Creation of a Peptide Antagonist of the GFRAL-RET Receptor Complex for the Treatment of GDF15-Induced Malaise.

Autor: Borner T; Department of Biobehavioral Health Sciences, School of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States., Tinsley IC; Department of Chemistry, Syracuse University, 111 College Place, Syracuse, New York 13244, United States., Milliken BT; Department of Chemistry, Syracuse University, 111 College Place, Syracuse, New York 13244, United States., Doebley SA; Department of Biobehavioral Health Sciences, School of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States., Najjar NR; Department of Chemistry, Syracuse University, 111 College Place, Syracuse, New York 13244, United States., Kerwood DJ; Department of Chemistry, Syracuse University, 111 College Place, Syracuse, New York 13244, United States., De Jonghe BC; Department of Biobehavioral Health Sciences, School of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States., Hayes MR; Department of Biobehavioral Health Sciences, School of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States., Doyle RP; Department of Chemistry, Syracuse University, 111 College Place, Syracuse, New York 13244, United States.; Departments of Medicine and Pharmacology, State University of New York, Upstate Medical University, Syracuse, New York 13245, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2023 Aug 24; Vol. 66 (16), pp. 11237-11249. Date of Electronic Publication: 2023 Jul 28.