Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Naila Chughtai"'
Autor:
Paola Blanchette, Yiwang Zhou, Anne-Claude Gingras, Morag Park, Naila Chughtai, Tina Gruosso, Jennifer F. Knight, Sidong Huang, Andreas I. Papadakis, Philip E. Branton, Melissa Z. Mui
Publikováno v:
Journal of Virology. 89:8855-8870
When expressed alone at high levels, the human adenovirus E4orf4 protein exhibits tumor cell-specific p53-independent toxicity. A major E4orf4 target is the B55 class of PP2A regulatory subunits, and we have shown recently that binding of E4orf4 inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e694e8e6fa91dfac42061dcb3517db9
https://doi.org/10.1128/jvi.03710-14
https://doi.org/10.1128/jvi.03710-14
Autor:
Naila Chughtai, Morag Park, Serhiy Havrylov, Charles V. Rajadurai, Veena Sangwan, Bruce H. Huang, Kossay Zaoui, Frank B. Gertler, Anie Monast, Peter M. Siegel, Colin D.H. Ratcliffe, Paula P. Coelho
Publikováno v:
Rockefeller University Press
The Journal of Cell Biology
The Journal of Cell Biology
Invadopodia are membrane protrusions used by cancer cells to remodel and invade the extracellular matrix. Here, Rajadurai et al. show that the lipid phosphatase SHIP2 recruits the Ena/VASP-family actin regulatory protein Mena to stabilize invadopodia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fed06d9a4f7e39ec2a44ae836069549b
https://orcid.org/0000-0003-3214-4554
https://orcid.org/0000-0003-3214-4554
Autor:
Jean-Jacques Lebrun, Naila Chughtai, Strachan Hartley, Eftihia Cocolakis, Zaynab Nouhi, Suhad Ali
Publikováno v:
Cancer Research. 66:1824-1832
Prolactin hormone (PRL) is well characterized as a terminal differentiation factor for mammary epithelial cells and as an autocrine growth/survival factor in breast cancer cells. However, this function of PRL may not fully signify its role in breast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::011523df8bbee636fe2e254123cd3d6d
https://doi.org/10.1158/0008-5472.can-05-2292
https://doi.org/10.1158/0008-5472.can-05-2292
Autor:
Naila Chughtai, Manuela Campiglio, Matthias Stein-Gerlach, Parham Minoo, Suhad Ali, Axel Ullrich, Jean Jacques Lebrun
Publikováno v:
Cellular Signalling. 15:319-326
SHP-2, a cytosolic protein tyrosine phosphatase with two SH2 domains and multiple tyrosine phosphorylation sites, contributes to signal transduction as an enzyme and/or adaptor molecule. Here we demonstrate that prolactin (PRL) stimulation of the PRL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5ca6133504dcf1c09c3aae386ce9f7c
https://doi.org/10.1016/s0898-6568(02)00122-5
https://doi.org/10.1016/s0898-6568(02)00122-5
Publikováno v:
Journal of Biological Chemistry. 277:31107-31114
The Src homology 2 (SH2) domain containing protein-tyrosine phosphatase SHP-2 contributes to prolactin receptor (PRLR) signal transduction to beta-casein gene promoter activation. We report for the first time that SHP-2 physically associates with the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de4edfc56ac2228a3a83b598062650bf
https://doi.org/10.1074/jbc.m200156200
https://doi.org/10.1074/jbc.m200156200
Autor:
Dongmei Zuo, Ryan R. Davis, Robert D. Cardiff, Michael Hallett, Monica A. Naujokas, Jeffrey P. Gregg, Morag Park, Jason I. Herschkowitz, Naila Chughtai, Jennifer F. Knight, Anna Marie Mulligan, William J. Muller, Sadiq M. Saleh, Dushanthi Pinnaduwage, Robert Lesurf, Irene L. Andrulis, Hong Zhao, Aleix Prat
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 110(14)
Triple-negative breast cancer (TNBC) accounts for ∼20% of cases and contributes to basal and claudin-low molecular subclasses of the disease. TNBCs have poor prognosis, display frequent mutations in tumor suppressor gene p53 (TP53), and lack target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0360a5fd2a93e21664fe8b9163bdcf6d
https://pubmed.ncbi.nlm.nih.gov/23509284
https://pubmed.ncbi.nlm.nih.gov/23509284
Autor:
Marisa G. Ponzo, Frances P. O'Malley, Michael Hallett, Margarita Souleimanova, Naila Chughtai, Atilla Omeroglu, Shelley B. Bull, Robert D. Cardiff, Irene L. Andrulis, Stephanie Petkiewicz, Robert Lesurf, Dushanthi Pinnaduwage, David Germain, Morag Park, Dongmei Zuo
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 106(31)
Elevated MET receptor tyrosine kinase correlates with poor outcome in breast cancer, yet the reasons for this are poorly understood. We thus generated a transgenic mouse model targeting expression of an oncogenic Met receptor (Met mt ) to the mammary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e62b59f88bdb8a20d2ffc646cc97fe0f
https://pubmed.ncbi.nlm.nih.gov/19617568
https://pubmed.ncbi.nlm.nih.gov/19617568
Publikováno v:
The Journal of biological chemistry. 278(52)
The protein tyrosine phosphatase SHP-2 is an important regulator of the Janus kinase-2 (Jak2)/signal transducer and activator of transcription (Stat) pathway downstream of the cytokine/prolactin receptor family. We report that SHP-2 dephosphorylates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c721b469ff4d7c61cca7f13ca999b474
https://pubmed.ncbi.nlm.nih.gov/14522994
https://pubmed.ncbi.nlm.nih.gov/14522994
Autor:
Crista Thompson, Naila Chughtai, Andrea Z. Lai, Hong Zhao, Morag Park, Sean Cory, Michael Hallett
Publikováno v:
Cancer Research. 73:967-967
Signaling by the Met, hepatocyte growth factor (HGF) receptor tyrosine kinase (RTK) activates multiple downstream signaling pathways that promote cell migration and invasive growth. Cells that overexpress and are “addicted” to Met also require Me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::128c1da0a26291458fc62c0081ac1c72
https://doi.org/10.1158/1538-7445.am2013-967
https://doi.org/10.1158/1538-7445.am2013-967