Výsledky vyhledávání - "Nalin Kataria"

Akademický článek

C-Terminal HSP90 Inhibitors Block the HIF-1 Hypoxic Response by Degrading HIF-1α through the Oxygen-Dependent Degradation Pathway

Autor: Nalin Kataria, Chloe-Anne Martinez, Bernadette Kerr, Samantha S. Zaiter, Monica Morgan, Shelli R. McAlpine, Kristina M. Cook

Publikováno v: Cellular Physiology and Biochemistry, Vol 53, Iss 3, Pp 480-495 (2019)

Externí odkaz: https://doaj.org/article/08cc13b86d8f465b8d621a35672ff588

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C-Terminal HSP90 Inhibitors Block the HIF-1 Hypoxic Response by Degrading HIF-1α through the Oxygen-Dependent Degradation Pathway

Autor: Samantha S. Zaiter, Nalin Kataria, Bernadette Kerr, Monica N Morgan, Shelli R. McAlpine, Chloe-Anne Martinez, Kristina M. Cook

Publikováno v: Cellular Physiology and Biochemistry, Vol 53, Iss 3, Pp 480-495 (2019)

Background/aims Hypoxia Inducible Factor-1α (HIF-1α) is involved in cancer progression and is stabilized by the chaperone HSP90 (Heat Shock Protein 90), preventing degradation. Previously identified HSP90 inhibitors bind to the N-terminal pocket of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bb9fc6aa72d8187904ae633e604ec52
https://www.cellphysiolbiochem.com/Articles/000152/

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