Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Naima Endesh"'
Autor:
Vincenza Caolo, Marjolaine Debant, Naima Endesh, T Simon Futers, Laeticia Lichtenstein, Fiona Bartoli, Gregory Parsonage, Elizabeth AV Jones, David J Beech
Publikováno v:
eLife, Vol 9 (2020)
Mechanical force is a determinant of Notch signalling but the mechanism of force detection and its coupling to Notch are unclear. We propose a role for Piezo1 channels, which are mechanically-activated non-selective cation channels. In cultured micro
Externí odkaz:
https://doaj.org/article/7090cc8a18db409dbe9d55c0618c0087
Autor:
Baptiste Rode, Jian Shi, Naima Endesh, Mark J. Drinkhill, Peter J. Webster, Sabine J. Lotteau, Marc A. Bailey, Nadira Y. Yuldasheva, Melanie J. Ludlow, Richard M. Cubbon, Jing Li, T. Simon Futers, Lara Morley, Hannah J. Gaunt, Katarzyna Marszalek, Hema Viswambharan, Kevin Cuthbertson, Paul D. Baxter, Richard Foster, Piruthivi Sukumar, Andrew Weightman, Sarah C. Calaghan, Stephen B. Wheatcroft, Mark T. Kearney, David J. Beech
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
The mechanisms that regulate the body’s response to exercise are poorly understood. Here, Rode et al. show that the mechanically activated cation channel Piezo1 is a molecular sensor of physical exercise in the endothelium that triggers endothelial
Externí odkaz:
https://doaj.org/article/7f62f67aa840473d94edc1b8db9c890a
Autor:
Gregory Parsonage, Kevin Cuthbertson, Naima Endesh, Nicoletta Murciano, Adam J. Hyman, Charlotte H. Revill, Oleksandr V. Povstyan, Eulashini Chuntharpursat‐Bon, Marjolaine Debant, Melanie J. Ludlow, Timothy Simon Futers, Laeticia Lichtenstein, Jacob A. Kinsella, Fiona Bartoli, Maria Giustina Rotordam, Nadine Becker, Andrea Brüggemann, Richard Foster, David J. Beech
Publikováno v:
British Journal of Pharmacology.
PIEZO1 forms mechanically activated calcium-permeable non-selective cation channels in numerous species and cell types. Options for pharmacological modulation are limited and so we modified a PIEZO1 small-molecule agonist (Yoda1) to advance capabilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ea43234b6175087acf6ca2bf966f38c
https://doi.org/10.1111/bph.15996
https://doi.org/10.1111/bph.15996
Autor:
Karen E Hemmings, Natalie J Haywood, Katherine I Bridge, Andrew Walker, Hema Viswambharan, Katie J. Simmons, Richard M Cubbon, Karen E. Porter, Ajay M. Shah, Jane Brown, David J. Beech, Emily R. Clark, Natallia Makava, Mark T. Kearney, Yilizila Abudushalamu, Khalid M. Naseem, Stephen B. Wheatcroft, Helen Imrie, Anna Skromna, V Kate Gatenby, Naima Endesh, Nadira Yuldasheva, Piruthivi Sukumar, T. Simon Futers, Paul A. Cordell
Publikováno v:
Circulation Research
Supplemental Digital Content is available in the text.
Rationale: A hallmark of type 2 diabetes is insulin resistance, which leads to increased endothelial cell (EC) production of superoxide and a simultaneous reduction in the availability of th
Rationale: A hallmark of type 2 diabetes is insulin resistance, which leads to increased endothelial cell (EC) production of superoxide and a simultaneous reduction in the availability of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9060219ad1bcabd2b1ca0baba0d5a0bb
https://eprints.whiterose.ac.uk/177316/16/CIRCRESAHA.121.319517.pdf
https://eprints.whiterose.ac.uk/177316/16/CIRCRESAHA.121.319517.pdf
Autor:
Laeticia Lichtenstein, Naima Endesh, T. Simon Futers, Vincenza Caolo, David J. Beech, Fiona Bartoli, Marjolaine Debant, Gregory Parsonage, Elizabeth A. V. Jones
Publikováno v:
eLife, Vol 9 (2020)
Elife, 9:50684. eLife Sciences Publications, Ltd
eLife
Elife, 9:50684. eLife Sciences Publications, Ltd
eLife
Mechanical force is a determinant of Notch signalling but the mechanism of force detection and its coupling to Notch are unclear. We propose a role for Piezo1 channels, which are mechanically-activated non-selective cation channels. In cultured micro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2224776928cbcc75f8f59621768c35ee
https://doi.org/10.7554/elife.50684
https://doi.org/10.7554/elife.50684
Autor:
T. Simon Futers, Laeticia Lichtenstein, Marjolaine Debant, David J. Beech, Naima Endesh, Gregory Parsonage, Elizabeth A. V. Jones, Vincenza Caolo, Fiona Bartoli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::398c8244117ac650f2e37f9a499adb88
https://doi.org/10.7554/elife.50684.sa2
https://doi.org/10.7554/elife.50684.sa2
Autor:
Vincenza Caolo, David J. Beech, Simon Futers, Laeticia Lichtenstein, Marjolaine Debant, Elizabeth A. V. Jones, Naima Endesh, Gregory Parsonage
Mechanical force has emerged as a determinant of Notch signalling but the mechanisms of force sensing and coupling to Notch are unclear. Here we propose a role for Piezo1 channels, the recently identified mechanosensors of mammalian systems. Piezo1 c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66b4286f1329c18aa96da417685c9e3e