Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Naim Nazef"'
Autor:
Jason D. Katz, Bart Lutterbach, Harold Hatch, Robert J. Mathvink, Wenxian Wang, Xianlu Qu, Kaiko Kunii, C. Gary Marshall, Bo-Sheng Pan, Keith W. Rickert, Craig Rosenstein, Alexander A. Szewczak, Jonathan R. Young, Kevin J. Lumb, David Joseph Guerin, Sangita B. Patel, Gaozhen Hang, Qinwen Zeng, Sujal V. Deshmukh, Deborah Walker, Danielle Falcone, Stephen M. Soisson, Lenora Davis, Rachael Holmes, Kerrie Spencer, William K. Dahlberg, Wei Lu, James P. Jewell, Ana Esther Ortega Gabarda, Naim Nazef, Michael D. Altman, Christopher J. Dinsmore, John F. Reilly, Jongwon Lim
Publikováno v:
Journal of Medicinal Chemistry. 54:4092-4108
c-Met is a transmembrane tyrosine kinase that mediates activation of several signaling pathways implicated in aggressive cancer phenotypes. In recent years, research into this area has highlighted c-Met as an attractive cancer drug target, triggering
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15bb91af3692bfd588518c6f2783785f
https://doi.org/10.1021/jm200112k
https://doi.org/10.1021/jm200112k
Autor:
Naim Nazef, Cliff C. Cheng, D. Allen Annis, Cheng-Chi Chuang, John D. McCarter, Huw M. Nash, Gerald W. Shipps, Todd Rowe, Robert J.M. Kurzeja
Publikováno v:
Combinatorial Chemistry & High Throughput Screening. 12:760-771
This manuscript describes the discovery and characterization of inhibitors of the lipid phosphatase SHIP2, an important target for the treatment of Type 2 diabetes, using the Automated Ligand Identification System. ALIS is an affinity selection-mass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d151261fb2420ad78b5420bc1e802cd1
https://doi.org/10.2174/138620709789104870
https://doi.org/10.2174/138620709789104870
Publikováno v:
Mass Spectrometry in Medicinal Chemistry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63f84f0f056f6df729f8efa69d48e59f
https://doi.org/10.1002/9783527610907.ch3
https://doi.org/10.1002/9783527610907.ch3
Publikováno v:
Journal of the American Chemical Society. 126:15495-15503
To realize the full potential of combinatorial chemistry-based drug discovery, generic and efficient tools must be developed that apply the strengths of diversity-oriented chemical synthesis to the identification and optimization of lead compounds fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae9013eb78b1b8388f9493585457f69f
https://doi.org/10.1021/ja048365x
https://doi.org/10.1021/ja048365x
This chapter describes the synthesis of two related sesquiterpenes, anislactone A and merrilactone A. We initially accessed a tetracyclic oxetane in the merrilactone series using a Paterno–Buchi reaction but found the compound to be too underfuncti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::274625c49170bd80316e1dc8779c9b0f
https://doi.org/10.1016/b978-0-08-099362-1.00004-7
https://doi.org/10.1016/b978-0-08-099362-1.00004-7
Autor:
Jonathan C. Cruz, Nicole Ozerova, Richard E. Middleton, Joey L. Methot, Sujal V. Deshmukh, Christopher Hamblett, Andreas Harsch, Anna M. Hitz, Judith C. Fleming, Naim Nazef, Bethany Hughes, Melissa Chenard, Astrid M. Kral, David L. Sloman, Thomas A. Miller, William K. Dahlberg, J. Paul Secrist, Matthew G. Stanton, Ralph T. Mosley, Hongmei Wang, Dawn M. Mampreian, Alex A. Szewczak
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(19)
This communication highlights the development of a nicotinamide series of histone deacetylase inhibitors within the benzamide structural class. Extensive exploration around the nicotinamide core led to the discovery of a class I selective HDAC inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aa399415c2ed87e3206d1c0265918a5
https://pubmed.ncbi.nlm.nih.gov/17761416
https://pubmed.ncbi.nlm.nih.gov/17761416
Autor:
Cliff C. Cheng, Charles E. Whitehurst, Yongmin Hou, Gerald W. Shipps, Zhiping Yao, Peter Spacciapoli, Michael Ziebell, David Lau, D. Allen Annis, Denise M. Murphy, Naim Nazef, Jason S. Felsch, Huw M. Nash
Publikováno v:
Journal of biomolecular screening. 11(2)
Screening assays using target-based affinity selection coupled with high-sensitivity detection technologies to identify small-molecule hits from chemical libraries can provide a useful discovery approach that complements traditional assay systems. Af
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e499b7b30d0bee2d84a8a67d2da4697
https://pubmed.ncbi.nlm.nih.gov/16490772
https://pubmed.ncbi.nlm.nih.gov/16490772