Ultrasound Blood-Brain Barrier Opening and Aducanumab in Alzheimer's Disease.

Autor: Rezai AR; From the Departments of Neurosurgery (A.R.R., P.-F.D., M.R.), Neuroradiology (P.-F.D., J.C., R.I.M., P.W., A.T.), Neuroscience (A.R.R., V.F., C.V.L.T., T.A., P.T., M.W.H., R.I.M.), Neurology (K.W., U.N., M.W.H.), and Behavioral Medicine and Psychiatry (M.W.H.), Rockefeller Neuroscience Institute, Department of Medicine (S.H.), and West Virginia Clinical and Translational Science Institute (S.H.), West Virginia University, Morgantown; and the Department of Neurology, Vanderbilt University, Nashville (D.O.C.)., D'Haese PF; From the Departments of Neurosurgery (A.R.R., P.-F.D., M.R.), Neuroradiology (P.-F.D., J.C., R.I.M., P.W., A.T.), Neuroscience (A.R.R., V.F., C.V.L.T., T.A., P.T., M.W.H., R.I.M.), Neurology (K.W., U.N., M.W.H.), and Behavioral Medicine and Psychiatry (M.W.H.), Rockefeller Neuroscience Institute, Department of Medicine (S.H.), and West Virginia Clinical and Translational Science Institute (S.H.), West Virginia University, Morgantown; and the Department of Neurology, Vanderbilt University, Nashville (D.O.C.)., Finomore V; From the Departments of Neurosurgery (A.R.R., P.-F.D., M.R.), Neuroradiology (P.-F.D., J.C., R.I.M., P.W., A.T.), Neuroscience (A.R.R., V.F., C.V.L.T., T.A., P.T., M.W.H., R.I.M.), Neurology (K.W., U.N., M.W.H.), and Behavioral Medicine and Psychiatry (M.W.H.), Rockefeller Neuroscience Institute, Department of Medicine (S.H.), and West Virginia Clinical and Translational Science Institute (S.H.), West Virginia University, Morgantown; and the Department of Neurology, Vanderbilt University, Nashville (D.O.C.)., Carpenter J; From the Departments of Neurosurgery (A.R.R., P.-F.D., M.R.), Neuroradiology (P.-F.D., J.C., R.I.M., P.W., A.T.), Neuroscience (A.R.R., V.F., C.V.L.T., T.A., P.T., M.W.H., R.I.M.), Neurology (K.W., U.N., M.W.H.), and Behavioral Medicine and Psychiatry (M.W.H.), Rockefeller Neuroscience Institute, Department of Medicine (S.H.), and West Virginia Clinical and Translational Science Institute (S.H.), West Virginia University, Morgantown; and the Department of Neurology, Vanderbilt University, Nashville (D.O.C.)., Ranjan M; From the Departments of Neurosurgery (A.R.R., P.-F.D., M.R.), Neuroradiology (P.-F.D., J.C., R.I.M., P.W., A.T.), Neuroscience (A.R.R., V.F., C.V.L.T., T.A., P.T., M.W.H., R.I.M.), Neurology (K.W., U.N., M.W.H.), and Behavioral Medicine and Psychiatry (M.W.H.), Rockefeller Neuroscience Institute, Department of Medicine (S.H.), and West Virginia Clinical and Translational Science Institute (S.H.), West Virginia University, Morgantown; and the Department of Neurology, Vanderbilt University, Nashville (D.O.C.)., Wilhelmsen K; From the Departments of Neurosurgery (A.R.R., P.-F.D., M.R.), Neuroradiology (P.-F.D., J.C., R.I.M., P.W., A.T.), Neuroscience (A.R.R., V.F., C.V.L.T., T.A., P.T., M.W.H., R.I.M.), Neurology (K.W., U.N., M.W.H.), and Behavioral Medicine and Psychiatry (M.W.H.), Rockefeller Neuroscience Institute, Department of Medicine (S.H.), and West Virginia Clinical and Translational Science Institute (S.H.), West Virginia University, Morgantown; and the Department of Neurology, Vanderbilt University, Nashville (D.O.C.)., Mehta RI; From the Departments of Neurosurgery (A.R.R., P.-F.D., M.R.), Neuroradiology (P.-F.D., J.C., R.I.M., P.W., A.T.), Neuroscience (A.R.R., V.F., C.V.L.T., T.A., P.T., M.W.H., R.I.M.), Neurology (K.W., U.N., M.W.H.), and Behavioral Medicine and Psychiatry (M.W.H.), Rockefeller Neuroscience Institute, Department of Medicine (S.H.), and West Virginia Clinical and Translational Science Institute (S.H.), West Virginia University, Morgantown; and the Department of Neurology, Vanderbilt University, Nashville (D.O.C.)., Wang P; From the Departments of Neurosurgery (A.R.R., P.-F.D., M.R.), Neuroradiology (P.-F.D., J.C., R.I.M., P.W., A.T.), Neuroscience (A.R.R., V.F., C.V.L.T., T.A., P.T., M.W.H., R.I.M.), Neurology (K.W., U.N., M.W.H.), and Behavioral Medicine and Psychiatry (M.W.H.), Rockefeller Neuroscience Institute, Department of Medicine (S.H.), and West Virginia Clinical and Translational Science Institute (S.H.), West Virginia University, Morgantown; and the Department of Neurology, Vanderbilt University, Nashville (D.O.C.)