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Akademický článek

Functional epitopes and neutralizing antibodies of vaccinia virus

Autor: Fenghao Peng, Naijing Hu, Yingjun Liu, Cong Xing, Longlong Luo, Xinying Li, Jing Wang, Guojiang Chen, He Xiao, Chenghua Liu, Beifen Shen, Jiannan Feng, Chunxia Qiao

Publikováno v: Frontiers in Microbiology, Vol 14 (2023)

Smallpox is an infectious disease caused by the variola virus, and it has a high mortality rate. Historically it has broken out in many countries and it was a great threat to human health. Smallpox was declared eradicated in 1980, and Many countries

Externí odkaz: https://doaj.org/article/07b185b063c5457996a003f807ee740c

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Akademický článek

CRIC-seq protocol for in situ profiling of proximal RNA-RNA contacts associated with RNA-binding proteins

Autor: Rong Ye, Naijing Hu, Yuanchao Xue

Publikováno v: STAR Protocols, Vol 4, Iss 3, Pp 102401- (2023)

Summary: RNA-binding proteins (RBPs) can bind and mediate RNA-RNA contacts. However, identifying specific RBP-organized RNA-RNA contacts remains challenging. Here, we present a capture RIC-seq (CRIC-seq) technique to map specific RBP-associated RNA-R

Externí odkaz: https://doaj.org/article/2b5dbd3f77ef47aca5ba5bf0b8d9049a

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Akademický článek

High-affinity decoy protein, nFD164, with an inactive Fc region as a potential therapeutic drug targeting CD47

Autor: Zhihong Wang, Naijing Hu, Haitao Wang, Yuanyu Wu, Guiqi Quan, Yahui Wu, Xinying Li, Jiannan Feng, Longlong Luo

Publikováno v: Biomedicine & Pharmacotherapy, Vol 162, Iss , Pp 114618- (2023)

CD47, as an innate immune checkpoint molecule, is an important target of cancer immunotherapy. We previously reported that a high-affinity SIRPα variant FD164 fused with IgG1 subtype Fc showed a better antitumor effect than wild-type SIRPα in an im

Externí odkaz: https://doaj.org/article/f83a1c260d4f40b2bdd95ca40d80c73b

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Akademický článek

Structure-guided affinity maturation of a novel human antibody targeting the SARS-CoV-2 nucleocapsid protein

Autor: Zhihong Wang, Naijing Hu, Yangyihua Zhou, Ning Shi, Beifen Shen, Longlong Luo, Jiannan Feng

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)

Abstract The continuous mutation of SARS-CoV-2 has presented enormous challenges to global pandemic prevention and control. Recent studies have shown evidence that the genome sequence of SARS-CoV-2 nucleocapsid proteins is relatively conserved, and t

Externí odkaz: https://doaj.org/article/bb615d0c31584898b40abdd2342883c8

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Akademický článek

High-Affinity Decoy PD-1 Mutant Screened from an Epitope-Specific Cell Library

Autor: Hao Liu, Chunxia Qiao, Naijing Hu, Zhihong Wang, Jing Wang, Jiannan Feng, Beifen Shen, Yuanfang Ma, Longlong Luo

Publikováno v: Engineering, Vol 7, Iss 11, Pp 1557-1565 (2021)

Immunotherapy with anti-programmed cell death protein-1 (PD-1)/programmed cell death ligand-1 (PD-L1) monoclonal antibodies has become routine in the treatment of many kinds of human cancers, such as lung cancer, intestinal cancer, and melanoma. The

Externí odkaz: https://doaj.org/article/b25248d9110d4919acbac2b0f7e04cde

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Akademický článek

The architecture of the SARS-CoV-2 RNA genome inside virion

Autor: Changchang Cao, Zhaokui Cai, Xia Xiao, Jian Rao, Juan Chen, Naijing Hu, Minnan Yang, Xiaorui Xing, Yongle Wang, Manman Li, Bing Zhou, Xiangxi Wang, Jianwei Wang, Yuanchao Xue

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

Secondary structures and long-range RNA interactions of the SARS-CoV-2 genome have been investigated by various sequencing methods. Here the authors use an RNA-RNA hybrid sequencing method to predict the secondary and tertiary structure of the SRAS-C

Externí odkaz: https://doaj.org/article/9e50f430b49c49a7bdba77035d1bc6ef

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