Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Nalan Utku"'
Autor:
Nicolas Krause, Jörg Mengwasser, Elpida Phithak, Francisca Beato, Marc Appis, Edgar Louis Milford, Johan Pratschke, Igor Sauer, Anja Kuehl, Arndt Vogel, Michael Goodyear, Linda Hammerich, Frank Tacke, Johanna Faith Haas, Tobias Müller, Nalan Utku
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
A subset of T regulatory cells (Tregs), identified by TIRC7 (T cell immune response cDNA 7) expression is designated as Immune Regulatory 1 Cells (IR1 cells). TIRC7 is an immune checkpoint inhibitor, co-localized with the T- cell receptor, HLA-DR and
Externí odkaz:
https://doaj.org/article/0b72a45ee2e44eeab2f1ef0229c3f46f
Autor:
Ulrich-Frank Pape, Oswald Burkhard, Nalan Utku, Karel Caca, Steffen Heeg, Ruza Arsenic, Lothar Mueller, Marianne Sinn, Anya A Kühl, Johannes Meiler, Holger Jansen, Arndt Vogel, Victor Rodriguez Laval, Stefan Kasper
264 Background: The novel drug EDO-S7.1 (CAP7.1) is converted to active etoposide by CES allowing administration of higher doses, reducing resistance, and permitting treatment of advanced tumors. Methods: The primary objective was to compare disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9884cad576c01a7ea15c3ebf4032cc29
Autor:
Marianne Sinn, Nalan Utku, T. Mehrling, Anja A. Kühl, Johannes Meiler, V. Rodriguez Laval, Ruza Arsenic, Karel Caca, Holger Jansen, S. Heeg, K. Hilgier, Arndt Vogel, Oswald Burkhard, Ulrich-Frank Pape, Stefan Kasper, Lothar Mueller, I. Wagner
Publikováno v:
Annals of Oncology. 30:v278
Background Etoposide toniribate (also known as EDO-S7.1, and previously known as CAP7.1), a novel topoisomerase II inhibitor, is activated in the presence of carboxylesterases. In specific tumor cell lines, it was found to be more active than etoposi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8ed1f2e2a469afb4dfeb3d88a975694
https://doi.org/10.1093/annonc/mdz247.051
https://doi.org/10.1093/annonc/mdz247.051
Autor:
Jordi Magrané, Nalan Utku, Manuel Guerreiro, Robert Kudernatsch, Sabrina Wilk, Sandra Bauer, Alexander Jenke, Carsten Skurk, Wolfgang Poller, Diana Elligsen-Merkel, H.-D. Volk, Madlen Rother, Carmen Scheibenbogen, Nicole Goerner
Publikováno v:
European Journal of Immunology. 41:2323-2332
Adiponectin (APN), a cytokine constitutively produced in fat tissue, has been shown to exert anti-inflammatory effects in various disease models. While the influence of APN on monocytic cells has been extensively studied in vitro, little is known abo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f24440d4a79a689d2b9ba8d9dc10391
https://doi.org/10.1002/eji.201041349
https://doi.org/10.1002/eji.201041349
Autor:
Ulrich Keilholz, Stefan Kasper, Ulrich-Frank Pape, Karel Caca, Jan Kuhlmann, Nalan Utku, Arndt Vogel, Marianne Sinn
441 Background: Non-resectable biliary tract cancers (BTC) have poor prognosis, but are chemosensitive. CAP7.1 is a new chemical entity that releases etoposide in the presence of carboxylesterases, leading to higher intra-tumor etoposide (E) with imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::860a1ebec0ea58f6d8c16652313821f1
Autor:
Nalan Utku, Ulrich Frank Pape
Publikováno v:
Journal of Multiple Sclerosis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::302f43a3429705e1625da0a4dbce4dd8
https://doi.org/10.4172/2376-0389.1000193
https://doi.org/10.4172/2376-0389.1000193
Autor:
Christopher E. Rudd, Sara Russell, Hideki Iijima, Takashi Nagaishi, Richard S. Blumberg, Nalan Utku, Atsushi Nakajima, Raktima Raychowdhury, Daohong Chen, Victor M. Morales
Publikováno v:
The Journal of Immunology. 172:3535-3543
Carcinoembryonic Ag-related cellular adhesion molecule 1 (CEACAM1) represents a group of transmembrane protein isoforms that consist of variable numbers of extracellular Ig-like domains together with either a long cytoplasmic (cyt) tail containing tw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ac048012345ba27f7b0b1bead2ac8fe
https://doi.org/10.4049/jimmunol.172.6.3535
https://doi.org/10.4049/jimmunol.172.6.3535
Autor:
Victor M. Morales, Andreas Christ, Suzanne M. Watt, Hyun S. Kim, Kevin W. Johnson, Nalan Utku, Ana M. Texieira, Atsushi Mizoguchi, Emiko Mizoguchi, Gary J. Russell, Sara E. Russell, Atul K. Bhan, Gordon J. Freeman, Richard S. Blumberg
Publikováno v:
The Journal of Immunology. 163:1363-1370
Human small intestinal intraepithelial lymphocytes (iIEL) are a unique population of CD8αβ+ TCR-αβ+ but CD28− T lymphocytes that may function in intestinal epithelial cell immunosurveillance. In an attempt to define novel cell surface molecules
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::819caa5ae853e0be1839b1ba467432bd
https://doi.org/10.4049/jimmunol.163.3.1363
https://doi.org/10.4049/jimmunol.163.3.1363
Autor:
Karel Caca, Glyn B. Steventon, Ulrich Frank Pape, Marianne Sinn, Jan Kuhlmann, Stefan Kasper, Lothar Mueller, Johannes Meiler, Matthias Machacek, Arndt Vogel, Ulrich Keilholz, Holger Jansen, Oswald Burkhard, Victor Rodriguez Laval, Nalan Utku
Publikováno v:
Journal of Clinical Oncology. 34:e15602-e15602
e15602Background: The aim of this study was to describe the population pharmacokinietics (PK) of CAP7.1, the prodrug of etoposide, and to describe how changes in total target lesion (TTL) size in b...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf691b33ef23214e279bb72bd8d8dbb3
https://doi.org/10.1200/jco.2016.34.15_suppl.e15602
https://doi.org/10.1200/jco.2016.34.15_suppl.e15602
Autor:
Mirko Schlawinsky, Thomas Heinemann, Hans-Dieter Volk, Richard S. Blumberg, M. Winter, Nalan Utku, Patricia A. Fraser, Edward E. S. Nieuwenhuis, C. G. Bulwin
Publikováno v:
Clinical & Experimental Immunology, 144, 142-151. Wiley-Blackwell Publishing Ltd
Summary TIRC7 is a cell surface molecule which is expressed in T and B lymphocytes and negatively regulates their function. Anti-TIRC7 specific monoclonal antibody (mAb) inhibited T cell memory response to recall antigens. Up-regulation of TIRC7 on l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f08177375eaf2273708ffc332bd587d3
https://europepmc.org/articles/PMC1809623/
https://europepmc.org/articles/PMC1809623/