., Najib U; From the Departments of Neurosurgery (A.R.R., P.-F.D., M.R.), Neuroradiology (P.-F.D., J.C., R.I.M., P.W., A.T.), Neuroscience (A.R.R., V.F., C.V.L.T., T.A., P.T., M.W.H., R.I.M.), Neurology (K.W., U.N., M.W.H.), and Behavioral Medicine and Psychiatry (M.W.H.), Rockefeller Neuroscience Institute, Department of Medicine (S.H.), and West Virginia Clinical and Translational Science Institute (S.H.), West Virginia University, Morgantown; and the Department of Neurology, Vanderbilt University, Nashville (D.O.C.)., Vieira Ligo Teixeira C; From the Departments of Neurosurgery (A.R.R., P.-F.D., M.R.), Neuroradiology (P.-F.D., J.C., R.I.M., P.W., A.T.), Neuroscience (A.R.R., V.F., C.V.L.T., T.A., P.T., M.W.H., R.I.M.), Neurology (K.W., U.N., M.W.H.), and Behavioral Medicine and Psychiatry (M.W.H.), Rockefeller Neuroscience Institute, Department of Medicine (S.H.), and West Virginia Clinical and Translational Science Institute (S.H.), West Virginia University, Morgantown; and the Department of Neurology, Vanderbilt University, Nashville (D.O.C.)., Arsiwala T; From the Departments of Neurosurgery (A.R.R., P.-F.D., M.R.), Neuroradiology (P.-F.D., J.C., R.I.M., P.W., A.T.), Neuroscience (A.R.R., V.F., C.V.L.T., T.A., P.T., M.W.H., R.I.M.), Neurology (K.W., U.N., M.W.H.), and Behavioral Medicine and Psychiatry (M.W.H.), Rockefeller Neuroscience Institute, Department of Medicine (S.H.), and West Virginia Clinical and Translational Science Institute (S.H.), West Virginia University, Morgantown; and the Department of Neurology, Vanderbilt University, Nashville (D.O.C.)., Tarabishy A; From the Departments of Neurosurgery (A.R.R., P.-F.D., M.R.), Neuroradiology (P.-F.D., J.C., R.I.M., P.W., A.T.), Neuroscience (A.R.R., V.F., C.V.L.T., T.A., P.T., M.W.H., R.I.M.), Neurology (K.W., U.N., M.W.H.), and Behavioral Medicine and Psychiatry (M.W.H.), Rockefeller Neuroscience Institute, Department of Medicine (S.H.), and West Virginia Clinical and Translational Science Institute (S.H.), West Virginia University, Morgantown; and the Department of Neurology, Vanderbilt University, Nashville (D.O.C.)., Tirumalai P; From the Departments of Neurosurgery (A.R.R., P.-F.D., M.R.), Neuroradiology (P.-F.D., J.C., R.I.M., P.W., A.T.), Neuroscience (A.R.R., V.F., C.V.L.T., T.A., P.T., M.W.H., R.I.M.), Neurology (K.W., U.N., M.W.H.), and Behavioral Medicine and Psychiatry (M.W.H.), Rockefeller Neuroscience Institute, Department of Medicine (S.H.), and West Virginia Clinical and Translational Science Institute (S.H.), West Virginia University, Morgantown; and the Department of Neurology, Vanderbilt University, Nashville (D.O.C.)., Claassen DO; From the Departments of Neurosurgery (A.R.R., P.-F.D., M.R.), Neuroradiology (P.-F.D., J.C., R.I.M., P.W., A.T.), Neuroscience (A.R.R., V.F., C.V.L.T., T.A., P.T., M.W.H., R.I.M.), Neurology (K.W., U.N., M.W.H.), and Behavioral Medicine and Psychiatry (M.W.H.), Rockefeller Neuroscience Institute, Department of Medicine (S.H.), and West Virginia Clinical and Translational Science Institute (S.H.), West Virginia University, Morgantown; and the Department of Neurology, Vanderbilt University, Nashville (D.O.C.)., Hodder S; From the Departments of Neurosurgery (A.R.R., P.-F.D., M.R.), Neuroradiology (P.-F.D., J.C., R.I.M., P.W., A.T.), Neuroscience (A.R.R., V.F., C.V.L.T., T.A., P.T., M.W.H., R.I.M.), Neurology (K.W., U.N., M.W.H.), and Behavioral Medicine and Psychiatry (M.W.H.), Rockefeller Neuroscience Institute, Department of Medicine (S.H.), and West Virginia Clinical and Translational Science Institute (S.H.), West Virginia University, Morgantown; and the Department of Neurology, Vanderbilt University, Nashville (D.O.C.)., Haut MW; From the Departments of Neurosurgery (A.R.R., P.-F.D., M.R.), Neuroradiology (P.-F.D., J.C., R.I.M., P.W., A.T.), Neuroscience (A.R.R., V.F., C.V.L.T., T.A., P.T., M.W.H., R.I.M.), Neurology (K.W., U.N., M.W.H.), and Behavioral Medicine and Psychiatry (M.W.H.), Rockefeller Neuroscience Institute, Department of Medicine (S.H.), and West Virginia Clinical and Translational Science Institute (S.H.), West Virginia University, Morgantown; and the Department of Neurology, Vanderbilt University, Nashville (D.O.C.).

