Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Naig Le Guern"'
Autor:
Maxime Nguyen, Abderrahmane Bourredjem, Lionel Piroth, Bélaïd Bouhemad, Antoine Jalil, Gaetan Pallot, Naig Le Guern, Charles Thomas, Thomas Pilot, Victoria Bergas, Hélène Choubley, Jean-Pierre Quenot, Pierre-Emmanuel Charles, Laurent Lagrost, Valerie Deckert, Jean-Paul Pais de Barros, Pierre-Grégoire Guinot, David Masson, Christine Binquet, Thomas Gautier, Mathieu Blot, Lymphonie study group
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract COVID-19 pneumonia has specific features and outcomes that suggests a unique immunopathogenesis. Severe forms of COVID-19 appear to be more frequent in obese patients, but an association with metabolic disorders is not established. Here, we
Externí odkaz:
https://doaj.org/article/97f18805af9645668ad7756794ccc87c
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5333 (2023)
The gastrointestinal tract constitutes a large interface with the inner body and is a crucial barrier against gut microbiota and other pathogens. As soon as this barrier is damaged, pathogen-associated molecular patterns (PAMPs) are recognized by imm
Externí odkaz:
https://doaj.org/article/4674c7e6bf2546d39261728a3d2d5cea
Autor:
Lorène J. Lebrun, Gaëtan Pallot, Maxime Nguyen, Annabelle Tavernier, Alois Dusuel, Thomas Pilot, Valérie Deckert, Isabelle Dugail, Naig Le Guern, Jean-Paul Pais De Barros, Anissa Benkhaled, Hélène Choubley, Laurent Lagrost, David Masson, Thomas Gautier, Jacques Grober
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 13226 (2022)
Bacterial lipopolysaccharides (LPS, endotoxins) are found in high amounts in the gut lumen. LPS can cross the gut barrier and pass into the blood (endotoxemia), leading to low-grade inflammation, a common scheme in metabolic diseases. Phospholipid tr
Externí odkaz:
https://doaj.org/article/0f8c93335b114e0c98ec0c9e91652491
Autor:
Maxime Nguyen, Gaëtan Pallot, Antoine Jalil, Annabelle Tavernier, Aloïs Dusuel, Naig Le Guern, Laurent Lagrost, Jean-Paul Pais de Barros, Hélène Choubley, Victoria Bergas, Pierre-Grégoire Guinot, David Masson, Belaid Bouhemad, Thomas Gautier
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
IntroductionDuring peritonitis, lipopolysaccharides (LPS) cross the peritoneum and pass through the liver before reaching the central compartment. The aim of the present study was to investigate the role of lipoproteins and phospholipid transfer prot
Externí odkaz:
https://doaj.org/article/00d3c73725f8440f8c39f3fb958c5b01
Autor:
Aloïs Dusuel, Valérie Deckert, Jean-Paul Pais de Barros, Kevin van Dongen, Hélène Choubley, Émilie Charron, Naig Le Guern, Jérôme Labbé, Stéphane Mandard, Jacques Grober, Laurent Lagrost, Thomas Gautier
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100011- (2021)
Bacterial lipopolysaccharides (LPSs or endotoxins) can bind most proteins of the lipid transfer/LPS-binding protein (LT/LBP) family in host organisms. The LPS-bound LT/LBP proteins then trigger either an LPS-induced proinflammatory cascade or LPS bin
Externí odkaz:
https://doaj.org/article/44bb1260f336492c90708a2cd50fdd02
Autor:
Thibaut Bourgeois, Antoine Jalil, Charles Thomas, Charlène Magnani, Naig Le Guern, Thomas Gautier, Jean-Paul Pais de Barros, Victoria Bergas, Hélène Choubley, Loïc Mazzeo, Louise Menegaut, Lorène Josiane Lebrun, Kévin Van Dongen, Marion Xolin, Tony Jourdan, Chloé Buch, Jérome Labbé, Philippe Saas, Laurent Lagrost, David Masson, Jacques Grober
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100013- (2021)
Recent studies have highlighted an important role for lysophosphatidylcholine acyltransferase 3 (LPCAT3) in controlling the PUFA composition of cell membranes in the liver and intestine. In these organs, LPCAT3 critically supports cell-membrane-assoc
Externí odkaz:
https://doaj.org/article/83c4b2a37855418097b19c9a61a1428a
Autor:
Véronique Perrier, Thibaud Imberdis, Pierre-André Lafon, Marina Cefis, Yunyun Wang, Elisabeth Huetter, Jacques-Damien Arnaud, Teresa Alvarez-Martinez, Naig Le Guern, Guillaume Maquart, Laurent Lagrost, Catherine Desrumaux
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 10, Pp 1950-1961 (2017)
Transmissible spongiform encephalopathies are fatal neurodegenerative diseases with an urgent need for therapeutic and prophylactic strategies. At the time when the blood-mediated transmission of prions was demonstrated, in vitro studies indicated a
Externí odkaz:
https://doaj.org/article/05211b28be53494d859832776fc69a2e
Autor:
Lorène J. Lebrun, Kaatje Lenaerts, Dorien Kiers, Jean-Paul Pais de Barros, Naig Le Guern, Jiri Plesnik, Charles Thomas, Thibaut Bourgeois, Cornelis H.C. Dejong, Matthijs Kox, Inca H.R. Hundscheid, Naim Akhtar Khan, Stéphane Mandard, Valérie Deckert, Peter Pickkers, Daniel J. Drucker, Laurent Lagrost, Jacques Grober
Publikováno v:
Cell Reports, Vol 21, Iss 5, Pp 1160-1168 (2017)
Summary: Glucagon-like peptide 1 (GLP-1) is a hormone released from enteroendocrine L cells. Although first described as a glucoregulatory incretin hormone, GLP-1 also suppresses inflammation and promotes mucosal integrity. Here, we demonstrate that
Externí odkaz:
https://doaj.org/article/54c442ddf2554e8d93b3af382d5f41cd
Autor:
Valérie Deckert, Stéphanie Lemaire, Pierre-Jean Ripoll, Jean-Paul Pais de Barros, Jérôme Labbé, Caroline Chabert-Le Borgne, Véronique Turquois, Guillaume Maquart, Delphine Larose, Nicolas Desroche, Franck Ménétrier, Naig Le Guern, Lorène J. Lebrun, Catherine Desrumaux, Thomas Gautier, Jacques Grober, Charles Thomas, David Masson, Louis-Marie Houdebine, Laurent Lagrost
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
Abstract Although plasma phospholipid transfer protein (PLTP) has been mainly studied in the context of atherosclerosis, it shares homology with proteins involved in innate immunity. Here, we produced active recombinant human PLTP (rhPLTP) in the mil
Externí odkaz:
https://doaj.org/article/38bc086aee0d4b64bfb9adb2801c05a8
Autor:
Wahib Sali, Danish Patoli, Jean-Paul Pais de Barros, Jérôme Labbé, Valérie Deckert, Vincent Duhéron, Naig Le Guern, Denis Blache, Denis Chaumont, Eric Lesniewska, Benoit Gasquet, Catherine Paul, Mathieu Moreau, Franck Denat, David Masson, Laurent Lagrost, Thomas Gautier
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
Lipopolysaccharides (LPS) originate from the outer membrane of Gram-negative bacteria and trigger an inflammatory response via the innate immune system. LPS consist of a lipid A moiety directly responsible for the stimulation of the proinflammatory c
Externí odkaz:
https://doaj.org/article/8bced7c847df48ccae8e7cc0b244d0d3