Rational design of an artificial tethered enzyme for non-templated post-transcriptional mRNA polyadenylation by the second generation of the C3P3 system

Autor: Marine Le Boulch, Eric Jacquet, Naïma Nhiri, Maya Shmulevitz, Philippe H. Jaïs

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-21 (2024)

Abstract We have previously introduced the first generation of C3P3, an artificial system that allows the autonomous in-vivo production of mRNA with m7GpppN-cap. While C3P3-G1 synthesized much larger amounts of capped mRNA in human cells than convent

Externí odkaz: https://doaj.org/article/17601f11857d42479a9305bebdb3dc1c

Phytochemical profile, antioxidant screening, and antidiabetic effect of pink pepper (Schinus terebinthifolius Raddi) leaves in diabetic mice

Autor: Zakia Zouaoui, Abdelmounaim Laabar, Sara El Asri, Abdelhamid Ennoury, Imad Kabach, Luigi Mondello, Francesco Cacciola, Khalid Taghzouti, Mohamed Nhiri, Naima Nhiri

Publikováno v: Journal of Agriculture and Food Research, Vol 18, Iss , Pp 101309- (2024)

This current research explores the health benefits of pink pepper (Schinus terebinthifolius Raddi) leaves linked to damage associated with diabetes in diabetic mice. An interesting increase in blood glycemia, total cholesterol, low-density lipoprotei

Externí odkaz: https://doaj.org/article/76f1244ac4f64c74845000ce009ce298

Revisiting the molecular interactions between the tumor protein TCTP and the drugs sertraline/thioridazine

Autor: Aurélien Thureau, Samir Messaoudi, Christina Sizun, Stephane Betzi, Florian Malard, Jérôme Dejeu, Amélie Chabrier, Naïma Nhiri, Eric Jacquet, Xu Zhang, Ewen Lescop

Publikováno v: ChemMedChem
ChemMedChem, Wiley-VCH Verlag, In press, ⟨10.1002/cmdc.202100528⟩
ChemMedChem, Wiley-VCH Verlag, 2021, ⟨10.1002/cmdc.202100528⟩
ChemMedChem, 2022, 17 (1), pp.e202100528. ⟨10.1002/cmdc.202100528⟩

International audience; TCTP protein is a pharmacological target in cancer and TCTP inhibitors such as sertraline have been evaluated in clinical trials. The direct interaction of TCTP with the drugs sertraline and thioridazine has been reported in v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5721da07bbb4e7f1766d65b12a32b4bf
https://hal.archives-ouvertes.fr/pasteur-03370569

Peptide deformylases from Vibrio parahaemolyticus phage and bacteria display similar deformylase activity and inhibitor binding clefts

Autor: Naïma Nhiri, Michel Desmadril, Sonia Fieulaine, Julien Nusbaum, Thierry Meinnel, Carmela Giglione, Renata Grzela, Alain Van Dorsselaer, Francesco Lavecchia, Sarah Cianférani, Eric Jacquet

Publikováno v: Biochimica et Biophysica Acta Proteins and Proteomics
Biochimica et Biophysica Acta Proteins and Proteomics, Elsevier, 2018, 1866 (2), pp.348-355. ⟨10.1016/j.bbapap.2017.10.007⟩
Biochimica et Biophysica Acta Proteins and Proteomics, 2018, 1866 (2), pp.348--355. ⟨10.1016/j.bbapap.2017.10.007⟩
Biochimica et Biophysica Acta Proteins and Proteomics, Elsevier, 2018, 1866 (2), pp.348--355. ⟨10.1016/j.bbapap.2017.10.007⟩

International audience; Unexpected peptide deformylase (PDF) genes were recently retrieved in numerous marine phage genomes. While various hypotheses dealing with the occurrence of these intriguing sequences have been made, no further characterizatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e708cd3bbf1884cfc5b7da2a201a6edd
https://doi.org/10.1016/j.bbapap.2017.10.007

Divergent HLA variations and heterogeneous expression but recurrent HLA loss-of- heterozygosity and common HLA-B and TAP transcriptional silencing across advanced pediatric solid cancers

Autor: Wan Ching Lim, Maria Eugenia Marques Da Costa, Karine Godefroy, Eric Jacquet, Loren Gragert, Windy Rondof, Antonin Marchais, Naima Nhiri, Davide Dalfovo, Mathias Viard, Nizar Labaied, Asif M. Khan, Philippe Dessen, Alessandro Romanel, Claudia Pasqualini, Gudrun Schleiermacher, Mary Carrington, Laurence Zitvogel, Jean-Yves Scoazec, Birgit Geoerger, Jerome Salmon

Publikováno v: Frontiers in Immunology, Vol 14 (2024)

The human leukocyte antigen (HLA) system is a major factor controlling cancer immunosurveillance and response to immunotherapy, yet its status in pediatric cancers remains fragmentary. We determined high-confidence HLA genotypes in 576 children, adol

Externí odkaz: https://doaj.org/article/b7bf7991e0734276842ecffd32168c0d