An in vivo Pig Model for Testing Novel Positron Emission Tomography Radioligands Targeting Cerebral Protein Aggregates

Autor: Nakul Ravi Raval, Arafat Nasser, Clara Aabye Madsen, Natalie Beschorner, Emily Eufaula Beaman, Morten Juhl, Szabolcs Lehel, Mikael Palner, Claus Svarer, Pontus Plavén-Sigray, Louise Møller Jørgensen, Gitte Moos Knudsen

Publikováno v: Frontiers in Neuroscience, Vol 16 (2022)

Positron emission tomography (PET) has become an essential clinical tool for diagnosing neurodegenerative diseases with abnormal accumulation of proteins like amyloid-β or tau. Despite many attempts, it has not been possible to develop an appropriat

Externí odkaz: https://doaj.org/article/f482c8b7afce44d5bff90eb3d037684f

Kinetic models for estimating occupancy from single-scan PET displacement studies

Autor: Gjertrud Louise Laurell, Pontus Plavén-Sigray, Annette Johansen, Nakul Ravi Raval, Arafat Nasser, Clara Aabye Madsen, Jacob Madsen, Hanne Demant Hansen, Lene Lundgaard Donovan, Gitte Moos Knudsen, Adriaan A Lammertsma, R Todd Ogden, Claus Svarer, Martin Schain

Publikováno v: Laurell, G L, Plavén-Sigray, P, Johansen, A, Raval, N R, Nasser, A, Aabye Madsen, C, Madsen, J, Hansen, H D, Donovan, L L, Knudsen, G M, Lammertsma, A A, Ogden, R T, Svarer, C & Schain, M 2023, ' Kinetic models for estimating occupancy from single-scan PET displacement studies ', Journal of Cerebral Blood Flow and Metabolism . https://doi.org/10.1177/0271678X231168591
Journal of Cerebral Blood Flow and Metabolism. Nature Publishing Group

The traditional design of PET target engagement studies is based on a baseline scan and one or more scans after drug administration. We here evaluate an alternative design in which the drug is administered during an on-going scan (i.e., a displacemen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb8f95e56fbb9c6f1084263313de0b41
http://www.scopus.com/inward/record.url?scp=85153370411&partnerID=8YFLogxK

Evaluation of the α-synuclein PET radiotracer (d

Autor: Nakul Ravi, Raval, Clara Aabye, Madsen, Vladimir, Shalgunov, Arafat, Nasser, Umberto Maria, Battisti, Emily Eufaula, Beaman, Morten, Juhl, Louise Møller, Jørgensen, Matthias Manfred, Herth, Hanne Demant, Hansen, Pontus, Plavén-Sigray, Gitte Moos, Knudsen

Publikováno v: Nuclear medicine and biology.

A positron emission tomography (PET) radiotracer to neuroimage α-synuclein aggregates would be a crucial addition for early diagnosis and treatment development in disorders such as Parkinson's disease, where elevated aggregate levels are a histopath

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8edf976ac84129848ee66e4d4d561406
https://pubmed.ncbi.nlm.nih.gov/36095921

An in vivo pig model for testing novel PET radioligands targeting cerebral protein aggregates

Autor: Nakul Ravi Raval, Arafat Nasser, Clara Aabye Madsen, Natalie Beschorner, Emily Eufaula Beaman, Morten Juhl, Szabolcs Lehel, Mikael Palner, Claus Svarer, Pontus Plavén-Sigray, Louise Møller Jørgensen, Gitte Moos Knudsen

Positron emission tomography (PET) has become an essential clinical tool for diagnosing neurodegenerative diseases with abnormal accumulation of proteins like amyloid-β or tau. Despite many attempts, it has not been possible to develop an appropriat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fbb153895d97607447f7741a4f9d2f6f
https://doi.org/10.1101/2021.12.31.473908

Synaptic Density and Neuronal Metabolic Function Measured by Positron Emission Tomography in the Unilateral 6-OHDA Rat Model of Parkinson’s Disease

Autor: Matthias M. Herth, Ida Nymann Petersen, Nakul Ravi Raval, Mikael Palner, Frederik Gudmundsen, Patrick M. Fisher, Pontus Plavén-Sigray, Gitte M. Knudsen, Nikolaj Speth, Annesofie Videbæk, Morten Juhl, Ida Vang Andersen, Jens D. Mikkelsen

Publikováno v: Frontiers in Synaptic Neuroscience, Vol 13 (2021)
Raval, N R, Gudmundsen, F, Juhl, M, Andersen, I V, Speth, N, Videbæk, A, Petersen, I N, Mikkelsen, J D, Fisher, P M D, Herth, M M, Plavén-Sigray, P, Knudsen, G M & Palner, M 2021, ' Synaptic Density and Neuronal Metabolic Function Measured by Positron Emission Tomography in the Unilateral 6-OHDA Rat Model of Parkinson’s Disease ', Frontiers in Synaptic Neuroscience, vol. 13, 715811 . https://doi.org/10.3389/fnsyn.2021.715811
Frontiers in Synaptic Neuroscience

Parkinson’s disease (PD) is caused by progressive neurodegeneration and characterised by motor dysfunction. Neurodegeneration of dopaminergic neurons also causes aberrations within the cortico-striato-thalamo-cortical (CSTC) circuit, which has been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::216c52516384ff3a726fb0224014a675
https://www.frontiersin.org/articles/10.3389/fnsyn.2021.715811/full