PARP3 supervises G9a-mediated repression of adhesion and hypoxia-responsive genes in glioblastoma cells

Autor: Leonel Nguekeu-Zebaze, Najat Hanini, Aurélia Noll, Nadège Wadier, Jean-Christophe Amé, Lisa Roegel, Françoise Dantzer

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-19 (2022)

Abstract In breast cancer, Poly(ADP-ribose) polymerase 3 (PARP3) has been identified as a key driver of tumor aggressiveness exemplifying its selective inhibition as a promising surrogate for clinical activity onto difficult-to-treat cancers. Here we

Externí odkaz: https://doaj.org/article/4f7f505c7b4141a499a7ed84a569c42b

PARP3, a new therapeutic target to alter Rictor/mTORC2 signaling and tumor progression in BRCA1-associated cancers

Autor: Valérie Schreiber, Vincent Heyer, Carole Beck, Najat Hanini, Bernardo Reina San Martin, Laurent Gauthier, Mikael Elofsson, Françoise Dantzer, Agnès Tissier, José Manuel Rodríguez-Vargas, Christian Boehler, Isabelle Robert

Publikováno v: Cell Death and Differentiation
Cell Death and Differentiation, 2019, 26 (9), pp.1615-1630. ⟨10.1038/s41418-018-0233-1⟩
Cell Death and Differentiation, Nature Publishing Group, 2019, 26 (9), pp.1615-1630. ⟨10.1038/s41418-018-0233-1⟩
Cell Death Differ

PARP3 has been shown to be a key driver of TGFβ-induced epithelial-to-mesenchymal transition (EMT) and stemness in breast cancer cells, emerging as an attractive therapeutic target. Nevertheless, the therapeutic value of PARP3 inhibition has not yet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eee6a36c26f906c5471f2e71cd75ad92
https://hal.science/hal-02330194