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Akademický článek

Identification of CircRNA Complexes Acting on miRNA Sponges within the Exosome in Patients with Alzheimer’s Disease: An In Silico Approach

Autor: Rabia KALKAN CAKMAK, Nail BESLI, Bahar SARIKAMIS JOHNSON, Nilufer ERCIN, Hayati Sencer POLAT, Ulkan KILIC

Publikováno v: Bezmiâlem Science, Vol 12, Iss 4, Pp 413-420 (2024)

Objective: Alzheimer’s disease (AD) is a neurodegenerative ailment that launches insidiously and progresses slowly, and its prevalence gradually increases with age. In a former study, we explored the plasma exosomal circular RNA (circRNA)-micro RNA

Externí odkaz: https://doaj.org/article/72a2b6582f764813abb28e7483ddb6bb

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Akademický článek

Exosomal Circular Ribonucleic Acid–Microribonucleic Acid Expression Profile from Plasma in Alzheimer’s Disease Patients by Bioinformatics and Integrative Analysis

Autor: Nail Besli, Bahar Sarikamis, Rabia Kalkan Cakmak, Ulkan Kilic

Publikováno v: Eurasian Journal of Medicine, Vol 55, Iss 3, Pp 218-227 (2023)

Externí odkaz: https://doaj.org/article/a1b5b5a6724f4408b7947f45d853c0f1

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Akademický článek

Assessment of the Interaction of Aggregatin Protein with Amyloid-Beta (Aβ) at the Molecular Level via In Silico Analysis

Autor: Nail Besli, Guven Yenmis

Publikováno v: Acta Chimica Slovenica, Vol 67, Iss 4, Pp 1262-1272 (2020)

Alzheimer's disease is a major neurodegenerative illness whose prevalence is increasing worldwide but the molecular mechanism remains unclear. There is some scientific evidence that the molecular complexity of Alzheimer's pathophysiology is associate

Externí odkaz: https://doaj.org/article/612e0918eef34d7788531b488ae9d054

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Exosomal circRNA-miRNA Expression profile from plasma in Alzheimer’s Disease Patients by Bioinformatics and Integrative Analysis

Autor: Nail Besli, Bahar Sarikamis, Rabia Kalkan Cakmak, Ulkan Kilic

Background Alzheimer's disease (AD) is an age-dependent neurodegenerative ailment globally. Compelling evidence suggests the function of exosomal non-coding RNAs has been associated with the progression of AD but whose exosomal-linked non-coding RNAs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bb6dc881b0491fc16ee57c9081a16f3
https://doi.org/10.21203/rs.3.rs-1748115/v1

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Anti-cancer effect of metformin on the metastasis and invasion of primary breast cancer cells through mediating NF-kB activity

Autor: Ercument Ovali, Guven Yenmis, Derya Dilek Kancagi, Nail Besli, Matem Tunçdemir, Elif Yaprak Sarac, Cihan Tastan, Onur Olgac Karagulle, Turgut Ulutin, Kazım Şenol, Tugba Soydas, Muhammet Yilanci, Cumhur Gokhan Ekmekci, Gonul Kanigur Sultuybek

Current evidence strongly suggests that aberrant activation of the nuclear factor kappa B (NF-kB) signaling cascade is connected to carcinogenesis. The matrix metalloproteinases (MMP) which are also the key agents for tumor metastasis may be potent c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e441651113a1e7fc6905cb3867c687f4
https://hdl.handle.net/20.500.12445/2499

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Metformin promotes apoptosis in primary breast cancer cells by downregulation of cyclin D1 and upregulation of P53 through an AMPK-alpha independent mechanism

Autor: Kazım Şenol, Elif Yaprak Sarac, Nail Besli, Guven Yenmis, Gonul Kanigur Sultuybek, Fatma Sinem Hocaoğlu Emre

Publikováno v: Turkish Journal of Medical Sciences

Background/aim: In the present study we aimed to figure out the effect of metformin on the expression of AMPK-alpha, cyclin D1, and Tp53, and apoptosis in primary breast cancer cells (PBCCs). Materials and methods: PBCCs were treated with two doses o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::287bcb8f7b1508dc3cc0093944ced5cf
https://hdl.handle.net/20.500.12445/2202

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Assessment of the interaction of aggregatin protein with amyloid-beta (Aβ) at the molecular level via in silico analysis

Autor: Guven Yenmis, Nail Besli

Publikováno v: Acta Chimica Slovenica, Vol 67, Iss 4, Pp 1262-1272 (2020)

Alzheimer’s disease is a major neurodegenerative illness whose prevalence is increasing worldwide but the molecular mechanism remains unclear. There is some scientific evidence that the molecular complexity of Alzheimer’s pathophysiology is assoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d441c456748a2f5ad92a0e056886307
https://hdl.handle.net/20.500.12445/1814

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Metformin suppresses the proliferation and invasion through NF-kB and MMPs in MCF-7 cell line

Autor: Sibel Dogan, Nail Besli, Elif Yaprak Sarac, Seyhun Solakoglu, Guven Yenmis, Matem Tunçdemir, Gonul Kanigur Sultuybek

Objective MCF-7 cells, a breast cancer cell line, are used for experiments of estrogen receptor (ER)-positive breast cancer and many sub-clones representing different classes of ER-positive tumors. We aimed to determine the efficacy of metformin, a p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::400f19b076aa7db6429a8710c7f2a61a
https://hdl.handle.net/20.500.12445/1338

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Akademický článek

Assessment of Interaction of Human OCT 1-3 Proteins and Metformin using Silico Analyses

Autor: Faruk Berat Akçeşme, Nail Beşli, Jorge Peña-García, Horacio Pérez-Sánchez

Publikováno v: Acta Chimica Slovenica, Vol 67, Iss 4, Pp 1202-1215 (2020)

Metformin, a drug frequently used by diabetic patients as the first-line treatment worldwide, is positively charged and is transported into the cell through human organic cation transporter (hOCT 1-3) proteins. We aimed to mimic the cellular uptake o

Externí odkaz: https://doaj.org/article/89a15af7f6d044dca01997085a24232d

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