Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Nahid Saghir"'
Autor:
Paul Workman, Paul A. Clarke, Nan Chi Wan, Melanie Valenti, Stephen Shuttleworth, Peter Sheldrake, Edward McDonald, Alexander Zhyvoloup, Nahid Saghir, Anthony Robson, Giles Pergl-Wilson, Letitia Lensun, Alan T. Henley, Angela Hayes, Francesca Di Stefano, Alexis De Haven Brandon, Sharon Gowan, Adrian Folkes, Irina Chuckowree, Gary Box, Sonia Alix, Sonal Patel, Suzanne A. Eccles, Florence I. Raynaud
The phosphatidylinositide 3-kinase pathway is frequently deregulated in human cancers and inhibitors offer considerable therapeutic potential. We previously described the promising tricyclic pyridofuropyrimidine lead and chemical tool compound PI-103
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::085970df8f01140213c017be9fe8aaa7
https://doi.org/10.1158/1535-7163.c.6532217
https://doi.org/10.1158/1535-7163.c.6532217
Autor:
Paul Workman, Paul A. Clarke, Nan Chi Wan, Melanie Valenti, Stephen Shuttleworth, Peter Sheldrake, Edward McDonald, Alexander Zhyvoloup, Nahid Saghir, Anthony Robson, Giles Pergl-Wilson, Letitia Lensun, Alan T. Henley, Angela Hayes, Francesca Di Stefano, Alexis De Haven Brandon, Sharon Gowan, Adrian Folkes, Irina Chuckowree, Gary Box, Sonia Alix, Sonal Patel, Suzanne A. Eccles, Florence I. Raynaud
Supplementary Figure 1 from Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88b69a6d0bf7df52af3de6589e9ad5e0
https://doi.org/10.1158/1535-7163.22486067.v1
https://doi.org/10.1158/1535-7163.22486067.v1
Autor:
Paul Workman, Paul A. Clarke, Nan Chi Wan, Melanie Valenti, Stephen Shuttleworth, Peter Sheldrake, Edward McDonald, Alexander Zhyvoloup, Nahid Saghir, Anthony Robson, Giles Pergl-Wilson, Letitia Lensun, Alan T. Henley, Angela Hayes, Francesca Di Stefano, Alexis De Haven Brandon, Sharon Gowan, Adrian Folkes, Irina Chuckowree, Gary Box, Sonia Alix, Sonal Patel, Suzanne A. Eccles, Florence I. Raynaud
Supplementary Figure 3C from Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01c866c66e69073421c00311e11a606c
https://doi.org/10.1158/1535-7163.22486061.v1
https://doi.org/10.1158/1535-7163.22486061.v1
Autor:
Paul Workman, Paul A. Clarke, Nan Chi Wan, Melanie Valenti, Stephen Shuttleworth, Peter Sheldrake, Edward McDonald, Alexander Zhyvoloup, Nahid Saghir, Anthony Robson, Giles Pergl-Wilson, Letitia Lensun, Alan T. Henley, Angela Hayes, Francesca Di Stefano, Alexis De Haven Brandon, Sharon Gowan, Adrian Folkes, Irina Chuckowree, Gary Box, Sonia Alix, Sonal Patel, Suzanne A. Eccles, Florence I. Raynaud
Supplementary Table 1 from Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4af932823949bf9230e37a31da950e4b
https://doi.org/10.1158/1535-7163.22486052.v1
https://doi.org/10.1158/1535-7163.22486052.v1
Autor:
Paul Workman, Paul A. Clarke, Nan Chi Wan, Melanie Valenti, Stephen Shuttleworth, Peter Sheldrake, Edward McDonald, Alexander Zhyvoloup, Nahid Saghir, Anthony Robson, Giles Pergl-Wilson, Letitia Lensun, Alan T. Henley, Angela Hayes, Francesca Di Stefano, Alexis De Haven Brandon, Sharon Gowan, Adrian Folkes, Irina Chuckowree, Gary Box, Sonia Alix, Sonal Patel, Suzanne A. Eccles, Florence I. Raynaud
Supplementary Figure 2 from Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e805e180fd509a9ec2ce653e2f2de8e
https://doi.org/10.1158/1535-7163.22486064
https://doi.org/10.1158/1535-7163.22486064
Autor:
Paul Workman, Mike Waterfield, Peter Parker, Nahid Saghir, Sonal Patel, Takahide Ohishi, Tomonubu Koizumi, Hiroyuki Kaizawa, Masahiko Hayakawa, Alexis de Haven Brandon, Sharon Gowan, Lisa Patterson, Melanie Valenti, Lloyd Kelland, Lynn M. Bjerke, Sandrine Guillard, Zahida Ahmad, Francesca Di-Stefano, Alan Henley, Sonia Alix, Bernard Nutley, Angela Hayes, Paul A. Clarke, Suzanne Eccles, Florence I. Raynaud
