Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Najwa Ouali Alami"'
Autor:
Salim Megat, Natalia Mora, Jason Sanogo, Olga Roman, Alberto Catanese, Najwa Ouali Alami, Axel Freischmidt, Xhuljana Mingaj, Hortense De Calbiac, François Muratet, Sylvie Dirrig-Grosch, Stéphane Dieterle, Nick Van Bakel, Kathrin Müller, Kirsten Sieverding, Jochen Weishaupt, Peter Munch Andersen, Markus Weber, Christoph Neuwirth, Markus Margelisch, Andreas Sommacal, Kristel R. Van Eijk, Jan H. Veldink, Project Mine Als Sequencing Consortium, Géraldine Lautrette, Philippe Couratier, Agnès Camuzat, Isabelle Le Ber, Maurizio Grassano, Adriano Chio, Tobias Boeckers, Albert C. Ludolph, Francesco Roselli, Deniz Yilmazer-Hanke, Stéphanie Millecamps, Edor Kabashi, Erik Storkebaum, Chantal Sellier, Luc Dupuis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-3 (2023)
Externí odkaz:
https://doaj.org/article/b08aebba67f346b6a340f3cc87fac551
Shank2 identifies a subset of glycinergic neurons involved in altered nociception in an autism model
Autor:
Florian Olde Heuvel, Najwa Ouali Alami, Oumayma Aousji, Esther Pogatzki-Zahn, Peter K. Zahn, Hanna Wilhelm, Dhruva Deshpande, Elmira Khatamsaz, Alberto Catanese, Sarah Woelfle, Michael Schön, Sanjay Jain, Stefanie Grabrucker, Albert C. Ludolph, Chiara Verpelli, Jens Michaelis, Tobias M. Boeckers, Francesco Roselli
Publikováno v:
Molecular Autism, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Background Autism Spectrum Disorders (ASD) patients experience disturbed nociception in the form of either hyposensitivity to pain or allodynia. A substantial amount of processing of somatosensory and nociceptive stimulus takes place in the
Externí odkaz:
https://doaj.org/article/bde43bf68ebe4d2c8f5a05d540104911
Autor:
Judith Stefanie Schlett, Melanie Mettang, Aladdin Skaf, Pavel Schweizer, Alina Errerd, Ephraim Alemayehu Mulugeta, Tabea Melissa Hein, Konstantinos Tsesmelis, Miltiadis Tsesmelis, Ulrike F. G. Büttner, Heinrich Wendt, Alireza Abaei, Volker Rasche, Vivien Prex, Ester Nespoli, Najwa Ouali Alami, Daniel Tews, Paul Walther, Deniz Yilmazer-Hanke, Franz Oswald, Leda Dimou, Thomas Wirth, Bernd Baumann
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-24 (2023)
Abstract Background Inflammaging represents an accepted concept where the immune system shifts to a low-grade chronic pro-inflammatory state without overt infection upon aging. In the CNS, inflammaging is mainly driven by glia cells and associated wi
Externí odkaz:
https://doaj.org/article/dadf10c5cb834709b7cfc8b0ca998b3f
Autor:
Salim Megat, Natalia Mora, Jason Sanogo, Olga Roman, Alberto Catanese, Najwa Ouali Alami, Axel Freischmidt, Xhuljana Mingaj, Hortense De Calbiac, François Muratet, Sylvie Dirrig-Grosch, Stéphane Dieterle, Nick Van Bakel, Kathrin Müller, Kirsten Sieverding, Jochen Weishaupt, Peter Munch Andersen, Markus Weber, Christoph Neuwirth, Markus Margelisch, Andreas Sommacal, Kristel R. Van Eijk, Jan H. Veldink, Project Mine Als Sequencing Consortium, Géraldine Lautrette, Philippe Couratier, Agnès Camuzat, Isabelle Le Ber, Maurizio Grassano, Adriano Chio, Tobias Boeckers, Albert C. Ludolph, Francesco Roselli, Deniz Yilmazer-Hanke, Stéphanie Millecamps, Edor Kabashi, Erik Storkebaum, Chantal Sellier, Luc Dupuis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Amyotrophic lateral sclerosis (ALS) has substantial heritability, in part shared with fronto-temporal dementia (FTD). We show that ALS heritability is enriched in splicing variants and in binding sites of 6 RNA-binding proteins including TDP
Externí odkaz:
https://doaj.org/article/6c41a4f4e8fe4f95afcbf96cee484c70
Autor:
Shu Yang, Alexander Magnutzki, Najwa Ouali Alami, Michael Lattke, Tabea Melissa Hein, Judith Stefanie Scheller, Carsten Kröger, Franz Oswald, Deniz Yilmazer-Hanke, Thomas Wirth, Bernd Baumann
Publikováno v:
Cells, Vol 10, Iss 10, p 2669 (2021)
Alzheimer’s disease (AD) is a common neurodegenerative disease that is accompanied by pronounced neuroinflammatory responses mainly characterized by marked microgliosis and astrogliosis. However, it remains open as to how different aspects of astro
Externí odkaz:
https://doaj.org/article/86b20a088cb54f49a99cefc0f3711239
Autor:
Matei Bolborea, Pauline Vercruysse, Tselmen Daria, Johanna C. Reiners, Najwa Ouali Alami, Simon J. Guillot, Stéphane Dieterlé, Jérôme Sinniger, Jelena Scekic-Zahirovic, Amela Londo, Hippolyte Arcay, Marc-Antoine Goy, Claudia Nelson de Tapia, Dietmar R. Thal, Kazumoto Shibuya, Ryo Otani, Kimihito Arai, Satoshi Kuwabara, Albert C. Ludolph, Francesco Roselli, Deniz Yilmazer-Hanke, Luc Dupuis
