Zobrazeno 1 - 10
of 759
pro vyhledávání: '"Nahum Sonenberg"'
Publikováno v:
Molecular Brain, Vol 17, Iss 1, Pp 1-6 (2024)
Abstract The brain responds to experience through modulation of synaptic transmission, that is synaptic plasticity. An increase in the strength of synaptic transmission is manifested as long-term potentiation (LTP), while a decrease in the strength o
Externí odkaz:
https://doaj.org/article/c384dfe5e91a4758845983bb5334c5c5
Publikováno v:
Micromachines, Vol 15, Iss 8, p 1004 (2024)
Microglial cells, or brain immune cells, are highly dynamic and continuously migrate in pathophysiological conditions. Their adhesion, as a physical characteristic, plays a key role in migration. In this study, we presented a microfluidic chip combin
Externí odkaz:
https://doaj.org/article/d77ff51e818c4098b9d3125737b3a58b
Autor:
Mehdi Amiri, Stephen J. Kiniry, Anthony P. Possemato, Niaz Mahmood, Tayebeh Basiri, Catherine R. Dufour, Negar Tabatabaei, Qiyun Deng, Michael A. Bellucci, Keerthana Harwalkar, Matthew P. Stokes, Vincent Giguère, Randal J. Kaufman, Yojiro Yamanaka, Pavel V. Baranov, Soroush Tahmasebi, Nahum Sonenberg
Publikováno v:
Cell Reports, Vol 43, Iss 1, Pp 113615- (2024)
Summary: The integrated stress response (ISR) is critical for cell survival under stress. In response to diverse environmental cues, eIF2α becomes phosphorylated, engendering a dramatic change in mRNA translation. The activation of ISR plays a pivot
Externí odkaz:
https://doaj.org/article/18af2fe7b35548578596dd8ed96f88ce
Autor:
Shane Wiebe, Ziying Huang, Reese Jalal Ladak, Agnieszka Skalecka, Roberta Cagnetta, Jean-Claude Lacaille, Argel Aguilar-Valles, Nahum Sonenberg
Publikováno v:
Molecular Brain, Vol 16, Iss 1, Pp 1-13 (2023)
Abstract The consolidation of learned information into long-lasting memories requires the strengthening of synaptic connections through de novo protein synthesis. Translation initiation factors play a cardinal role in gating the production of new pro
Externí odkaz:
https://doaj.org/article/fa462c9b622c488fb6640dee8e081d75
Autor:
Samer Girgis, Zaikun Xu, Spyros Oikonomopoulos, Alla D. Fedorova, Egor P. Tchesnokov, Calvin J. Gordon, T. Martin Schmeing, Matthias Götte, Nahum Sonenberg, Pavel V. Baranov, Jiannis Ragoussis, Tom C. Hobman, Jerry Pelletier
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Genomes from defective interfering (DI) particles following serial passaging of SARS-CoV-2 reveal a fusion protein that attenuates viral replication. Synthetic, recombinant DI genomes are designed to interfere with SARS-CoV-2 replication.
Externí odkaz:
https://doaj.org/article/5e493b54c37c47c3a8ea41d5c87f53e3
Publikováno v:
European Respiratory Review, Vol 32, Iss 169 (2023)
Lymphangioleiomyomatosis (LAM) is a cystic lung disease of women resulting from mutations in tuberous sclerosis complex (TSC) genes that suppress the mammalian target of rapamycin complex 1 (mTORC1) pathway. mTORC1 activation enhances a plethora of a
Externí odkaz:
https://doaj.org/article/b4061b3adcca44b1a7374c0f3bb2694c
Autor:
Alejandra Escós, Ester Diaz-Mora, Michael Pattison, Pilar Fajardo, Diego González-Romero, Ana Risco, José Martín-Gómez, Éric Bonneil, Nahum Sonenberg, Seyed Mehdi Jafarnejad, Juan José Sanz-Ezquerro, Steven C Ley, Ana Cuenda
Publikováno v:
eLife, Vol 12 (2023)
Evidence implicating p38γ and p38δ (p38γ/p38δ) in inflammation are mainly based on experiments using Mapk12/Mapk13-deficient (p38γ/δKO) mice, which show low levels of TPL2, the kinase upstream of MKK1–ERK1/2 in myeloid cells. This could obscu
Externí odkaz:
https://doaj.org/article/465cca0c4aa64ff59473c25390cfe9f4
Autor:
Justine R. Stehn, Scott R. Floyd, Erik W. Wilker, H. Christian Reinhardt, Scott M. Clarke, Qiuying Huang, Roberto D. Polakiewicz, Nahum Sonenberg, Yi Wen Kong, Michael B. Yaffe
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
14-3-3 proteins play critical roles in controlling multiple aspects of the cellular response to stress and DNA damage including regulation of metabolism, cell cycle progression, cell migration, and apoptotic cell death by binding to protein substrate
Externí odkaz:
https://doaj.org/article/a76d35ddc948487f896db3bbbe2880e5
Autor:
Sara Hegazi, Arthur H. Cheng, Joshua J. Krupp, Takafumi Tasaki, Jiashu Liu, Daniel A. Szulc, Harrod H. Ling, Julian Rios Garcia, Shavanie Seecharran, Tayebeh Basiri, Mehdi Amiri, Zobia Anwar, Safa Ahmad, Kamar Nayal, Nahum Sonenberg, Bao-Hua Liu, Hai-Ling Margaret Cheng, Joel D. Levine, Hai-Ying Mary Cheng
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Although ubiquitin ligases are known to control clock protein degradation, their other roles in clock neurons are unclear. Here the authors report that UBR4 promotes export of neuropeptides from the Golgi for axonal trafficking, which is important fo
Externí odkaz:
https://doaj.org/article/605a3146a00649c9a7bc55bd226e5c42
Autor:
John Maringa Githaka, Namita Tripathi, Raven Kirschenman, Namrata Patel, Vrajesh Pandya, David A. Kramer, Rachel Montpetit, Lin Fu Zhu, Nahum Sonenberg, Richard P. Fahlman, Nika N. Danial, D. Alan Underhill, Ing Swie Goping
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Preventing phosphorylation of BAD (3SA) in mouse models and human cells inhibits mammary gland development, acting by disrupting 4E-BP1- mediated translation and affecting focal adhesion/protrusion stability, cell migration and ductal tubulogenesis.
Externí odkaz:
https://doaj.org/article/da9677ace6fa4ee0a7b417531c2a2ab1