Resveratrol Ameliorates Aortic Calcification in Ovariectomized Rats via SIRT1 Signaling

Autor: Sally K. Hammad, Rana G. Eissa, Mohamed A. Shaheen, Nahla N. Younis

Publikováno v: Current Issues in Molecular Biology, Vol 43, Iss 2, Pp 1057-1071 (2021)

Postmenopausal women are at an increased risk of vascular calcification which is defined as the pathological deposition of minerals in the vasculature, and is strongly linked with increased cardiovascular disease risk. Since estrogen-replacement ther

Externí odkaz: https://doaj.org/article/564318f9e43b41fd9009f638d337acbc

Vitamin D alleviates cognitive dysfunction and brain damage induced by copper sulfate intake in experimental rats: focus on its combination with donepezil

Autor: Mohamed M. Elseweidy, Mohamed Mahrous, Sousou I. Ali, Mohamed A. Shaheen, Nahla N. Younis

Publikováno v: Naunyn-Schmiedeberg's Archives of Pharmacology.

This study aimed to demonstrate the potential benefits of donepezil (DPZ) and vitamin D (Vit D) in combination to counteract the neurodegenerative disorders induced by CuSO4 intake in experimental rats. Neurodegeneration (Alzheimer-like) was induced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::abd7a4be4f997d8159b7f9f9fa0f4058
https://doi.org/10.1007/s00210-023-02449-x

Targeting wingless-integrated/β-catenin (Wnt/β-catenin) signaling pathway as a new therapeutic modality

Autor: Nahla N Younis, Hoda E. Mohamed, Asmaa M Abdelghafour, Sally K Hammad

Publikováno v: Zagazig Journal of Pharmaceutical Sciences. :1-16

Wingless-integrated/β-catenin (Wnt/β-catenin) signaling pathway is an evolutionarily conserved signaling which is not only important for regulation of embryogenesis and organ development, but also for injury repair, homeostasis and tissue remodelin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::92fdc51c16acaaf3d4f38c34fb3dde46
https://doi.org/10.21608/zjps.2021.60130.1018

Pachymic Acid Attenuated Doxorubicin-Induced Heart Failure by Suppressing miR-24 and Preserving Cardiac Junctophilin-2 in Rats

Autor: Alaa Elsayed Salama, Nahla N Younis, Rana G. Eissa, Mohamed A. Shaheen

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 10710, p 10710 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 19

Defects in cardiac contractility and heart failure (HF) are common following doxorubicin (DOX) administration. Different miRs play a role in HF, and their targeting was suggested as a promising therapy. We aimed to target miR-24, a suppressor upstrea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2da44861fa7e6e7782c0931bf39b5e41
https://www.mdpi.com/1422-0067/22/19/10710

Potential therapeutic efficacy of pachymic acid in chronic kidney disease induced in rats: role of Wnt/β-catenin/renin-angiotensin axis

Autor: Nahla N Younis, Mohamed A. Shaheen, Sally K Hammad, Hoda E. Mohamed, Asmaa M Abdelghafour

Publikováno v: The Journal of pharmacy and pharmacology. 74(1)

Objectives Chronic kidney disease (CKD) is a major public health problem associated with high mortality. The therapeutic effects of pachymic in CKD management and its underlying mechanisms have not been studied. Therefore, we aimed to investigate the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc4d5a9ee7d76af2068fc9724217d611
https://pubmed.ncbi.nlm.nih.gov/34549301