Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Najah Abi-Gerges"'
Autor:
Václav Havel, Andrew C. Kruegel, Benjamin Bechand, Scot McIntosh, Leia Stallings, Alana Hodges, Madalee G. Wulf, Mel Nelson, Amanda Hunkele, Michael Ansonoff, John E. Pintar, Christopher Hwu, Rohini S. Ople, Najah Abi-Gerges, Saheem A. Zaidi, Vsevolod Katritch, Mu Yang, Jonathan A. Javitch, Susruta Majumdar, Scott E. Hemby, Dalibor Sames
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Ibogaine and its main metabolite noribogaine provide important molecular prototypes for markedly different treatment of substance use disorders and co-morbid mental health illnesses. However, these compounds present a cardiac safety risk and
Externí odkaz:
https://doaj.org/article/a56405d25d8040d397ce8623055b504b
Autor:
Jessica M. Miller, Moustafa H. Meki, Ahmed Elnakib, Qinghui Ou, Riham R. E. Abouleisa, Xian-Liang Tang, Abou Bakr M. Salama, Ahmad Gebreil, Cindy Lin, Hisham Abdeltawab, Fahmi Khalifa, Bradford G. Hill, Najah Abi-Gerges, Roberto Bolli, Ayman S. El-Baz, Guruprasad A. Giridharan, Tamer M. A. Mohamed
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
A physiological culture system to electro-mechanically stimulate pig heart slices to assess the drug effects on the functionality, metabolic activity, and structural integrity of the heart tissue under physiological and hypertrophic condition.
Externí odkaz:
https://doaj.org/article/8f7047372b45403fa49e32a251dab857
Autor:
Anh Tuan Ton, William Nguyen, Katrina Sweat, Yannick Miron, Eduardo Hernandez, Tiara Wong, Valentyna Geft, Andrew Macias, Ana Espinoza, Ky Truong, Lana Rasoul, Alexa Stafford, Tamara Cotta, Christina Mai, Tim Indersmitten, Guy Page, Paul E. Miller, Andre Ghetti, Najah Abi-Gerges
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Late sodium current (late INa) inhibition has been proposed to suppress the incidence of arrhythmias generated by pathological states or induced by drugs. However, the role of late INa in the human heart is still poorly understood. We theref
Externí odkaz:
https://doaj.org/article/9370b3fc5ae4452d944997c5ebf6e262
Publikováno v:
Cells, Vol 10, Iss 12, p 3370 (2021)
Subtype-specific human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are promising tools, e.g., to assess the potential of drugs to cause chronotropic effects (nodal hiPSC-CMs), atrial fibrillation (atrial hiPSC-CMs), or ventricula
Externí odkaz:
https://doaj.org/article/67feda51c88a4a5f8455d72bbae1fb09
Publikováno v:
Frontiers in Physiology, Vol 8 (2018)
To assess drug-induced pro-arrhythmic risk, especially Torsades de Pointe (TdP), new models have been proposed, such as in-silico modeling of ventricular action potential (AP) and stem cell-derived cardiomyocytes (SC-CMs). Previously we evaluated the
Externí odkaz:
https://doaj.org/article/ec8a7ab55f82419091b2e536c293fa1a
Autor:
Nathalie Nguyen, William Nguyen, Brynna Nguyenton, Phachareeya Ratchada, Guy Page, Paul E. Miller, Andre Ghetti, Najah Abi-Gerges
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
Cardiac safety remains the leading cause of drug development discontinuation. We developed a human cardiomyocyte-based model that has the potential to provide a predictive preclinical approach for simultaneously predicting drug-induced inotropic and
Externí odkaz:
https://doaj.org/article/97038ffc628241a5a180e8e55611c140
Autor:
Oliver J. Britton, Najah Abi-Gerges, Guy Page, Andre Ghetti, Paul E. Miller, Blanca Rodriguez
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
Background:In silico modeling could soon become a mainstream method of pro-arrhythmic risk assessment in drug development. However, a lack of human-specific data and appropriate modeling techniques has previously prevented quantitative comparison of
Externí odkaz:
https://doaj.org/article/f9f567a66ef045c5a3dc158a52de5b6a
Autor:
'Yann-Stanislas H.M. Barral, Liudmila Polonchuk, Gary R. Mirams, Michael Clerx, Guy Page, Katrina Sweat, Najah Abi-Gerges, Ken Wang, David J. Gavaghan\\'
Publikováno v:
Computing in Cardiology Conference (CinC).
Autor:
Andre Ghetti, Guy Page, Brian Krause, Bryce Winrow, Yannick Miron, Ky Truong, Alexa Stafford, Najah Abi Gerges
Publikováno v:
Journal of visualized experiments : JoVE. (186)
The evaluation of changes in heart contractility is essential during preclinical development for new cardiac- and non-cardiac-targeted compounds. This paper describes a protocol for assessing changes in contractility in adult human primary ventricula
Autor:
Norbert Nagy, Kaisa Syrjänen, Piet Finckenberg, Gerd Wohlfahrt, Jouko Levijoki, Tuula Koskelainen, A. Koivisto, András Varró, Paul E. Miller, László Virág, Najah Abi-Gerges, Leena Otsomaa, Eero Mervaala, Andrea Ghetti, Hugh Chapman, Saara‐Elisa Peltokorpi, Aira Heikkilä, Norbert Jost, Guy Page, Julius Gy. Papp, Zsófia Kohajda
Publikováno v:
British Journal of Pharmacology
BACKGROUND AND PURPOSE: The lack of selective sodium-calcium exchanger (NCX) inhibitors has hampered the exploration of physiological and pathophysiological roles of cardiac NCX 1.1. We aimed to discover more potent and selective drug like NCX 1.1 in