Immune checkpoint inhibitors efficacy across solid cancers and the utility of PD-L1 as a biomarker of response: a systematic review and meta-analysis

Autor: T Fitzsimmons, N Singh, TDJ Walker, C Newton, DGR Evans, EJ Crosbie, NAJ Ryan

Background: Immune checkpoint inhibitors (ICPI) are a tumour agnostic treatment. However, trials of their use have been site specific. Here we summarise the trial data and explore the utility of programmed death-ligand 1 (PD-L1) expression as a bioma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aec47d17bf1ff6c3ab6b067f115ea7bd
https://doi.org/10.21203/rs.3.rs-2493110/v1

Ischaemic bowel perforation secondary to a gravid uterus in a patient with treated inflammatory bowel disease and an ileoanal pouch: a case report

Autor: C Vickery, S Nagabushanam, M J Jones, Naj Ryan, P Burn, E Wasson, N Fazili

Publikováno v: Annals of the Royal College of Surgeons of England. 103(5)

The diagnosis of visceral perforation during pregnancy is often delayed and the management complex. A 32-year-old primigravid woman in her second trimester presented with abdominal pain and a pre-existing ileoanal pouch. Initial imaging was negative

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5f5ec028c4e8d6d3c1916995d726288
https://pubmed.ncbi.nlm.nih.gov/33930284

Biomarkers needed to predict progestin response in endometrial cancer

Autor: Naj Ryan, AE Derbyshire, Emma J Crosbie

Publikováno v: BJOG : an international journal of obstetrics and gynaecology. 124(10)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d09e533b434c40f780c91ab9d1f026f9
https://pubmed.ncbi.nlm.nih.gov/28128512

The survival benefit associated with complete macroscopic resection in epithelial ovarian cancer is histotype specific.

Autor: Porter JM; The Nicola Murray Centre for Ovarian Cancer Research, Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., McFarlane I; The Nicola Murray Centre for Ovarian Cancer Research, Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Bartos C; The Nicola Murray Centre for Ovarian Cancer Research, Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Churchman M; The Nicola Murray Centre for Ovarian Cancer Research, Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., May J; The Royal Infirmary of Edinburgh, NHS Lothian, Edinburgh, UK., Herrington CS; The Nicola Murray Centre for Ovarian Cancer Research, Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; The Royal Infirmary of Edinburgh, NHS Lothian, Edinburgh, UK., Connolly KC; Edinburgh Cancer Centre, Western General Hospital, NHS Lothian, Edinburgh, UK., Ryan NAJ; The Royal Infirmary of Edinburgh, NHS Lothian, Edinburgh, UK., Hollis RL; The Nicola Murray Centre for Ovarian Cancer Research, Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.

Publikováno v: JNCI cancer spectrum [JNCI Cancer Spectr] 2024 Jul 01; Vol. 8 (4).

Constitutional Microsatellite Instability, Genotype, and Phenotype Correlations in Constitutional Mismatch Repair Deficiency.

Autor: Gallon R; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK. Electronic address: richard.gallon@newcastle.ac.uk., Phelps R; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Hayes C; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Brugieres L; Department of Children and Adolescents Oncology, Gustave Roussy, Université Paris-Saclay, Villejuif, France., Guerrini-Rousseau L; Department of Children and Adolescents Oncology, Gustave Roussy, Université Paris-Saclay, Villejuif, France; Team 'Genomics and Oncogenesis of pediatric Brain Tumors,' INSERM U981, Gustave Roussy, Université Paris-Saclay, Villejuif, France., Colas C; Département de Génétique, Institut Curie, Paris, France; INSERM U830, Université de Paris, Paris, France., Muleris M; Sorbonne Université, Institut National de la Santé et de la Recherche Médicale, Centre de Recherche Saint-Antoine, Paris, France., Ryan NAJ; The Academic Women's Health Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK; Department of Gynaecology Oncology, Royal Infirmary of Edinburgh, Edinburgh, UK., Evans DG; Division of Evolution, Infection and Genomics, University of Manchester, Manchester, UK., Grice H; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Jessop E; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Kunzemann-Martinez A; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK; Centre for Inflammation and Tissue Repair, University College London, London, UK., Marshall L; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Schamschula E; Institute of Human Genetics, Medical University of Innsbruck, Innsbruck, Austria., Oberhuber K; Institute of Human Genetics, Medical University of Innsbruck, Innsbruck, Austria., Azizi AA; Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria., Baris Feldman H; The Genetics Institute and Genomics Center, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Beilken A; Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany., Brauer N; Pediatric Oncology, Helios-Klinikum, Krefeld, Germany., Brozou T; Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children's Hospital, Medical Faculty, Heinrich Heine University, Duesseldorf, Germany., Dahan K; Centre de Génétique Humaine, Institut de Pathologie et Génétique, Gosselies, Belgium., Demirsoy U; Department of Pediatric Oncology, Kocaeli University, Kocaeli, Turkey., Florkin B; Department of Pediatrics, Citadelle Hospital, University of Liège, Liège, Belgium., Foulkes W; Program in Cancer Genetics, Departments of Oncology and Human Genetics, McGill University, Montreal, Quebec, Canada; Department of Human Genetics, McGill University, Montreal, Quebec, Canada; Department of Medical Genetics, McGill University Health Centre, Montreal, Quebec, Canada; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada., Januszkiewicz-Lewandowska D; Department of Pediatric Oncology, Hematology and Transplantation Medical University, Poznan, Poland., Jones KJ; Department of Clinical Genetics, Western Sydney Genetics Program, Children's Hospital at Westmead, Sydney, New South Wales, Australia; University of Sydney School of Medicine, Sydney, New South Wales, Australia., Kratz CP; Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany., Lobitz S; Gemeinschaftsklinikum Mittelrhein, Department of Pediatric Hematology and Oncology, Koblenz, Germany., Meade J; Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Nathrath M; Pediatric Hematology and Oncology, Klinikum Kassel, Kassel, Germany; Department of Pediatrics, Pediatric Oncology Center, Technische Universität München, Munich, Germany., Pander HJ; Institut für Klinische Genetik, Olgahospital, Stuttgart, Germany., Perne C; Institute of Human Genetics, Medical Faculty, University of Bonn and National Center for Hereditary Tumor Syndromes, University Hospital Bonn, Bonn, Germany., Ragab I; Pediatrics Department, Hematology-Oncology Unit, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Ripperger T; Department of Human Genetics, Hannover Medical School, Hannover, Germany., Rosenbaum T; Department of Pediatrics, Sana Kliniken Duisburg, Duisburg, Germany., Rueda D; Hereditary Cancer Laboratory, University Hospital Doce de Octubre, i+12 Research Institute, Madrid, Spain., Sarosiek T; Department of Oncology, Luxmed Onkologia, Warsaw, Poland., Sehested A; Department of Pediatrics and Adolescent Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Spier I; Institute of Human Genetics, Medical Faculty, University of Bonn and National Center for Hereditary Tumor Syndromes, University Hospital Bonn, Bonn, Germany., Suerink M; Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands., Zimmermann SY; Department of Pediatric Hematology and Oncology, Children's Hospital, University Hospital, Frankfurt, Germany., Zschocke J; Institute of Human Genetics, Medical University of Innsbruck, Innsbruck, Austria., Borthwick GM; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Wimmer K; Institute of Human Genetics, Medical University of Innsbruck, Innsbruck, Austria., Burn J; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Jackson MS; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Santibanez-Koref M; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.

Publikováno v: Gastroenterology [Gastroenterology] 2023 Apr; Vol. 164 (4), pp. 579-592.e8. Date of Electronic Publication: 2022 Dec 29.