Zobrazeno 1 - 10
of 183
pro vyhledávání: '"Najat C Daw"'
Autor:
Danh D. Truong, Salah-Eddine Lamhamedi-Cherradi, Robert W. Porter, Sandhya Krishnan, Jyothishmathi Swaminathan, Amber Gibson, Alexander J. Lazar, J. Andrew Livingston, Vidya Gopalakrishnan, Nancy Gordon, Najat C. Daw, Nicholas E. Navin, Richard Gorlick, Joseph A. Ludwig
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-16 (2023)
Abstract Background Single-cell RNA-seq has emerged as an innovative technology used to study complex tissues and characterize cell types, states, and lineages at a single-cell level. Classification of bulk tumors by their individual cellular constit
Externí odkaz:
https://doaj.org/article/482dd5ae5a4547e1b7a5b46f06fd1adc
Autor:
Hannah C. Beird, Chia-Chin Wu, Michael Nakazawa, Davis Ingram, Joseph R. Daniele, Rossana Lazcano, Latasha Little, Christopher Davies, Najat C. Daw, Khalida Wani, Wei-Lien Wang, Xingzhi Song, Curtis Gumbs, Jianhua Zhang, Brian Rubin, Anthony Conley, Adrienne M. Flanagan, Alexander J. Lazar, P. Andrew Futreal
Publikováno v:
HGG Advances, Vol 4, Iss 4, Pp 100224- (2023)
Summary: Rhabdomyosarcoma accounts for roughly 1% of adult sarcomas, with pleomorphic rhabdomyosarcoma (PRMS) as the most common subtype. Survival outcomes remain poor for patients with PRMS, and little is known about the molecular drivers of this di
Externí odkaz:
https://doaj.org/article/8f83e71f25e6448d86be6cae90b5eeb4
Autor:
Salah-Eddine Lamhamedi-Cherradi, Mayinuer Maitituoheti, Brian A. Menegaz, Sandhya Krishnan, Amelia M. Vetter, Pamela Camacho, Chia-Chin Wu, Hannah C. Beird, Robert W. Porter, Davis R. Ingram, Vandhana Ramamoorthy, Sana Mohiuddin, David McCall, Danh D. Truong, Branko Cuglievan, P. Andrew Futreal, Alejandra Ruiz Velasco, Nazanin Esmaeili Anvar, Budi Utama, Mark Titus, Alexander J. Lazar, Wei-Lien Wang, Cristian Rodriguez-Aguayo, Ravin Ratan, J. Andrew Livingston, Kunal Rai, A. Robert MacLeod, Najat C. Daw, Andrea Hayes-Jordan, Joseph A. Ludwig
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Androgen receptor can promote tumour progression in desmoplastic small round cell tumour (DSRCT), an aggressive paediatric malignancy that predominantly affects young males. Here, the authors show that DSRCT is an AR-driven malignancy and sensitive t
Externí odkaz:
https://doaj.org/article/cfcacf91444e4871813d824beaa46a7e
Autor:
Chia-Chin Wu, Hannah C. Beird, J. Andrew Livingston, Shailesh Advani, Akash Mitra, Shaolong Cao, Alexandre Reuben, Davis Ingram, Wei-Lien Wang, Zhenlin Ju, Cheuk Hong Leung, Heather Lin, Youyun Zheng, Jason Roszik, Wenyi Wang, Shreyaskumar Patel, Robert S. Benjamin, Neeta Somaiah, Anthony P. Conley, Gordon B. Mills, Patrick Hwu, Richard Gorlick, Alexander Lazar, Najat C. Daw, Valerae Lewis, P. Andrew Futreal
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
The efficacy of immune checkpoint inhibitors (ICI) in osteosarcoma has been limited. Here, the authors investigate the immunogenomic landscape of osteosarcoma, and integrated analyses highlight features related to a suppressed immune microenvironment
Externí odkaz:
https://doaj.org/article/9625ce655ae742c48c06ec6ccd628544
Autor:
Michael W. Bishop, Shailesh M. Advani, Milena Villarroel, Catherine A. Billups, Fariba Navid, Cecilia Rivera, Juan A. Quintana, Jami S. Gattuso, Pamela S. Hinds, Najat C. Daw
Publikováno v:
Journal of Global Oncology, Vol 4, Pp 1-11 (2017)
Purpose: Health-related quality of life (HRQOL) improves throughout treatment of patients with nonmetastatic osteosarcoma. We compared HRQOL for patients in the United States and Chile treated on an international trial (OS99) with polychemotherapy an
