1,2-Dihydroxyxanthone: Effect on A375-C5 Melanoma Cell Growth Associated with Interference with THP-1 Human Macrophage Activity

Autor: Viviana Silva, Fátima Cerqueira, Nair Nazareth, Rui Medeiros, Amélia Sarmento, Emília Sousa, Madalena Pinto

Publikováno v: Pharmaceuticals, Vol 12, Iss 2, p 85 (2019)

Xanthones have been suggested as prospective candidates for cancer treatment. 1,2- dihydroxyxanthone (1,2-DHX) is known to interfere with the growth of several cancer cell lines. We investigated the effects of 1,2-DHX on the growth of the A375-C5 mel

Externí odkaz: https://doaj.org/article/7b7c60f54d4d465c86a7bc06556f16b5

Cytotoxicity and Inhibition of Lymphocyte Proliferation of Fasciculatin, a Linear Furanosesterterpene Isolated from Ircinia variabilis Collected from the Atlantic Coast of Morocco

Autor: Werner Herz, Maria São José Nascimento, Nair Nazareth, Anake Kijjoa, Paulo M. Pinho, Aziz Fassouane, Saida Rifai

Publikováno v: Marine Drugs, Vol 3, Iss 1, Pp 15-21 (2005)

Abstract: Fasciculatin, a furanosesterterpene isolated from the marine sponge Ircinia variabilis from the Atlantic Coast of Morocco, has been evaluated for its influence on a mitogen-induced proliferation of human lymphocytes and growth of human tumo

Externí odkaz: https://doaj.org/article/362cd6812ca94bdfadfc4c20c48075a6

Mutant p53 reactivator SLMP53-2 hinders ultraviolet B radiation-induced skin carcinogenesis

Autor: Joana B. Loureiro, Rita Ribeiro, Nair Nazareth, Tiago Ferreira, Elizabeth A. Lopes, Adelina Gama, Miguel Machuqueiro, Marco G. Alves, Laura Marabini, Paula A. Oliveira, Maria M.M. Santos, Lucília Saraiva

Publikováno v: Pharmacological research. 175

The growing incidence of skin cancer (SC) has prompted the search for additional preventive strategies to counteract this global health concern. Mutant p53 (mutp53), particularly with ultraviolet radiation (UVR) signature, has emerged as a promising

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95a067442c592393410b58aef304fa48
https://pubmed.ncbi.nlm.nih.gov/34890775

Improving colon cancer therapy with a new promising small-molecule activator of the p53-pathway through disruption of p53-MDM2/MDMX interactions

Autor: Joana Soares, Lucília Saraiva, Joana A. Loureiro, Joana Almeida, Maria M. M. Santos, Margarida Espadinha, Liliana Raimundo, Marco G. Alves, Nair Nazareth, Juliana Calheiros

Publikováno v: Proceedings of 5th International Electronic Conference on Medicinal Chemistry.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::845484b1e2cd01adbcd7f4318587eb50
https://doi.org/10.3390/ecmc2019-06306

SLMP53-2 Restores Wild-Type-Like Function to Mutant p53 through Hsp70: Promising Activity in Hepatocellular Carcinoma

Autor: Alessandra Bisio, Bartolomeo Bosco, Helena Ramos, Flávio Reis, Carla Cristina Marques de Oliveira, Alberto Inga, Maria Inês Almeida, Célia Gomes, Silvano Piazza, Maria M. M. Santos, Lucília Domingues, Lucília Saraiva, Liliana Raimundo, Matthias R. Bauer, Alan R. Fersht, Sara Gomes, Joana Soares, Nair Nazareth, Joao Paulo Bras, Joana B. Loureiro, Valentina Barcherini

Publikováno v: Cancers, Vol 11, Iss 8, p 1151 (2019)
Cancers
Cancers; Volume 11; Issue 8; Pages: 1151
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Half of human cancers harbor TP53 mutations that render p53 inactive as a tumor suppressor. In these cancers, reactivation of mutant p53 (mutp53) through restoration of wild-type-like function constitutes a valuable anticancer therapeutic strategy. I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f626b299d559bf9758b3526b8e51f452
https://www.mdpi.com/2072-6694/11/8/1151