM Leslie, McLean, WHI, Moore, CBT, Petyrka, J, Vieira, M, Donnelly, DE, O'Neill, T, Hardy, R, Morrison, PJ, Hegarty, M, Irvine, M, Dabir, T, Zhang, X, Dineen, T, Flanagan, J, Kovacs, A, Mihart, R, O'Callaghan, J, Culligan, J, Daly, N, McAuliffe, D, Waterstone, J, Owens, P, Guerin, C, Quill, D, Bell, M, Lowery, AJ, Bradley, L, Barton, DE, Matthews, J, Turner, J, O'Byrne, JJ, Fitzsimons, PE, Unger, S, Croft, J, Mayne, PD, Moylette, E, McDonnell, C, Parker, VE, Al-Shehhi, M, Kelly, PM, Costigan, C, Hegarty, A, Knox, R, Byrne, S, Semple, LRK., Irvine, A, McDaid, J, Ryan, H, Dunne, A, Lambert, DM, Treacy, EP, Lynch, SM, McKenna, MM, Walsh, CP, McKenna, DJ, Whitton, L, Cosgrove, D, Clarkson, C, Gill, M, Corvin, A, Rea, S, Donohoe, G, Morris, D, Neville, J, Ryan, AM, Hand, CK, Ryan, E, Ryan, F, Barton, D, O'Dwyer, V, Neylan, D, Nesbitt, H, Byrne, NM, Worthington, J, Mc Keown, SR, Mc Kenna, DJ, Harold, D, Holland, J, Mothershill, O, Allen, EH, Leslie Pedrioli, DM, Courtney, D, Cole, A, Cox, S, Jeong, C, Droma, Y, Hanaoka, M, Ota, M, Gasparini, P, Montgomery, H, Di Rienzo, A, Robbins, P, L. Cavalleri, G, Heavin, S, Buckley, P, Irwin, RE, Thakur, A, O’ Neill, KM, Cummins, Paul, Mackin, SJ, O'Neill, K, Walsh, C, Schiroli, D, Mulligan, R, Sebag, F, Ozaki, M, Molloy, AM, Mills, JL, Fan, R, Wang, Y, Gibney, ER, Shane, B, Brody, LC, Parle-Mcdermott, A, O'Halloran, ET, Ebrahim, A, Meydan, C, Mason, C, Magalhães, TR

Publikováno v: The Ulster Medical Journal

Aims The Irish DNA Atlas is a DNA collection being assembled with the aim of describing the fine-scale population structure in Ireland. Understanding such structure can inform on optimal design of clinical genetic studies as well as the history of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmc_________::8954599fc3cb5de9d5f4819409a3d6a4
http://europepmc.org/articles/PMC4642251

miR-34 activity is modulated through 5 '-end phosphorylation in response to DNA damage

Autor: Salzman, DW, Nakamura, K, Nallur, S, Dookwah, MT, Metheetrairut, C, Slack, FJ, Weidhaas, JB

Publikováno v: Salzman, DW; Nakamura, K; Nallur, S; Dookwah, MT; Metheetrairut, C; Slack, FJ; et al.(2016). miR-34 activity is modulated through 5 '-end phosphorylation in response to DNA damage. NATURE COMMUNICATIONS, 7, 10954. doi: 10.1038/ncomms10954. UCLA: Retrieved from: http://www.escholarship.org/uc/item/7d48d0np

MicroRNA (miRNA) expression is tightly regulated by several mechanisms, including transcription and cleavage of the miRNA precursor RNAs, to generate a mature miRNA, which is thought to be directly correlated with activity. MiR-34 is a tumour-suppres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::18b03ad18da8826599c3a1b078973ad6
http://www.escholarship.org/uc/item/7d48d0np

Targeted resequencing of the microRNAome and 3′UTRome reveals functional germline DNA variants with altered prevalence in epithelial ovarian cancer

Autor: Chen, X, Paranjape, T, Stahlhut, C, McVeigh, T, Keane, F, Nallur, S, Miller, N, Kerin, M, Deng, Y, Yao, X, Zhao, H, Weidhaas, JB, Slack, FJ

Publikováno v: Chen, X; Chen, X; Paranjape, T; Stahlhut, C; McVeigh, T; Keane, F; et al.(2014). Targeted resequencing of the microRNAome and 3′UTRome reveals functional germline DNA variants with altered prevalence in epithelial ovarian cancer. Oncogene. doi: 10.1038/onc.2014.117. UCLA: Retrieved from: http://www.escholarship.org/uc/item/7zf6843m

Ovarian cancer is a major cause of cancer deaths, yet there have been few known genetic risk factors identified, the best known of which are disruptions in protein coding sequences (BRCA1 and 2). Recent findings indicate that there are powerful genet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::e58e52ee3bd2b5a2d3997e2e4e6ea403
http://www.escholarship.org/uc/item/7zf6843m

cel-mir-237and its homologue, hsa-miR-125b, modulate the cellular response to ionizing radiation

Autor: Metheetrairut, C, Adams, B D, Nallur, S, Weidhaas, J B, Slack, F J

Publikováno v: Oncogene; January 2017, Vol. 36 Issue: 4 p512-524, 13p