Characterisation of mexiletine’s translational therapeutic index for suppression of ischaemia-induced ventricular fibrillation in the rat isolated heart

Autor: Catherine D. E. Wilder, Jade S. Munro, Michael J. Curtis, Nakita Ahdi, Georgia Lytra, Niraja N. Ranadive, Patrisia Qazimi, Louise M. Hesketh

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Hesketh, L M, Wilder, C D E, Ranadive, N N, Lytra, G, Qazimi, P, Munro, J S, Ahdi, N & Curtis, M J 2020, ' Characterisation of mexiletine’s translational therapeutic index for suppression of ischaemia-induced ventricular fibrillation in the rat isolated heart ', Scientific Reports, vol. 10, no. 1, 8397 . https://doi.org/10.1038/s41598-020-65190-y

The ‘translational therapeutic index’ (TTI) is a drug’s ratio of nonclinical threshold dose (or concentration) for significant benefit versus threshold for adversity. In early nonclinical research, discovery and safety studies are normally unde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2705f1dff92706d8102bcd236492d25
https://doi.org/10.1038/s41598-020-65190-y