Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Nahla Galal Metwally"'
Autor:
Juliett Anders, Constantin König, Corinna Lender, Arne Hellhund, Sarah Nehls, Ibrahim Shalabi, Barbara Honecker, Stephan Lorenzen, Martin Meyer, Jenny Matthiesen, Dániel Cadar, Thomas Roeder, Nahla Galal Metwally, Hannelore Lotter, Iris Bruchhaus
Publikováno v:
PLoS Pathogens, Vol 19, Iss 12, p e1011745 (2023)
Recently, two genes involved in amoebic liver abscess formation in a mouse model were identified by their differential expression of non-pathogenic (A1np) and pathogenic (B2p) clones of the Entamoeba histolytica isolate HM:1-IMSS. While overexpressio
Externí odkaz:
https://doaj.org/article/414603f9e63c47f9893774c33897b561
Autor:
Yifan Wu, Stephanie Leyk, Hanifeh Torabi, Katharina Höhn, Barbara Honecker, Maria del Pilar Martinez Tauler, Dániel Cadar, Thomas Jacobs, Iris Bruchhaus, Nahla Galal Metwally
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107119- (2023)
Summary: Plasmodium falciparum, a human malaria parasite, develops in red blood cells (RBCs), which represent approximately 70% of all human blood cells. Additionally, RBC-derived extracellular vesicles (RBC-EVs) represent 7.3% of the total EV popula
Externí odkaz:
https://doaj.org/article/ecd89956273b4f2c80e0baf99a922a96
Autor:
Julie Sellau, Marie Groneberg, Helena Fehling, Thorsten Thye, Stefan Hoenow, Claudia Marggraff, Marie Weskamm, Charlotte Hansen, Stephanie Stanelle-Bertram, Svenja Kuehl, Jill Noll, Vincent Wolf, Nahla Galal Metwally, Sven Hendrik Hagen, Christoph Dorn, Julia Wernecke, Harald Ittrich, Egbert Tannich, Thomas Jacobs, Iris Bruchhaus, Marcus Altfeld, Hannelore Lotter
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Altered monocyte responses and testosterone levels correlate, individually, with the pathogenesis of hepatic amebiasis in mice. Here the authors show that testosterone induces enhanced TNF/CXCL1 expression and stronger proinflammatory responses in bo
Externí odkaz:
https://doaj.org/article/bb695d34b76a4b2c90047fbfce6a8c2a
Autor:
Anna Bachmann, Nahla Galal Metwally, Johannes Allweier, Jakob Cronshagen, Maria del Pilar Martinez Tauler, Agnes Murk, Lisa Katharina Roth, Hanifeh Torabi, Yifan Wu, Thomas Gutsmann, Iris Bruchhaus
Publikováno v:
Microorganisms, Vol 10, Iss 12, p 2356 (2022)
Plasmodium falciparum-infected erythrocytes (PfIEs) present P. falciparum erythrocyte membrane protein 1 proteins (PfEMP1s) on the cell surface, via which they cytoadhere to various endothelial cell receptors (ECRs) on the walls of human blood vessel
Externí odkaz:
https://doaj.org/article/28a9b00a115449fa8e6589b408a49efd
Autor:
Torben Rehn, Pedro Lubiana, Thi Huyen Trang Nguyen, Eva Pansegrau, Marius Schmitt, Lisa Katharina Roth, Jana Brehmer, Thomas Roeder, Dániel Cadar, Nahla Galal Metwally, Iris Bruchhaus
Publikováno v:
Microorganisms, Vol 10, Iss 6, p 1183 (2022)
Plasmodium falciparum-infected erythrocytes (PfIEs) adhere to endothelial cell receptors (ECRs) of blood vessels mainly via PfEMP1 proteins to escape elimination via the spleen. Evidence suggests that P. vivax-infected reticulocytes (PvIRs) also bind
Externí odkaz:
https://doaj.org/article/f2f7203b418c4deaa603b6e45a9faf41
Autor:
Constantin König, Barbara Honecker, Ian W. Wilson, Gareth D. Weedall, Neil Hall, Thomas Roeder, Nahla Galal Metwally, Iris Bruchhaus
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
The human protozoan parasite Entamoeba histolytica can live in the human intestine for months or years without generating any symptoms in the host. For unknown reasons, amoebae can suddenly destroy the intestinal mucosa and become invasive. This can
Externí odkaz:
https://doaj.org/article/b576eee8640346b186ee02cb5068ce39
Autor:
Michaela Raacke, Amy Kerr, Michael Dörpinghaus, Jana Brehmer, Yifan Wu, Stephan Lorenzen, Christine Fink, Thomas Jacobs, Thomas Roeder, Julie Sellau, Anna Bachmann, Nahla Galal Metwally, Iris Bruchhaus
Publikováno v:
Cells, Vol 10, Iss 7, p 1656 (2021)
Infections with the deadliest malaria parasite, Plasmodium falciparum, are accompanied by a strong immunological response of the human host. To date, more than 30 cytokines have been detected in elevated levels in plasma of malaria patients compared
Externí odkaz:
https://doaj.org/article/91a126fb1b8e49bf99d9e8192026e193
Autor:
Nahla Galal Metwally, Ann-Kathrin Tilly, Pedro Lubiana, Lisa K. Roth, Michael Dörpinghaus, Stephan Lorenzen, Kathrin Schuldt, Susanne Witt, Anna Bachmann, Henning Tidow, Thomas Gutsmann, Thorsten Burmester, Thomas Roeder, Egbert Tannich, Iris Bruchhaus
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract The ability of the parasite Plasmodium falciparum to evade the immune system and be sequestered within human small blood vessels is responsible for severe forms of malaria. The sequestration depends on the interaction between human endotheli
Externí odkaz:
https://doaj.org/article/42d13ef73daf4ff6bfba0bf2fa7c2781
Autor:
Constantin König, Martin Meyer, Corinna Lender, Sarah Nehls, Tina Wallaschkowski, Tobias Holm, Thorben Matthies, Dirk Lercher, Jenny Matthiesen, Helena Fehling, Thomas Roeder, Sophia Reindl, Maria Rosenthal, Nahla Galal Metwally, Hannelore Lotter, Iris Bruchhaus
Publikováno v:
Microorganisms, Vol 8, Iss 10, p 1608 (2020)
Recently, a putative alcohol dehydrogenase 3, termed EhADH3B of the Entamoeba histolytica isolate HM-1:IMSS was identified, which is expressed at higher levels in non-pathogenic than in pathogenic amoebae and whose overexpression reduces the virulenc
Externí odkaz:
https://doaj.org/article/74331464b01b4bf0bddfddb49a111b3d
Autor:
Michael Dörpinghaus, Finn Fürstenwerth, Lisa K. Roth, Philip Bouws, Maximilian Rakotonirinalalao, Vincent Jordan, Michaela Sauer, Torben Rehn, Eva Pansegrau, Katharina Höhn, Paolo Mesén-Ramírez, Anna Bachmann, Stephan Lorenzen, Thomas Roeder, Nahla Galal Metwally, Iris Bruchhaus
Publikováno v:
Microorganisms, Vol 8, Iss 2, p 174 (2020)
Changes in the erythrocyte membrane induced by Plasmodium falciparum invasion allow cytoadhesion of infected erythrocytes (IEs) to the host endothelium, which can lead to severe complications. Binding to endothelial cell receptors (ECRs) is mainly me
Externí odkaz:
https://doaj.org/article/09626296b25c4329bd458b8c1a3bbf8f