Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Nalin C. W. Goonesekere"'
Publikováno v:
Pharmaceuticals, Vol 14, Iss 3, p 209 (2021)
The high mortality rate for pancreatic cancer (PC) is due to the lack of specific symptoms at early tumor stages and a high biological aggressiveness. Reliable biomarkers and new therapeutic targets would help to improve outlook in PC. In this study,
Externí odkaz:
https://doaj.org/article/ee24363897204b5fa3c0f54d0acf71aa
Autor:
David P. Alt, Steven C. Olsen, Nalin C. W. Goonesekere, Betsy J. Bricker, Catherine E. Vrentas, Darrell O. Bayles
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 4, Pp 1175-1181 (2020)
G3: Genes|Genomes|Genetics
G3: Genes|Genomes|Genetics
The RB51 vaccine strain of Brucella abortus, which confers safe and effective protection of cattle from B. abortus infection, was originally generated via serial passage of B. abortus 2308 to generate spontaneous, attenuating mutations. While some of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e3bf08ced71abffcb646907df3c56e0
https://doi.org/10.1534/g3.119.400964
https://doi.org/10.1534/g3.119.400964
A meta analysis of pancreatic microarray datasets yields new targets as cancer genes and biomarkers.
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93046 (2014)
The lack of specific symptoms at early tumor stages, together with a high biological aggressiveness of the tumor contribute to the high mortality rate for pancreatic cancer (PC), which has a five year survival rate of less than 5%. Improved screening
Externí odkaz:
https://doaj.org/article/07571a614d9a466895cebe5ac75e02fb
Publikováno v:
Pharmaceuticals
Pharmaceuticals, Vol 14, Iss 209, p 209 (2021)
Pharmaceuticals, Vol 14, Iss 209, p 209 (2021)
The high mortality rate for pancreatic cancer (PC) is due to the lack of specific symptoms at early tumor stages and a high biological aggressiveness. Reliable biomarkers and new therapeutic targets would help to improve outlook in PC. In this study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b16113e7d1029ab965abe9fd20046a73
https://pubmed.ncbi.nlm.nih.gov/33802396
https://pubmed.ncbi.nlm.nih.gov/33802396
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 144:309-320
The lack of specific symptoms at early tumor stages, together with a high biological aggressiveness of the tumor contribute to the high mortality rate for pancreatic cancer (PC), which has a 5-year survival rate of about 7%. Recent failures of target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95d125e028c76d0b73e9efa6651af12d
https://doi.org/10.1007/s00432-017-2558-4
https://doi.org/10.1007/s00432-017-2558-4
Publikováno v:
British Journal of Medicine and Medical Research. 18:1-8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b8d23fad34d6830a54c7547b8432c73
https://doi.org/10.9734/bjmmr/2016/28034
https://doi.org/10.9734/bjmmr/2016/28034
Context-specific amino acid substitution matrices and their use in the detection of protein homologs
Autor:
Nalin C. W. Goonesekere, Byungkook Lee
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 71:910-919
The sequence homology detection relies on score matrices, which reflect the frequency of amino acid substitutions observed in a dataset of homologous sequences. The substitution matrices in popular use today are usually constructed without considerat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0529680e52cbde93b0bbcd21778cb925
https://doi.org/10.1002/prot.21775
https://doi.org/10.1002/prot.21775
Autor:
Byungkook Lee, Nalin C. W. Goonesekere
Publikováno v:
Nucleic Acids Research. 32:2838-2843
Gap penalty is an important component of the scoring scheme that is needed when searching for homologous proteins and for accurate alignment of protein sequences. Most homology search and sequence alignment algorithms employ a heuristic 'affine gap p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efb98656c5c2fcae2d05ce67e2b43a9e
https://doi.org/10.1093/nar/gkh610
https://doi.org/10.1093/nar/gkh610
Autor:
W. D. Ratnasooriya, Ralph Tiedemann, Maya B. Gunasekera, Himesha vandebona, Nalin C. W. Goonesekere
Publikováno v:
Mammalian Biology. 67:193-205
Summary The elephant population in Sri Lanka, estimated to be 4000, is currently fragmented and restricted mainly to a few elephant reserves. As a prerequisite for future conservation and management measures, this study aims at assessing the genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6517b4ad8e0e84a82dbad19163dc2bfa
https://doi.org/10.1078/1616-5047-00030
https://doi.org/10.1078/1616-5047-00030
Autor:
Yasantha Mapatuna, P.J.J. Bates, Nalin C. W. Goonesekere, W.D. Rathnasooriya, Maya B. Gunasekera
Publikováno v:
Mammalian Biology. 67:321-337
Summary The systematic and conservation status of the genus Cynopterus Cuvier, 1824, especially with regard to the status of C. sphinx Vahl, 1797 and C. brachyotis Muller, 1838, is still much in debate. The aim of this study was to conduct a comprehe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbd5341206bae36d298f83aa8c8f24bd
https://doi.org/10.1078/1616-5047-00049
https://doi.org/10.1078/1616-5047-00049