Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Najma Latif"'
Autor:
Magdi H. Yacoub, Yuan-Tsan Tseng, Jolanda Kluin, Annemijn Vis, Ulrich Stock, Hassiba Smail, Padmini Sarathchandra, Elena Aikawa, Hussam El-Nashar, Adrian H. Chester, Nairouz Shehata, Mohamed Nagy, Amr El-sawy, Wei Li, Gaetano Burriesci, Jacob Salmonsmith, Soha Romeih, Najma Latif
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
Abstract Heart valve disease is a major cause of mortality and morbidity worldwide with no effective medical therapy and no ideal valve substitute emulating the extremely sophisticated functions of a living heart valve. These functions influence surv
Externí odkaz:
https://doaj.org/article/2f4de43f32a048168f38d511ee2a0394
Autor:
Sarah Halawa, Najma Latif, Yuan-Tsan Tseng, Ayman M. Ibrahim, Adrian H. Chester, Ahmed Moustafa, Yasmine Aguib, Magdi H. Yacoub
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Cardiac valves exhibit highly complex structures and specialized functions that include dynamic interactions between cells, extracellular matrix (ECM) and their hemodynamic environment. Valvular gene expression is tightly regulated by a variety of me
Externí odkaz:
https://doaj.org/article/67db120321ee4ce9b4bb65f9cb0a44b2
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
ObjectiveWe have previously reported that human calcified aortic cusps have abundant expression of smooth muscle (SM) markers and co-activators. We hypothesised that cells in bicuspid aortic valve (BAV) cusps and those affected by rheumatic heart val
Externí odkaz:
https://doaj.org/article/8cc065ee95e646978808c076c6b4ad6e
Autor:
Yuan-Tsan Tseng, Nabil F. Grace, Heba Aguib, Padmini Sarathchandra, Ann McCormack, Ahmed Ebeid, Nairouz Shehata, Mohamed Nagy, Hussam El-Nashar, Magdi H. Yacoub, Adrian Chester, Najma Latif
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
The success of tissue-engineered heart valves rely on a balance between polymer degradation, appropriate cell repopulation, and extracellular matrix (ECM) deposition, in order for the valves to continue their vital function. However, the process of r
Externí odkaz:
https://doaj.org/article/6a75da45e3e64689b220ba3ea0ce225e
Autor:
Hessah Al-Shammari, Najma Latif, Padmini Sarathchandra, Ann McCormack, Eva A Rog-Zielinska, Shahzad Raja, Peter Kohl, Magdi H Yacoub, Rémi Peyronnet, Adrian H Chester
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0240532 (2020)
BackgroundThe ability of heart valve cells to respond to their mechanical environment represents a key mechanism by which the integrity and function of valve cusps is maintained. A number of different mechanotransduction pathways have been implicated
Externí odkaz:
https://doaj.org/article/79c086a05be1422ea0e3e74733bd6ff0
Autor:
Ana M. Porras, Nicole C. A. van Engeland, Evelyn Marchbanks, Ann McCormack, Carlijn V. C. Bouten, Magdi H. Yacoub, Najma Latif, Kristyn S. Masters
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 3 (2017)
Background Valvular interstitial cells (VICs) in the healthy aortic valve leaflet exhibit a quiescent phenotype, with 90% of cells. The inability to preserve a healthy VIC phenotype during in vitro studies has hampered the elucidation of mechanisms i
Externí odkaz:
https://doaj.org/article/05a0616e485d4c96acab8808b7b167d0
Autor:
Najma Latif, Alfred Quillon, Padmini Sarathchandra, Ann McCormack, Alec Lozanoski, Magdi H Yacoub, Adrian H Chester
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0127844 (2015)
Valve interstitial cells (VICs) are fibroblastic in nature however in culture it is widely accepted that they differentiate into a myofibroblastic phenotype. This study assessed a fibroblast culture media formulation for its ability to maintain the p
Externí odkaz:
https://doaj.org/article/90492c2850614a02b787ba25318e106e
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 4, Iss 4, p e661 (2010)
BackgroundEndomyocardial Fibrosis (EMF) is a tropical restrictive cardiomyopathy of unknown etiology with high prevalence in Sub-Saharan Africa, for which it is unclear whether the primary target of injury is the endocardial endothelium, the subendoc
Externí odkaz:
https://doaj.org/article/fdc723fb100f4affa50a319c0a936e36
Autor:
Worood A. El-Mehalmey, Najma Latif, Ahmed H. Ibrahim, Rana R. Haikal, Paulina Mierzejewska, Ryszard T. Smolenski, Magdi H. Yacoub, Mohamed H. Alkordi
Publikováno v:
Biomaterials Science. 10:1342-1351
Adenosine is a small molecule directly involved in maintaining homeostasis under pathological and stressful conditions. Due to its rapid metabolism, delivery vehicles capable of exhibiting extended release of adenosine are of paramount interest. Here
Autor:
Magdi Yacoub, Yuan-Tsan Tseng, Jolanda Kluin, Annemijn Vis, Ulrich Stock, Hassiba Smail, Padmini Sarathchandra, Elena Aikawa, Hussam El-Nashar, Adrian Chester, Nairouz Shehata, Mohamed Nagy, Amr El-sawy, Gaetano Burriesci, Jacob Salmonsmith, Soha Romeih, Najma Latif
Heart valve disease is a major cause of mortality and morbidity worldwide with no effective medical therapy and no ideal valve substitute emulating the extremely sophisticated functions of a living heart valve. These functions influence survival and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3e6f8b32dbcfa04d7c6f9f9261bd23a
https://doi.org/10.21203/rs.3.rs-2322351/v1
https://doi.org/10.21203/rs.3.rs-2322351/v1