Zobrazeno 1 - 10
of 159
pro vyhledávání: '"Nai-ki Mak"'
Autor:
Yuehong Shen, Yuling Chen, Yuntao Lin, Yicun Li, Pengfei Liu, Biru Zhang, Yufan Wang, King-Chi Chan, Nai-Ki Mak, Michael Kahn, Robert Z. Qi, Hongyu Yang
Publikováno v:
Cell Death and Disease, Vol 14, Iss 2, Pp 1-11 (2023)
Abstract In oral squamous cell carcinoma (OSCC), a highly aggressive and frequently lethal malignancy, the role and action mechanism of the microtubule regulatory protein CDK5RAP2 have not been fully understood. Here, we show that CDK5RAP2 is highly
Externí odkaz:
https://doaj.org/article/22f3678e7deb4de69dfd33dd0e53ae80
Autor:
Ho-Fai Chau, Yue Wu, Wan-Yiu Fok, Waygen Thor, William Chi-Shing Cho, Ping’an Ma, Jun Lin, Nai-Ki Mak, Jean-Claude G. Bünzli, Lijun Jiang, Nicholas J. Long, Hong Lok Lung, Ka-Leung Wong
Publikováno v:
JACS Au, Vol 1, Iss 7, Pp 1034-1043 (2021)
Externí odkaz:
https://doaj.org/article/eb98c4f5f2994b63bd3fdb0401a0dedb
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82294 (2013)
Angiogenesis is a key step for tumour growth and metastasis, and anti-angiogenesis has been proposed as an important strategy for cancer therapy. Tryptanthrin is a weakly basic alkaloid isolated from the dried roots of medicinal indigo plants and has
Externí odkaz:
https://doaj.org/article/753d21d9816045bfa38318a20440da14
Autor:
Yue Liu, Ka Sin Lui, Zuodong Ye, Tsz Yan Fung, Luo Chen, Ping Yiu Sit, Chin Yu Leung, Nai Ki Mak, Ka-Leung Wong, Hong Lok Lung, Yoshimasa Tanaka, Allen Ka Loon Cheung
Publikováno v:
Theranostics. 13:458-471
Autor:
Wan-Yiu Fok, Jun Lin, Nicholas J. Long, Nai Ki Mak, Yue Wu, Waygen Thor, Lijun Jiang, Ping'an Ma, Ho-Fai Chau, Hong Lok Lung, Ka-Leung Wong, William C. Cho, Jean-Claude G. Bünzli
Publikováno v:
JACS Au
JACS Au, Vol 1, Iss 7, Pp 1034-1043 (2021)
JACS Au, Vol 1, Iss 7, Pp 1034-1043 (2021)
A lanthanide-based peptide-directed bioprobe LnP19 (Ln = Eu or Yb) is designed as an impressive example of a small molecule-based dual-functional probe for the EBV oncoprotein LMP1. The peptide P19 (Pra-KAhx-K-LDLALK-FWLY-K-IVMSDKW-K-RrRK) is designe
Autor:
Luo Chen, Yiu Chun Chiang, Lai Sheung Chan, Wai Yin Chau, Maria Li Lung, Michael Kahn, Kwok Wai Lo, Nai Ki Mak, Hong Lok Lung
Publikováno v:
Cancers; Volume 14; Issue 13; Pages: 3125
Nasopharyngeal carcinoma (NPC) is an Epstein–Barr virus (EBV)-associated malignancy ranking as the 23rd most common cancer globally, while its incidence rate ranked the 9th in southeast Asia. Tumor metastasis is the dominant cause for treatment fai
Autor:
Wai Yin Chau, Chung Hung Fong, On Ying Man, Wai Ho Shuen, Maria Li Lung, Nai Ki Mak, Hong Lok Lung, Rebecca Kan, Sai Wah Tsao
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports
Scientific Reports
We and others have previously shown that the canonical nuclear factor kappa-B (NF-κB) pathway is essential to nasopharyngeal carcinoma (NPC) tumor development and angiogenesis, suggesting that the NF-κB pathway, including its upstream modulators an
Publikováno v:
ADMET and DMPK
Volume 7
Issue 1
ADMET and DMPK, Vol 7, Iss 1, Pp 22-43 (2019)
Volume 7
Issue 1
ADMET and DMPK, Vol 7, Iss 1, Pp 22-43 (2019)
Oseltamivir phosphate (OP, Tamiflu®) is a widely used prodrug for the treatment of influenza viral infections. Orally administered OP is rapidly hydrolyzed by the carboxylesterases in animals to oseltamivir carboxylate (OC), a potent influenza virus
Autor:
Nai Ki Mak, Rotraud Wieser, Roger Kai Cheong Ngan, Sai Wah Tsao, Anne Wing Mui Lee, LS Chan, Hong Lok Lung, Michael Kahn, Kwok Wai Lo, Maria Li Lung
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 5495, p 5495 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 15
International Journal of Molecular Sciences
Volume 21
Issue 15
The Wnt signaling pathway is one of the major signaling pathways used by cancer stem cells (CSC). Ecotropic Viral Integration Site 1 (EVI1) has recently been shown to regulate oncogenic development of tumor cells by interacting with multiple signalin
Autor:
Defang Li, Tao Han, Yao Qin, Xiao-Lan Cheng, Nai Ki Mak, Sam C. K. Hau, Kai Zhang, Minjing Li, Jun Lu, Guowei Deng, Zhaohai Pan, Daniel W. J. Kwong, Kwok Keung Shiu, Xin Zhang, Jiaojiao Fan, Wang Yuzhi, Ting Yan, Qiusheng Zheng, Xiaona Liu
Publikováno v:
European journal of medicinal chemistry. 209
Photodynamic therapy (PDT) is an emerging alternative cancer treatment modality that utilizes photo-sensitivity to cause cell death upon photo-irradiation. However, PDT efficiency has been hampered by tumor hypoxia, blue-shifted excitation wavelength