Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Najmeh, Edraki"'
Autor:
Aida Iraji, Parisa Nikfar, Mohammad Nazari Montazer, Mona Karimi, Najmeh Edraki, Mina Saeedi, Seyedeh Sara Mirfazli
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that affects the elderly population globally and there is an urgent demand for developing novel anti-AD agents. In this study, a new series of indole-isoxazole carbohydra
Externí odkaz:
https://doaj.org/article/0b92848d63f94429b238c223428f7085
Autor:
Maryam Firouzi, Zahra Haghighijoo, Masoomeh Eskandari, Maryam Mohabbati, Ramin Miri, Mohammad Hasan Jamei, Alireza Poustforoosh, Somayeh Nazari, Omidreza Firuzi, Mehdi Khoshneviszadeh, Najmeh Edraki
Publikováno v:
BMC Chemistry, Vol 18, Iss 1, Pp 1-16 (2024)
Abstract Two series of novel imidazo[1,2-a]pyridine-2-carbohydrazide derivatives have been designed, synthesized, and evaluated for cytotoxic activity. Target compounds were designed in two series: aryl hydrazone derivatives that were devoid of triaz
Externí odkaz:
https://doaj.org/article/b3857a4241ff4145bf0fa7257831487f
Autor:
Motahareh Mortazavi, Masoomeh Eskandari, Fatemeh Moosavi, Tahereh Damghani, Mehdi Khoshneviszadeh, Somayeh Pirhadi, Luciano Saso, Najmeh Edraki, Omidreza Firuzi
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract Oncogenic activation of receptor tyrosine kinases (RTKs) such as MET is associated with cancer initiation and progression. We designed and synthesized a new series of quinazoline derivatives bearing 1,2,3-triazole moiety as targeted anticanc
Externí odkaz:
https://doaj.org/article/c1443f8e9a85470f9474abe6d0ecf7b6
Autor:
Mina Saeedi, Aida Iraji, Yasaman Vahedi-Mazdabadi, Atiyeh Alizadeh, Najmeh Edraki, Omidreza Firuzi, Mahdieh Eftekhari, Tahmineh Akbarzadeh
Publikováno v:
BMC Complementary Medicine and Therapies, Vol 22, Iss 1, Pp 1-11 (2022)
Abstract Background Cinnamomum verum J. Presl. (Lauraceae), Myrtus communis L. (Myrtaceae), Ruta graveolens L. (Rutaaceae), Anethum graveolens L. (Apiaceae), Myristica fragrans Houtt. (Myristicaceae), and Crocus sativus L. (Iridaceae) have been recom
Externí odkaz:
https://doaj.org/article/86a5b6f8cd8e46d4b73fdaa7cd3342c8
Autor:
Motahareh Mortazavi, Masoumeh Divar, Tahereh Damghani, Fatemeh Moosavi, Luciano Saso, Somayeh Pirhadi, Mehdi Khoshneviszadeh, Najmeh Edraki, Omidreza Firuzi
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
The advent of novel receptor tyrosine kinase inhibitors has provided an important therapeutic tool for cancer patients. In this study, a series of quinazolinone hydrazide triazole derivatives were designed and synthesized as novel MET (c-MET) recepto
Externí odkaz:
https://doaj.org/article/cf100fbfe3654206af7467a5ea561e43
Autor:
Tahereh Damghani, Fatemeh Moosavi, Mehdi Khoshneviszadeh, Motahareh Mortazavi, Somayeh Pirhadi, Zahra Kayani, Luciano Saso, Najmeh Edraki, Omidreza Firuzi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)
Abstract Aberrant activation of c-Met signalling plays a prominent role in cancer development and progression. A series of 12 imidazo [1,2-α] pyridine derivatives bearing 1,2,3-triazole moiety were designed, synthesized and evaluated for c-Met inhib
Externí odkaz:
https://doaj.org/article/e84ba50f01d64642a71fc85adbc1b611
Autor:
Sara Ranjbar, Mehraneh Kamarei, Mahsima Khoshneviszadeh, Hona Hosseinpoor, Najmeh Edraki, Mehdi Khoshneviszadeh
Publikováno v:
Research in Pharmaceutical Sciences, Vol 16, Iss 4, Pp 425-435 (2021)
Background and purpose: Tyrosinase enzyme has a key role in melanin biosynthesis by converting tyrosine into dopaquinone. It also participates in the enzymatic browning of vegetables by polyphenol oxidation. Therefore, tyrosinase inhibitors are usefu
Externí odkaz:
https://doaj.org/article/44415d22697346b19677f53bb3d2f628
Autor:
Aida Iraji, Ali Nemati, Hona Hosseinpoor, Najmeh Edraki, mahsima Khoshneviszadeh, Mahshid Attarroshan, Hossein Sadeghpour, Mehdi Khoshneviszadeh
Publikováno v:
Trends in Pharmaceutical Sciences, Vol 6, Iss 4, Pp 233-242 (2020)
Melanogenesis is a process of melanin synthesize, which is a primary response for the pigmentation of human skin. Tyrosinase is a key enzyme, which catalyzes a rate-limiting step of the melanin formation, natural products have shown potent inhibitors
Externí odkaz:
https://doaj.org/article/83ab6015bf13431b8f47cd82ec4e097d
Autor:
Aida Iraji, Tina Adelpour, Najmeh Edraki, Mahsima Khoshneviszadeh, Ramin Miri, Mehdi Khoshneviszadeh
Publikováno v:
BMC Chemistry, Vol 14, Iss 1, Pp 1-11 (2020)
Abstract In this work, 11 novel compounds based on vaniline and benzylidenehydrazine structure were synthesized with various substituents on phenyl aromatic ring of the molecule and evaluated as tyrosinase inhibitors. These new derivatives showed sig
Externí odkaz:
https://doaj.org/article/f95dcd415a7740d78be0d12fdc3292bd
Autor:
Najmeh Edraki, Mojtaba Asadollahi, Hajar Hemmatian, Mehdi Khoshneviszadeh, Omidreza Firuzi, Amirhossein Sakhteman, Amireza Jasbi
Publikováno v:
Iranian South Medical Journal, Vol 22, Iss 4, Pp 191-199 (2019)
Background: Given the importance of Stachys genus in Iran and their significant biological activity, we collected three species of this plant: St. aucheri Benth., Stachys benthamiana Boiss and St. inflata Benth. from different regions of Iran. We exa
Externí odkaz:
https://doaj.org/article/14a97898368b432c9cbe8c6edf8cde42