Analysis of miRNA signatures in CSF identifies upregulation of miR-21 and miR-146a/b in patients with multiple sclerosis and active lesions

Autor: María Muñoz-San Martín, Gemma Reverter, Rene Robles-Cedeño, Maria Buxò, Francisco José Ortega, Imma Gómez, Jordi Tomàs-Roig, Naiara Celarain, Luisa María Villar, Hector Perkal, José Manuel Fernández-Real, Ester Quintana, Lluís Ramió-Torrentà

Publikováno v: Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-10 (2019)

Abstract Background MicroRNAs (miRNAs) have been reported as deregulated in active brain lesions derived from patients with multiple sclerosis (MS). In there, these post-transcriptional regulators may elicit very important effects but proper identifi

Externí odkaz: https://doaj.org/article/84c0e3228435438aa98320a4c3918032

Aberrant DNA methylation profile exacerbates inflammation and neurodegeneration in multiple sclerosis patients

Autor: Jordi Tomas-Roig, Naiara Celarain

Publikováno v: Journal of Neuroinflammation, 2020, vol. 17, art.núm.21
Articles publicats (IdIBGi)
Celarain, Naiara Tomàs Roig, Jordi 2020 Aberrant DNA methylation profile exacerbates inflammation and neurodegeneration in multiple sclerosis patients Journal of Neuroinflammation 17 art.núm.21
DUGiDocs – Universitat de Girona
instname
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-17 (2020)
Journal of Neuroinflammation

Multiple sclerosis (MS) is an autoimmune and demyelinating disease of the central nervous system characterised by incoordination, sensory loss, weakness, changes in bladder capacity and bowel function, fatigue and cognitive impairment, creating a sig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaad4d953776131d76d1b793733f7c19
http://hdl.handle.net/10256/20621

Changes in Deoxyribonucleic Acid Methylation Contribute to the Pathophysiology of Multiple Sclerosis

Autor: Jordi Tomas-Roig, Naiara Celarain

Publikováno v: Frontiers in Genetics
Frontiers in Genetics, 2019, vol. 10, art.núm. 1138
Articles publicats (IdIBGi)
Celarain, Naiara Tomàs Roig, Jordi 2019 Changes in deoxyribonucleic acid methylation contribute to the pathophysiology of multiple sclerosis Frontiers In Genetics
DUGiDocs – Universitat de Girona
instname
Frontiers in Genetics, Vol 10 (2019)

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system characterized by loss of coordination, weakness, dysfunctions in bladder capacity, bowel movement, and cognitive impairment. Thus, the disease leads to a significant socio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58c926e2d6a6378d4579a718e9372918
http://europepmc.org/articles/PMC6874160

Additional file 1: of TREM2 upregulation correlates with 5-hydroxymethycytosine enrichment in Alzheimer’s disease hippocampus

Autor: Naiara Celarain, Gordoa, Javier Sánchez-Ruiz De, Zelaya, María, Roldán, Miren, Larumbe, Rosa, Pulido, Laura, Echavarri, Carmen, Mendioroz, Maite

Contains supplemental Figure S1 (Both TREM2 splice variants showed increased mRNA expression in human hippocampus in Alzheimer’s disease), Figure S2 (Beta-amyloid and tau protein measurement in hippocampal sections) and Figure S3 (A negative contro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5eb93c17c770918bb867c8db7e3b4e5

Additional file 1: Figure S1. of CRTC1 gene is differentially methylated in the human hippocampus in Alzheimer’s disease

Autor: Mendioroz, Maite, Naiara Celarain, Altuna, Miren, Gordoa, Javier Sánchez-Ruiz De, Zelaya, María, Roldán, Miren, Rubio, Idoya, Larumbe, Rosa, Erro, María, Méndez, Iván, Echávarri, Carmen

Pictures obtained at 10x from the most representative cases showing different degrees of protein deposit. Figure S2. Beta-amyloid and tau protein measurement in hippocampal sections. Figure S3. Maps of the two CRTC1 regions analyzed by bisulfite sequ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44eab0eaada86b03641ee8ebb1e26f55