Publikováno v:
Acta neuropathologica 145(6), 773-791 (2023). doi:10.1007/s00401-023-02569-x
Amyotrophic lateral sclerosis (ALS) is associated with impaired energy metabolism, including weight loss and decreased appetite which are negatively correlated with survival. Neural mechanisms underlying metabolic impairment in ALS remain unknown. AL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f18d3d203fa3b8454fd5faf2f5793b7
https://lirias.kuleuven.be/handle/20.500.12942/719930
https://lirias.kuleuven.be/handle/20.500.12942/719930
Autor:
Jan H. Veldink, Edor Kabashi, Sylvie Dirrig-Grosch, Peter M Andersen, Najwa Ouali Alami, Luc Dupuis, Kirsten Sieverding, Axel Freischmidt, Natalia Mora, Albert C. Ludolph, Tobias M. Boeckers, Markus Margelisch, Philippe Couratier, Francesco Roselli, François Muratet, Andreas Sommacal, Chantal Sellier, Géraldine Lautrette, Erik Storkebaum, Markus Weber, Nick H.M. van Bakel, Stéphane Dieterlé, Stéphanie Millecamps, Kristel R. van Eijk, Jochen H. Weishaupt, Alberto Catanese, Kathrin Muller, Salim Megat, Xhuljana Mingaj, Christoph Neuwirth, Jason Sanogo, Hortense de Calbiac, Deniz Yilmazer-Hanke
The genetic basis of amyotrophic lateral sclerosis (ALS) is still incompletely understood. Using two independent genetic strategies, we show here that a large part of ALS heritability lies in genes expressed in inhibitory and excitatory neurons, espe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a41e6326cbbfff9095abfc6e283f98d4
https://doi.org/10.1101/2021.08.23.21262299
https://doi.org/10.1101/2021.08.23.21262299
Autor:
Daniel Zytnicki, Marcin Bączyk, Nicolas Doisne, Clémence Martinot, Najwa Ouali Alami, Barbara Commisso, Nicolas Delestrée, Francesco Roselli, David Bayer, Marin Manuel, Linyun Tang, Wayne N. Frankel
Publikováno v:
Journal of Experimental Medicine
Journal of Experimental Medicine, Rockefeller University Press, 2020, 217 (8), ⟨10.1084/jem.20191734⟩
The Journal of Experimental Medicine
Journal of experimental medicine 217(8), e20191734 (2020). doi:10.1084/jem.20191734
Journal of Experimental Medicine, Rockefeller University Press, 2020, 217 (8), ⟨10.1084/jem.20191734⟩
The Journal of Experimental Medicine
Journal of experimental medicine 217(8), e20191734 (2020). doi:10.1084/jem.20191734
This study demonstrates that, in a mouse model of ALS, excitatory synapses on spinal motoneurons are disrupted. Activation of the cAMP/PKA pathway reverts the functional and structural synaptic deficits and ameliorates disease markers by increasing m
Autor:
Phillip C. Wong, Diana Wiesner, Francesco Roselli, Tobias M. Boeckers, Deniz Yilmazer-Hanke, Barbara Commisso, Linyun Tang, Albert C. Ludolph, Jochen H. Weishaupt, Najwa Ouali Alami, Luc Dupuis, David Bayer, Bernd Baumann, Thomas Wirth
Publikováno v:
Life science alliance 3(11), e201900571 (2020). doi:10.26508/lsa.201900571
Life Science Alliance
Life Science Alliance, Life Science Alliance LLC, 2020, 3 (11), pp.e201900571. ⟨10.26508/lsa.201900571⟩
Life Science Alliance, 2020, 3 (11), pp.e201900571. ⟨10.26508/lsa.201900571⟩
Life Science Alliance
Life Science Alliance, Life Science Alliance LLC, 2020, 3 (11), pp.e201900571. ⟨10.26508/lsa.201900571⟩
Life Science Alliance, 2020, 3 (11), pp.e201900571. ⟨10.26508/lsa.201900571⟩
Chemogenetic motoneuron excitation and astrocyte GPCR-Gi signaling restore blood–spinal cord barrier, disrupted in four ALS mouse models, revealing its role in disease progression but not initiation.
Blood–spinal cord barrier (BSCB) disrupti
Blood–spinal cord barrier (BSCB) disrupti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93218dfe1100975b7bc1fb24ea761df4
https://pub.dzne.de/record/164314
https://pub.dzne.de/record/164314
NF‐κB activation in astrocytes drives a stage‐specific beneficial neuroimmunological response in ALS
Autor:
Thomas Wirth, Benno Rothenhäusler, Qian Li, Irene Knuesel, Uwe Grether, Matthias Nettekoven, Christine Schurr, Albert C. Ludolph, Christoph Ullmer, Bernd Baumann, Catarina Raposo, Najwa Ouali Alami, Giorgio Ottaviani, Linyun Tang, Alpaslan Tasdogan, Francesco Roselli, Jürgen Fingerle, Tobias M. Boeckers, Mark Rogers-Evans, Atsushi Kimbara, Stephan Röver, Florian olde Heuvel
Publikováno v:
The EMBO Journal
Astrocytes are involved in non-cell-autonomous pathogenic cascades in amyotrophic lateral sclerosis (ALS); however, their role is still debated. We show that astrocytic NF-κB activation drives microglial proliferation and leukocyte infiltration in t