Supplementary Figures 1-2 from Pharmacologic Characterization of a Potent Inhibitor of Class I Phosphatidylinositide 3-Kinases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::369ce14b8c8801f9d9e672b7bbcbaba5
https://doi.org/10.1158/0008-5472.22367580
https://doi.org/10.1158/0008-5472.22367580
Autor:
Paul Workman, Mike Waterfield, Peter Parker, Nahid Saghir, Sonal Patel, Takahide Ohishi, Tomonubu Koizumi, Hiroyuki Kaizawa, Masahiko Hayakawa, Alexis de Haven Brandon, Sharon Gowan, Lisa Patterson, Melanie Valenti, Lloyd Kelland, Lynn M. Bjerke, Sandrine Guillard, Zahida Ahmad, Francesca Di-Stefano, Alan Henley, Sonia Alix, Bernard Nutley, Angela Hayes, Paul A. Clarke, Suzanne Eccles, Florence I. Raynaud
Supplementary Figure Legends 1-2 from Pharmacologic Characterization of a Potent Inhibitor of Class I Phosphatidylinositide 3-Kinases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fcf46806cab9a2ae2886c96269f2566
https://doi.org/10.1158/0008-5472.22367583.v1
https://doi.org/10.1158/0008-5472.22367583.v1
Autor:
Paul Workman, Mike Waterfield, Peter Parker, Nahid Saghir, Sonal Patel, Takahide Ohishi, Tomonubu Koizumi, Hiroyuki Kaizawa, Masahiko Hayakawa, Alexis de Haven Brandon, Sharon Gowan, Lisa Patterson, Melanie Valenti, Lloyd Kelland, Lynn M. Bjerke, Sandrine Guillard, Zahida Ahmad, Francesca Di-Stefano, Alan Henley, Sonia Alix, Bernard Nutley, Angela Hayes, Paul A. Clarke, Suzanne Eccles, Florence I. Raynaud
Extensive evidence implicates activation of the lipid phosphatidylinositide 3-kinase (PI3K) pathway in the genesis and progression of various human cancers. PI3K inhibitors thus have considerable potential as molecular cancer therapeutics. Here, we d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b472982bf29403e67404aaf425b7207
https://doi.org/10.1158/0008-5472.c.6495612.v1
https://doi.org/10.1158/0008-5472.c.6495612.v1
Autor:
Adrian Folkes, Alexis De Haven Brandon, Sonal Patel, Francesca Di Stefano, Letitia Lensun, Peter Sheldrake, Alexander Zhyvoloup, Irina Chuckowree, Stephen J. Shuttleworth, Suzanne A. Eccles, Melanie Valenti, Sonia Alix, Paul A. Clarke, Nahid Saghir, Nan Chi Wan, Paul Workman, Alan T. Henley, Edward McDonald, Gary Box, Anthony Robson, Giles Pergl-Wilson, Florence I. Raynaud, Angela Hayes, Sharon Gowan
Publikováno v:
Molecular Cancer Therapeutics. 8:1725-1738
The phosphatidylinositide 3-kinase pathway is frequently deregulated in human cancers and inhibitors offer considerable therapeutic potential. We previously described the promising tricyclic pyridofuropyrimidine lead and chemical tool compound PI-103
Autor:
Suzanne A. Eccles, Pauline Moore, Lori Friedman, Paul A. Clarke, Stewart J. Baker, Olivero Alan G, Gary Box, Anthony Robson, Paul Workman, Khatereh Ahmadi, Laurent Salphati, Nahid Saghir, Giles Pergl-Wilson, Irina Chuckowree, Mark H. Ultsch, Wendy K. Alderton, Marketa Zvelebil, Florence I. Raynaud, Sukhjit Sohal, Arumugam Kugendradas, Christian Wiesmann, Adrian Folkes, Sonal Patel, Letitia Lensun, Angela Hayes, Timothy Hancox, Stephen J. Shuttleworth, Alexander Zhyvoloup, Heidi J.A. Wallweber, Paul Depledge, Melanie Valenti, Sonia Alix, Nan Chi Wan, Jodie Pang
Publikováno v:
Journal of Medicinal Chemistry. 51:5522-5532
Phosphatidylinositol-3-kinase (PI3K) is an important target in cancer due to the deregulation of the PI3K/ Akt signaling pathway in a wide variety of tumors. A series of thieno[3,2-d]pyrimidine derivatives were prepared and evaluated as inhibitors of