Publikováno v: The New England journal of medicine [N Engl J Med] 2024 Jan 04; Vol. 390 (1), pp. 55-62.

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Ultrasound-mediated blood-brain barrier opening uncovers an intracerebral perivenous fluid network in persons with Alzheimer's disease.

Autor: Mehta RI; Department of Neuroradiology, West Virginia University, 1 Medical Center Dr, Morgantown, WV, 26506, USA. rashi.mehta@hsc.wvu.edu.; Department of Neuroscience, West Virginia University, Morgantown, WV, 26506, USA. rashi.mehta@hsc.wvu.edu.; Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, 26506, USA. rashi.mehta@hsc.wvu.edu., Carpenter JS; Department of Neuroradiology, West Virginia University, 1 Medical Center Dr, Morgantown, WV, 26506, USA.; Department of Neuroscience, West Virginia University, Morgantown, WV, 26506, USA.; Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, 26506, USA., Mehta RI; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, 60612, USA.; Department of Pathology, Rush University Medical Center, Chicago, IL, 60612, USA., Haut MW; Department of Neuroscience, West Virginia University, Morgantown, WV, 26506, USA.; Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, 26506, USA.; Department of Behavioral Medicine and Psychiatry, West Virginia University, Morgantown, WV, 26506, USA.; Department of Neurology, West Virginia University, Morgantown, WV, 26506, USA., Wang P; Department of Neuroradiology, West Virginia University, 1 Medical Center Dr, Morgantown, WV, 26506, USA.; Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, 26506, USA., Ranjan M; Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, 26506, USA.; Department of Neurosurgery, West Virginia University, Morgantown, WV, 26506, USA., Najib U; Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, 26506, USA.; Department of Neurology, West Virginia University, Morgantown, WV, 26506, USA., D'Haese PF; Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, 26506, USA., Rezai AR; Department of Neuroscience, West Virginia University, Morgantown, WV, 26506, USA.; Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, 26506, USA.; Department of Neurosurgery, West Virginia University, Morgantown, WV, 26506, USA.

