Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Nahum Meller"'
Autor:
Xiaoxia Z West, Nahum Meller, Nikolay L Malinin, Lalit Deshmukh, Julia Meller, Ganapati H Mahabeleshwar, Malory E Weber, Bethany A Kerr, Olga Vinogradova, Tatiana V Byzova
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31071 (2012)
Integrins mediate cell adhesion, migration, and survival by connecting intracellular machinery with the surrounding extracellular matrix. Previous studies demonstrated the importance of the interaction between β(3) integrin and VEGF type 2 receptor
Externí odkaz:
https://doaj.org/article/fbbdc593d32f40338a7c1119a3d55f44
Publikováno v:
Journal of Biological Chemistry. 286:40943-40953
Reversible protein phosphorylation is vital for many fundamental cellular processes. The actual impact of adding and removing phosphate group(s) is 3-fold: changes in the local/global geometry, alterations in the electrostatic potential and, as the r
Autor:
Nahum Meller, Hamid Deliri, Jordan Brewster, Hong Pei, Marcus D. Skaflen, Amanda C. Doran, Stephanie N. Oldham, James C. Garmey, Coleen A. McNamara, Ajay Kadakkal, Rohit Malhotra
Publikováno v:
Arterioscler Thromb Vasc Biol
Objective— To determine whether increased 12/15-lipoxygenase (12/15LO) expression in vivo enhances neointimal formation in response to injury. Methods and Results— 12/15LO expression in the vessel wall is increased in animal models of metabolic s
Autor:
R. Parker Slayton, Allison B. Lehtinen, Marcus D. Skaflen, Nahum Meller, Coleen A. McNamara, Amanda C. Doran, Stephen S. Rich, Stephanie N. Oldham, Michael J. Lipinski, Joseph Yeboah, Donald W. Bowden
Publikováno v:
Circulation Research. 106:1303-1311
Rationale : The gene encoding the helix–loop–helix transcription factor Id3 (inhibitor of differentiation-3) is located within atherosclerosis susceptibility loci of both mice and humans, yet its influence on atherosclerosis is not known. Objecti
Autor:
Coleen A. McNamara, Nahum Meller, R. Parker Slayton, Jae Bum Kim, Hamid Deliri, Stephanie N. Oldham, Amanda C. Doran, Alexis Cutchins, Susanna R. Keller
Publikováno v:
Circulation Research. 103:624-634
Adiponectin is an adipocyte-derived cytokine with beneficial effects on insulin sensitivity and the development of atherosclerosis. Id3 is a helix–loop–helix factor that binds to E-proteins such as E47 and inhibits their binding to DNA. Although
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 28:812-819
The initiation of atherosclerosis results from complex interactions of circulating factors and various cell types in the vessel wall, including endothelial cells, lymphocytes, monocytes, and smooth muscle cells (SMCs). Recent reviews highlight the ro
Publikováno v:
Biochemical Journal. 409:525-533
Rho family small GTPases are critical regulators of multiple cellular functions. Dbl-homology-domain-containing proteins are the classical GEFs (guanine nucleotide exchange factors) responsible for activation of Rho proteins. Zizimin1 is a Cdc42-spec
Emergence and subsequent functional specialization of kindlins during evolution of cell adhesiveness
Autor:
Jun Qin, Edward F. Plow, Julia Meller, Igor B. Rogozin, Eugenia Poliakov, Mark Bedanov-Pack, Eugene A. Podrez, Tatiana V. Byzova, Nahum Meller
Publikováno v:
Molecular Biology of the Cell
Kindlins are essential for integrin-mediated cell adhesion. This study focuses on the evolutionary origin and subsequent functional specialization of kindlins and their role in evolutionary adaptation of cell adhesiveness in multicellular organisms.<
Autor:
Ken-ichi Isobe, Natsuko Uekawa, Akihiko Nishikimi, Nahum Meller, Mitsuo Maruyama, Martin A. Schwartz
Publikováno v:
FEBS Letters. 579:1039-1046
A novel superfamily of guanine nucleotide exchange factors for Rho GTPases includes DOCK180 and zizimin1. The zizimin subfamily includes three genes of which only zizimin1 has been cloned. We report here the cloning of zizimin2, identified in a scree
Autor:
William B. Kiosses, Nahum Meller, Klaus M. Hahn, Nazilla B. Alderson, Miguel A. del Pozo, Martin A. Schwartz
Publikováno v:
Nature Cell Biology. 4:232-239
The proper function of Rho GTPases requires precise spatial and temporal regulation of effector interactions. Integrin-mediated cell adhesion modulates the interaction of GTP-Rac with its effectors by controlling GTP-Rac membrane targeting. Here, we