EPIGENETIC AND GENETIC DETERMINANTS OF ENDOMETRIAL HYPERPLASTIC PROCESSES IN PERIMENOPAUSAL OBESE WOMEN

Autor: Najmutdinova D., K., Kayumova D., T., Babaev A., T., Yuldasheva D. Yu., Sadikova, D.R., Choriyeva, G.Z.

Endometrial hyperplasia (EH) in perimenopause is almost always accompanied by abnormal uterine bleeding (AUB), the nature of which is due to hormonal, biochemical, molecular genetics, and local violation of the regulation of cell proliferation. The a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::430a24da8ee59154b811097d9b604c8d

Variants in the fetal genome near FLT1 are associated with risk of preeclampsia

Autor: McGinnis, R, Steinthorsdottir, V, Williams, NO, Thorleifsson, G, Shooter, S, Hjartardottir, S, Bumpstead, S, Stefansdottir, L, Hildyard, L, Sigurdsson, JK, Kemp, JP, Silva, GB, Thomsen, LCV, Jääskeläinen, T, Kajantie, E, Chappell, S, Kalsheker, N, Moffett, A, Hiby, S, Lee, WK, Padmanabhan, S, Simpson, NAB, Dolby, VA, Staines-Urias, E, Engel, SM, Haugan, A, Trogstad, L, Svyatova, G, Zakhidova, N, Najmutdinova, D, FINNPEC Consortium, GOPEC Consortium, Dominiczak, AF, Gjessing, HK, Casas, JP, Dudbridge, F, Walker, JJ, Pipkin, FB, Thorsteinsdottir, U, Geirsson, RT, Lawlor, DA, Iversen, AC, Magnus, P, Laivuori, H, Stefansson, K, Morgan, L, COLLABORATORS, Heinonen, S, Kere, J, Kivinen, K, Pouta, A, Macphail, S, Kilby, M, Habiba, M, Williamson, C, O'Shaughnessy, K, O'Brien, S, Cameron, A, Poston, L, Miedzybrodzka, Z, Redman, CWG, Farrall, M, Caulfield, M

Preeclampsia, which affects approximately 5% of pregnancies, is a leading cause of maternal and perinatal death. The causes of preeclampsia remain unclear, but there is evidence for inherited susceptibility. Genome-wide association studies (GWAS) hav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::7abdaaa035f04d8c4f6b44daca99f63f

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Variants in the fetal genome near FLT1 are associated with risk of preeclampsia.

Autor: McGinnis R; Wellcome Trust Sanger Institute, Cambridge, UK., Steinthorsdottir V; deCODE Genetics/Amgen, Reykjavik, Iceland., Williams NO; Wellcome Trust Sanger Institute, Cambridge, UK., Thorleifsson G; deCODE Genetics/Amgen, Reykjavik, Iceland., Shooter S; Wellcome Trust Sanger Institute, Cambridge, UK., Hjartardottir S; Department of Obstetrics and Gynecology, Landspitali University Hospital, Reykjavik, Iceland., Bumpstead S; Wellcome Trust Sanger Institute, Cambridge, UK., Stefansdottir L; deCODE Genetics/Amgen, Reykjavik, Iceland., Hildyard L; Wellcome Trust Sanger Institute, Cambridge, UK., Sigurdsson JK; deCODE Genetics/Amgen, Reykjavik, Iceland., Kemp JP; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.; University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia., Silva GB; Centre of Molecular Inflammation Research (CEMIR) and Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.; St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Thomsen LCV; Centre of Molecular Inflammation Research (CEMIR) and Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway., Jääskeläinen T; Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Kajantie E; National Institute for Health and Welfare, Helsinki, Finland.; Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; PEDEGO Research Unit, Oulu University Hospital and University of Oulu, Oulu, Finland., Chappell S; School of Life Sciences, University of Nottingham, Nottingham, UK., Kalsheker N; School of Life Sciences, University of Nottingham, Nottingham, UK., Moffett A; Department of Pathology, University of Cambridge, Cambridge, UK., Hiby S; Department of Pathology, University of Cambridge, Cambridge, UK., Lee WK; BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK., Padmanabhan S; BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK., Simpson NAB; Leeds Institute of Biomedical and Clinical Sciences, University of Leeds, Leeds, UK., Dolby VA; Leeds Institute of Biomedical and Clinical Sciences, University of Leeds, Leeds, UK., Staines-Urias E; Department of Non-communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.; Nuffield Department of Obstetrics &Gynaecology, University of Oxford, Oxford, UK., Engel SM; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA., Haugan A; Norwegian Institute of Public Health, Oslo, Norway., Trogstad L; Norwegian Institute of Public Health, Oslo, Norway., Svyatova G; Scientific Center of Obstetrics, Gynecology and Perinatology, Almaty, Kazakhstan., Zakhidova N; Institute of Immunology, Uzbek Academy of Sciences, Tashkent, Uzbekistan., Najmutdinova D; Republic Specialized Scientific Practical Medical Centre of Obstetrics and Gynecology, Tashkent, Uzbekistan., Dominiczak AF; BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK., Gjessing HK; Norwegian Institute of Public Health, Oslo, Norway.; Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway., Casas JP; Farr Institute of Health Informatics, University College London, London, UK., Dudbridge F; Department of Non-communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK., Walker JJ; Leeds Institute of Biomedical and Clinical Sciences, University of Leeds, Leeds, UK., Pipkin FB; Medical School, University of Nottingham, Nottingham, UK., Thorsteinsdottir U; deCODE Genetics/Amgen, Reykjavik, Iceland.; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland., Geirsson RT; Department of Obstetrics and Gynecology, Landspitali University Hospital, Reykjavik, Iceland., Lawlor DA; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.; School of Social and Community Medicine, University of Bristol, Bristol, UK., Iversen AC; Centre of Molecular Inflammation Research (CEMIR) and Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway., Magnus P; Norwegian Institute of Public Health, Oslo, Norway., Laivuori H; Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Stefansson K; deCODE Genetics/Amgen, Reykjavik, Iceland.; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland., Morgan L; School of Life Sciences, University of Nottingham, Nottingham, UK.

Publikováno v: Nature genetics [Nat Genet] 2017 Aug; Vol. 49 (8), pp. 1255-1260. Date of Electronic Publication: 2017 Jun 19.