Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Nallathamby, Devasahayam"'
Autor:
Tomohiro Seki, Yu Saida, Shun Kishimoto, Jisook Lee, Yasunori Otowa, Kazutoshi Yamamoto, Gadisetti VR Chandramouli, Nallathamby Devasahayam, James B. Mitchell, Murali C. Krishna, Jeffery R. Brender
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 30, Iss , Pp 100793- (2022)
Purpose: PEGylated human hyaluronidase (PEGPH20) enzymatically depletes hyaluronan, an important component of the extracellular matrix, increasing the delivery of therapeutic molecules. Combinations of chemotherapy and PEGPH20, however, have been uns
Externí odkaz:
https://doaj.org/article/f1585e36c7944ba19758e09803a3851d
Autor:
Yasunori Otowa, Shun Kishimoto, Yu Saida, Kota Yamashita, Kazutoshi Yamamoto, Gadisetti VR Chandramouli, Nallathamby Devasahayam, James B. Mitchell, Murali C. Krishna, Jeffery R. Brender
Publikováno v:
Antioxidants & Redox Signaling.
AimsPancreatic ductal adenocarcinomas (PDACs) form hypovascular and hypoxic tumors which are difficult to treat with current chemotherapy regimens. Gemcitabine (GEM) is often used as a first line treatment for PDACs, but has issues with chemoresistan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::069ab1e34afc6f99d3b3cbd141c156bf
https://doi.org/10.1089/ars.2022.0118
https://doi.org/10.1089/ars.2022.0118
Autor:
Shun Kishimoto, Nallathamby Devasahayam, Gadisetti VR Chandramouli, Ramachandran Murugesan, Yasunori Otowa, Kota Yamashita, Kazutoshi Yamamoto, Jeffrey R Brender, Murali C Krishna
PurposeIn this study, we compared two triarylmethyl (TAM) spin probes, Ox071 and Ox063 for their efficacy in measuring tissue oxygen concentration by R2*-based oximetry in hypoxic and normoxic conditions.MethodsThe R2* dependence with spin probe and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63c5c5c19a1efd9d1fbd86a753b91b61
https://doi.org/10.1101/2023.05.18.541366
https://doi.org/10.1101/2023.05.18.541366
Autor:
Murali C. Krishna, James B. Mitchell, Robert J. Gillies, Charles P. Hart, Nallathamby Devasahayam, Jeeva P. Munasinghe, Yoichi Takakusagi, Keita Saito, Shun Kishimoto, Shingo Matsumoto
Clonogenic assay for Hs766t cells treated with gemcitabine 100 nM in ambient air and anoxic condition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f672f934e4d042ed04da415f93843d
https://doi.org/10.1158/0008-5472.22420328
https://doi.org/10.1158/0008-5472.22420328
Autor:
Murali C. Krishna, James B. Mitchell, Peter L. Choyke, Nallathamby Devasahayam, Keita Saito, Elaine M. Jagoda, Stephen S. Adler, Rajani Choudhuri, Nobu Oshima, Shun Kishimoto, Tomohiro Seki, Jeffrey R. Brender, Kazutoshi Yamamoto
Molecular imaging approaches for metabolic and physiologic imaging of tumors have become important for treatment planning and response monitoring. However, the relationship between the physiologic and metabolic aspects of tumors is not fully understo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb3236e0d2875d5e1a344f2344ad69b8
https://doi.org/10.1158/0008-5472.c.6511479.v1
https://doi.org/10.1158/0008-5472.c.6511479.v1
Autor:
Murali C. Krishna, James B. Mitchell, Robert J. Gillies, Charles P. Hart, Nallathamby Devasahayam, Jeeva P. Munasinghe, Yoichi Takakusagi, Keita Saito, Shun Kishimoto, Shingo Matsumoto
Median pO2 and HF10 of individual PDAC tumors in EPR oxygen imaging study.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a29f851c8f110d09b258df220f8217aa
https://doi.org/10.1158/0008-5472.22420325
https://doi.org/10.1158/0008-5472.22420325
Autor:
Murali C. Krishna, James B. Mitchell, Peter L. Choyke, Nallathamby Devasahayam, Keita Saito, Elaine M. Jagoda, Stephen S. Adler, Rajani Choudhuri, Nobu Oshima, Shun Kishimoto, Tomohiro Seki, Jeffrey R. Brender, Kazutoshi Yamamoto
Complete and detailed descriptions of materials and methods are in the supplementary information, including animal studies, image registration, hyperpolarized 13C MRI, 18F-FDG PET, EPR imaging, Western blot, Immunohistochemistry, and statistical anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a573026218dbb4c2a12e89b46e32e5a
https://doi.org/10.1158/0008-5472.22423344.v1
https://doi.org/10.1158/0008-5472.22423344.v1
Autor:
Murali C. Krishna, James B. Mitchell, Robert J. Gillies, Charles P. Hart, Nallathamby Devasahayam, Jeeva P. Munasinghe, Yoichi Takakusagi, Keita Saito, Shun Kishimoto, Shingo Matsumoto
Pancreatic ductal adenocarcinoma (PDAC) is characterized by hypoxic niches that lead to treatment resistance. Therefore, studies of tumor oxygenation and metabolic profiling should contribute to improved treatment strategies. Here, we define two imag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59fd427ac16ea1658e18a01116f950b1
https://doi.org/10.1158/0008-5472.c.6510623
https://doi.org/10.1158/0008-5472.c.6510623
Autor:
Murali C. Krishna, James B. Mitchell, Sankaran Subramanian, Keita Saito, Rajani Choudhuri, Jeeva P. Munasinghe, Nallathamby Devasahayam, Shingo Matsumoto, Hironobu Yasui
Supplementary Movie 2 from Low-Field Magnetic Resonance Imaging to Visualize Chronic and Cycling Hypoxia in Tumor-Bearing Mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30c623cf2392f8cb52dd0b9c80081fb4
https://doi.org/10.1158/0008-5472.22382579.v1
https://doi.org/10.1158/0008-5472.22382579.v1
Autor:
Murali C. Krishna, James B. Mitchell, Sankaran Subramanian, Keita Saito, Rajani Choudhuri, Jeeva P. Munasinghe, Nallathamby Devasahayam, Shingo Matsumoto, Hironobu Yasui
Supplementary Figure 1 from Low-Field Magnetic Resonance Imaging to Visualize Chronic and Cycling Hypoxia in Tumor-Bearing Mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9330872c4480bc90f59bf8d96d44a48
https://doi.org/10.1158/0008-5472.22382585.v1
https://doi.org/10.1158/0008-5472.22382585.v1