Externí odkaz:
https://doaj.org/article/858c23104cfe4a55a5acd3ffc6c7d00c
Autor:
Eric R, Molina, Letitia K, Chim, Salah-Eddine, Lamhamedi-Cherradi, Sana, Mohiuddin, David, McCall, Branko, Cuglievan, Sandhya, Krishnan, Robert W, Porter, Davis R, Ingram, Wei-Lien, Wang, Alexander J, Lazar, David W, Scott, Danh D, Truong, Najat C, Daw, Joseph A, Ludwig, Antonios G, Mikos
Publikováno v:
Oncotarget. 13:521-533
Osteosarcoma (OS) is a genetically diverse bone cancer that lacks a consistent targetable mutation. Recent studies suggest the IGF/PI3K/mTOR pathway and YAP/TAZ paralogs regulate cell fate and proliferation in response to biomechanical cues within th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42de9557008b4a4fe4f4c71efa3bc898
https://doi.org/10.18632/oncotarget.28215
https://doi.org/10.18632/oncotarget.28215
Autor:
Clinton F. Stewart, Burgess B. Freeman, Stacy L. Throm, K. Elaine Harstead, David M. Loeb, Jennifer Reikes Willert, Bhaskar Rao, Michael Neel, Victor M. Santana, Jianrong Wu, Shenghua Mao, Najat C. Daw, Fariba Navid, David C. Turner
Purpose: To describe sources of interindividual variability in bevacizumab disposition in pediatric patients and explore associations among bevacizumab pharmacokinetics and clinical wound healing outcomes.Experimental Design: Before tumor resection,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c735d08d71518fd443f7e25a1e9a5a5e
https://doi.org/10.1158/1078-0432.c.6521471.v1
https://doi.org/10.1158/1078-0432.c.6521471.v1
Autor:
Joseph A. Ludwig, Andrea Hayes-Jordan, Alexander J. Lazar, Barry W. Feig, Najat C. Daw, Cynthia E. Herzog, Shreyaskumar Patel, Robert S. Benjamin, Mary Frances McAleer, Wei Qiao, Dina C. Lev, Raphael E. Pollock, Pete M. Anderson, Vandhana Ramamoorthy, Winston Huh, Pamela Camacho, Brian A. Menegaz, Branko Cuglievan, Salah-Eddine Lamhamedi-Cherradi, Vivek Subbiah
Response for front-line chemotherapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::babce5935e0e9d877caafca9b3df2a28
https://doi.org/10.1158/1078-0432.22470341.v1
https://doi.org/10.1158/1078-0432.22470341.v1
Autor:
Eric Rohren, Homer Macapinlac, Eugenie Kleinerman, Gregory Ravizzini, Funda Meric-Bernstam, David S. Hong, Sant Chawla, Robert S. Benjamin, Joseph A. Ludwig, Neeta Somaiah, Najat C. Daw, Vinod Ravi, Winston W. Huh, Kenneth Hess, Kalevi Kairemo, Pete M. Anderson, Vivek Subbiah
Purpose:The prognosis of metastatic osteosarcoma continues to be poor. We hypothesized that alpha-emitting, bone-targeting radium 223 dichloride (223RaCl2) can be safely administered to patients with osteosarcoma and that early signals of response or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1477909917b008234b5d57157d85bed3
https://doi.org/10.1158/1078-0432.c.6528264.v1
https://doi.org/10.1158/1078-0432.c.6528264.v1
Autor:
Clinton F. Stewart, Burgess B. Freeman, Stacy L. Throm, K. Elaine Harstead, David M. Loeb, Jennifer Reikes Willert, Bhaskar Rao, Michael Neel, Victor M. Santana, Jianrong Wu, Shenghua Mao, Najat C. Daw, Fariba Navid, David C. Turner
PDF file - 200K, Supplementary Table 1. Comparison of predictive performance for model parameterizations A, (B), and C (with IBW covariate) Supplemental Figure 1. The base structural bevacizumab model consisted of a two compartment model parameterize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b2018329160909b9d070253b4a6cefe
https://doi.org/10.1158/1078-0432.22448723
https://doi.org/10.1158/1078-0432.22448723