Zobrazeno 1 - 10
of 502
pro vyhledávání: '"Nai Kong V. Cheung"'
Autor:
Alan W Long, Hong Xu, Brian H Santich, Hongfen Guo, Sayed Shahabuddin Hoseini, Elisa de Stanchina, Nai-Kong V Cheung
Publikováno v:
Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-17 (2024)
Abstract Background EGFR and/or HER2 expression in pancreatic cancers is correlated with poor prognoses. We generated homodimeric (EGFRxEGFR or HER2xHER2) and heterodimeric (EGFRxHER2) T cell-engaging bispecific antibodies (T-BsAbs) to direct polyclo
Externí odkaz:
https://doaj.org/article/dcaf158cf6e446219ea7f5cc9f7a96cb
Autor:
Qin Liu, Archana Thakur, Lawrence G Lum, Dana Schalk, Anthony F Shields, Daniel W Lee, Nai-Kong V Cheung, Maxim Yankelevich, Shakeel Modak, Roland Chu, Jeffrey Taub, Alissa Martin, Amy Schienshang, Sarah Whitaker, Katie Rea
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 3 (2024)
Background The survival benefit observed in children with neuroblastoma (NB) and minimal residual disease who received treatment with anti-GD2 monoclonal antibodies prompted our investigation into the safety and potential clinical benefits of anti-CD
Externí odkaz:
https://doaj.org/article/d3c0dc45f92147448b041650fe131696
Phase 1 study of intraventricular 131I-omburtamab targeting B7H3 (CD276)-expressing CNS malignancies
Autor:
Kim Kramer, Neeta Pandit-Taskar, Brian H. Kushner, Pat Zanzonico, John L. Humm, Ursula Tomlinson, Maria Donzelli, Suzanne L. Wolden, Sophia Haque, Ira Dunkel, Mark M. Souweidane, Jeffrey P. Greenfield, Satish Tickoo, Jason S. Lewis, Serge K. Lyashchenko, Jorge A. Carrasquillo, Bae Chu, Christopher Horan, Steven M. Larson, Nai-Kong V. Cheung, Shakeel Modak
Publikováno v:
Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-12 (2022)
Abstract Background The prognosis for metastatic and recurrent tumors of the central nervous system (CNS) remains dismal, and the need for newer therapeutic targets and modalities is critical. The cell surface glycoprotein B7H3 is expressed on a rang
Externí odkaz:
https://doaj.org/article/efc8fef816994f42bd7ff478e4d20251
Publikováno v:
Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-16 (2022)
Abstract A cardinal feature that distinguishes clinically high-risk neuroblastoma from low-risk tumors is telomere maintenance. Specifically, neuroblastoma tumors with either active telomerase or alternative lengthening of telomeres exhibit aggressiv
Externí odkaz:
https://doaj.org/article/2372cadc8e4f4bd1a272385fdb78b882
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundDevelopment of successful antibody-based immunotherapeutic and radioimmunotherapeutic strategies rely on the identification of cell surface tumor-associated antigens (TAA) with restricted expression on normal tissues. Desmoplastic small rou
Externí odkaz:
https://doaj.org/article/679164f905264f2cb89d6a6c7abaf612
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 3 (2023)
Background Success of T cell immunotherapy hinges on the tumor microenvironment (TME), and abnormal tumor vasculature is a hallmark of most solid tumors and associated with immune evasion. The efficacy of T cell engaging bispecific antibody (BsAb) tr
Externí odkaz:
https://doaj.org/article/17ef157b8e354f31898832bfc06a22de
Autor:
Justin W. Magrath, Dane A. Flinchum, Alifiani B. Hartono, Ilon N. Goldberg, Madelyn Espinosa-Cotton, Krzysztof Moroz, Nai-Kong V. Cheung, Sean B. Lee
Publikováno v:
Sarcoma, Vol 2023 (2023)
Desmoplastic small round cell tumor (DSRCT) is a rare pediatric cancer caused by the EWSR1-WT1 fusion oncogene. Despite initial response to chemotherapy, DSRCT has a recurrence rate of over 80% leading to poor patient prognosis with a 5-year survival
Externí odkaz:
https://doaj.org/article/975f9f0e21fe4dd3947c4d0630328ca9
Autor:
Christina Fong, Brian H. Kushner, Angela Di Giannatale, Gunes Gundem, Shanita Li, Stephen S. Roberts, Ellen M. Basu, Anita Price, Nai-Kong V. Cheung, Shakeel Modak
Publikováno v:
Frontiers in Oncology, Vol 12 (2023)
IntroductionWhile subcutaneous metastases are often observed with stage MS neuroblastoma, an entity that usually resolves spontaneously, skeletal muscle metastases (SMM) have been rarely described. The purpose of this retrospective study was to inves
Externí odkaz:
https://doaj.org/article/37a8665db9f440c883f9a21c4a57a62e
Autor:
Eun Young Yu, Syed S. Zahid, Sarah Aloe, Erik Falck-Pedersen, Xi Kathy Zhou, Nai-Kong V. Cheung, Neal F. Lue
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Yu et al. identify marked differences in the telomere and immunologic profiles of neuroblastoma cell lines displaying MES and ADRN lineage characteristics. They show that pharmacologically converting ADRN into MES cells triggers associated switch in
Externí odkaz:
https://doaj.org/article/1eeed91d3da54a22addff8ebe245c52a
Autor:
Justin W. Magrath, Hong-Jun Kang, Alifiani Hartono, Madelyn Espinosa-Cotton, Romel Somwar, Marc Ladanyi, Nai-Kong V. Cheung, Sean B. Lee
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Desmoplastic Small Round Cell Tumor (DSRCT) is a rare and aggressive pediatric cancer driven by the EWSR1-WT1 fusion oncogene. Combinations of chemotherapy, radiation and surgery are not curative, and the 5-years survival rate is less than 25%. One p
Externí odkaz:
https://doaj.org/article/67b0dde6194a40b6b6c1c882569b3d11