Publikováno v: Fluids and barriers of the CNS [Fluids Barriers CNS] 2023 Jun 16; Vol. 20 (1), pp. 46. Date of Electronic Publication: 2023 Jun 16.

Focused ultrasound-mediated blood-brain barrier opening in Alzheimer's disease: long-term safety, imaging, and cognitive outcomes.

Autor: Rezai AR; Departments of1Neurosurgery.; 2Neurosciences., Ranjan M; Departments of1Neurosurgery., Haut MW; 3Behavioral Medicine and Psychiatry.; 4Neurology, and., Carpenter J; 5Neuroradiology, WVU Rockefeller Neuroscience Institute, Morgantown, West Virginia., D'Haese PF; 5Neuroradiology, WVU Rockefeller Neuroscience Institute, Morgantown, West Virginia., Mehta RI; 5Neuroradiology, WVU Rockefeller Neuroscience Institute, Morgantown, West Virginia., Najib U; 4Neurology, and., Wang P; 5Neuroradiology, WVU Rockefeller Neuroscience Institute, Morgantown, West Virginia., Claassen DO; 6Department of Neurology, Vanderbilt University, Nashville, Tennessee., Chazen JL; Departments of7Radiology and., Krishna V; 8Department of Neurosurgery, University of North Carolina, Chapel Hill, North Carolina., Deib G; 5Neuroradiology, WVU Rockefeller Neuroscience Institute, Morgantown, West Virginia., Zibly Z; 9Department of Neurosurgery, Sheba Medical Center, Ramat Gan, Israel; and., Hodder SL; 10West Virginia Clinical and Translational Science Institute, West Virginia University, Morgantown, West Virginia., Wilhelmsen KC; 4Neurology, and., Finomore V; 2Neurosciences., Konrad PE; Departments of1Neurosurgery.; 2Neurosciences., Kaplitt M; 11Neurological Surgery, Weill Cornell Medical College, New York, New York.

Publikováno v: Journal of neurosurgery [J Neurosurg] 2022 Nov 04; Vol. 139 (1), pp. 275-283. Date of Electronic Publication: 2022 Nov 04 (Print Publication: 2023).

Non-invasive vagus nerve stimulation for prevention of migraine: The multicenter, randomized, double-blind, sham-controlled PREMIUM II trial.

Autor: Najib U; WVU Headache Center, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA., Smith T; StudyMetrix Research, St. Peters, MO, USA., Hindiyeh N; Stanford University Medical Center, Palo Alto, CA, USA., Saper J; Michigan Head Pain and Neurological Institute, Ann Arbor, MI, USA., Nye B; Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA., Ashina S; Beth Israel Deaconess Medical Center, Department of Neurology, Harvard Medical School, Boston, MA, USA., McClure CK; North American Science Associates, Inc., Minneapolis, MN, USA., Marmura MJ; Thomas Jefferson University, Department of Neurology, Jefferson Headache Center, Philadelphia, PA, USA., Chase S; Chase Advocate Consulting, LLC, Cocoa Beach, FL, USA., Liebler E; electroCore, Inc., Rockaway, NJ, USA., Lipton RB; Montefiore Headache Center, Bronx, NY, USA.

Publikováno v: Cephalalgia : an international journal of headache [Cephalalgia] 2022 Jun; Vol. 42 (7), pp. 560-569. Date of Electronic Publication: 2022 Jan 09.