Family-based exome-wide association study of childhood acute lymphoblastic leukemia among Hispanics confirms role of ARID5B in susceptibility.

Autor: Archer NP; University of Texas School of Public Health, Austin Regional Campus, Austin, Texas, United States of America., Perez-Andreu V; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.; Hematologic Malignancies Program, Comprehensive Cancer Center, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America., Stoltze U; University Hospital Copenhagen, Copenhagen, Denmark., Scheurer ME; Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, Texas, United States of America., Wilkinson AV; Michael & Susan Dell Center for Healthy Living, University of Texas Health Science Center at Houston, School of Public Health, Austin Regional Campus, Austin, Texas, United States of America., Lin TN; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America., Qian M; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America., Goodings C; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.; Hematologic Malignancies Program, Comprehensive Cancer Center, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America., Swartz MD; Department of Biostatistics, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America., Ranjit N; Michael & Susan Dell Center for Healthy Living, University of Texas Health Science Center at Houston, School of Public Health, Austin Regional Campus, Austin, Texas, United States of America., Rabin KR; Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, Texas, United States of America., Peckham-Gregory EC; Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, Texas, United States of America., Plon SE; Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, Texas, United States of America., de Alarcon PA; Department of Pediatrics, University of Illinois College of Medicine at Peoria, Peoria, Illinois, United States of America., Zabriskie RC; Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, Texas, United States of America., Antillon-Klussmann F; Unidad Nacional de Oncología Pediátrica, Guatemala City, Guatemala.; School of Medicine, Francisco Marroquín University, Guatemala City, Guatemala., Najera CR; Unidad Nacional de Oncología Pediátrica, Guatemala City, Guatemala., Yang JJ; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.; Hematologic Malignancies Program, Comprehensive Cancer Center, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America., Lupo PJ; Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, Texas, United States of America.

Publikováno v: PloS one [PLoS One] 2017 Aug 17; Vol. 12 (8), pp. e0180488. Date of Electronic Publication: 2017 Aug 17 (Print Publication: 2017).

NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity.

Autor: Moriyama T; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.; Department of Pediatrics, Mie University Graduate School of Medicine, Mie, Japan., Nishii R; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.; Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University Graduate School of Medicine, Tokyo, Japan., Perez-Andreu V; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Yang W; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Klussmann FA; Unidad Nacional de Oncología Pediátrica, Guatemala City, Guatemala.; Francisco Marroquin Medical School, Guatemala City, Guatemala., Zhao X; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Lin TN; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Hoshitsuki K; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.; School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Nersting J; Department of Paediatrics and Adolescent Medicine, University Hospital Rigshospitalet, Copenhagen, Denmark., Kihira K; Department of Pediatrics, Mie University Graduate School of Medicine, Mie, Japan., Hofmann U; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.; Department of Clinical Pharmacology, University Hospital Tübingen, Tübingen, Germany., Komada Y; Department of Pediatrics, Mie University Graduate School of Medicine, Mie, Japan., Kato M; Department of Pediatric Hematology and Oncology Research, National Center for Child Health and Development, Tokyo, Japan., McCorkle R; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Li L; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Koh K; Department of Hematology/Oncology, Saitama Children's Medical Center, Saitama, Japan., Najera CR; Unidad Nacional de Oncología Pediátrica, Guatemala City, Guatemala., Kham SK; National University Cancer Institute, National University Health System, Singapore., Isobe T; Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan., Chen Z; National University Cancer Institute, National University Health System, Singapore., Chiew EK; National University Cancer Institute, National University Health System, Singapore., Bhojwani D; Department of Pediatrics, Children's Hospital of Los Angeles, Los Angeles, California, USA., Jeffries C; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Lu Y; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Schwab M; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.; Department of Clinical Pharmacology, University Hospital Tübingen, Tübingen, Germany.; German Cancer Consortium, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Pharmacy and Biochemistry, University of Tübingen, Tübingen, Germany., Inaba H; Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Pui CH; Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Relling MV; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Manabe A; Department of Pediatrics, St. Luke's International Hospital, Tokyo, Japan., Hori H; Department of Pediatrics, Mie University Graduate School of Medicine, Mie, Japan., Schmiegelow K; Department of Paediatrics and Adolescent Medicine, University Hospital Rigshospitalet, Copenhagen, Denmark.; Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Yeoh AE; National University Cancer Institute, National University Health System, Singapore.; Viva University Children's Cancer Centre, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Evans WE; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Yang JJ; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

Publikováno v: Nature genetics [Nat Genet] 2016 Apr; Vol. 48 (4), pp. 367-73. Date of Electronic Publication: 2016 Feb 15.