Exposure to halogenated ethers causes neurodegeneration and behavioural changes in young healthy experimental animals: a systematic review and meta analyses

Autor: Carlijn R. Hooijmans, Marije Buijs, Frederique Struijs, Thijs Som, Najma Karim, Gert-Jan Scheffer, Ignacio Malagon

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-18 (2023)

Abstract The FDA issued a warning that repeated and prolonged use of inhalational anaesthetics in children younger than 3 years may increase the risk of neurological damage. Robust clinical evidence supporting this warning is however lacking. A syste

Externí odkaz: https://doaj.org/article/ae16a42b096e4558a9b54ff83f644aa0

Nα-Methylhistamine: association with Helicobacter pylori infection in humans and effects on gastric acid secretion

Autor: Stephen Murray, John Calam, Graham W. Taylor, Q. Najma Karim, PW Bliss

Publikováno v: Clinica Chimica Acta. 301:181-192

Infection with the bacterium Helicobacter pylori is associated with altered gastric acid secretion and gastrointestinal disease. Recent work has suggested that N alpha-methylhistamine, produced by the bacterium and acting on histamine receptors in ga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85c8244379006a75460bf5485b4f02ca
https://doi.org/10.1016/s0009-8981(00)00357-0

Helicobacter pylori flagellar hook-filament transition is controlled by a FliK functional homolog encoded by the gene HP0906

Autor: M. Worku, Charles W. Penn, Najma Karim, Kieran A. Ryan, Paul W. O'Toole

Publikováno v: Journal of bacteriology. 187(16)

Helicobacter pylori is a human gastric pathogen which is dependent on motility for infection. The H. pylori genome encodes a near-complete complement of flagellar proteins compared to model enteric bacteria. One of the few flagellar genes not annotat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbed723e9ff19b570f8cae97c1bb183b
https://pubmed.ncbi.nlm.nih.gov/16077121

Variations in Helicobacter pylori lipopolysaccharide to evade the innate immune component surfactant protein D

Autor: Marjorie M. Walker, Ben J. Appelmelk, Kenneth B.M. Reid, Wafa Khamri, Mark Thursz, Heidi Annuk, Paul Eggleton, John A. Ferris, Anthony P. Moran, M. Worku, Q. Najma Karim

Publikováno v: Infection and Immunity, 73(11), 7677-7686. American Society for Microbiology
Khamri, W, Moran, A P, Worku, M L, Karim, Q N, Walker, M M, Annuk, H, Ferris, J A, Appelmelk, B J, Eggleton, P, Reid, K B & Thursz, M R 2005, ' Variations in Helicobacter pylori lipopolysaccharide to evade the innate immune component surfactant protein D ', Infection and Immunity, vol. 73, no. 11, pp. 7677-7686 . https://doi.org/10.1128/IAI.73.11.7677-7686.2005

Helicobacter pyloriis a common and persistent human pathogen of the gastric mucosa. Surfactant protein D (SP-D), a component of innate immunity, is expressed in the human gastric mucosa and is capable of aggregatingH. pylori. Wide variation in the SP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c09a000e6f0d0e075ec0b43473bf45da
https://research.vumc.nl/en/publications/9bea4834-358a-41a7-a5d5-9bb9b8fa7706

Expression of surfactant protein D in the human gastric mucosa and during Helicobacter pylori infection

Autor: Mulegata Worku, John A. Ferris, Paul Eggleton, Anthony P. Moran, Mark Thursz, Q. Najma Karim, Wafa Khamri, Susanne Knapp, Peter Strong, Kenneth B.M. Reid, Emma Murray, Marjorie M. Walker

Publikováno v: Infection and immunity. 70(3)

Helicobacterpyloriestablishes persistent infection of gastric mucosa with diverse clinical outcomes. The innate immune molecule surfactant protein D (SP-D) binds selectively to microorganisms, inducing aggregation and phagocytosis. In this study, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c20fc5f775643cda3a821eac3f38e2fb
https://pubmed.ncbi.nlm.nih.gov/11854236