Výsledky vyhledávání - "Nahid Golabi"

Akademický článek

Long-read sequencing of oropharyngeal squamous cell carcinoma tumors reveal diverse patterns of high-risk Human Papillomavirus integration

Autor: Marc-Andre Gauthier, Adway Kadam, Gary Leveque, Nahid Golabi, Anthony Zeitouni, Keith Richardson, Marco Mascarella, Nader Sadeghi, Sampath Kumar Loganathan

Publikováno v: Frontiers in Oncology, Vol 13 (2023)

IntroductionIn North America and in most European countries, Human Papillomavirus (HPV) is responsible for over 70% of oropharyngeal squamous cell carcinomas. The burden of OPSCC, in high-income countries, has been steadily increasing over the past 2

Externí odkaz: https://doaj.org/article/98bf1d1e716244e18c8631cd9691833b

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Subcellular distribution and mechanism of action of AL906, a novel and potent EGFR inhibitor rationally designed to be green fluorescent

Autor: Anne-Laure Larroque, Bertrand J. Jean-Claude, Nahid Golabi, Christopher Williams, Lisa Peyrard

Publikováno v: Investigational new drugs. 39(1)

To enhance the potency of EGFR inhibitors, we developed a novel strategy that seeks to conjugate EGFR to a bioactive moiety leading to a molecule termed “combi-molecule”. In order to mimic the penetration of this type of molecules, based upon pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24dd6badc07b581217efe9b09195cd58
https://pubmed.ncbi.nlm.nih.gov/32648119

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In Vitro and In Vivo Biodistribution of ZRS1, a Stabilized Type I N-Acetoxymethyl Carbamate-Containing Combi-Molecule

Autor: Bertrand J. Jean-Claude, Ying Huang, Qiyu Qiu, Nahid Golabi, Zakaria Rachid

Publikováno v: Drug Metabolism Letters. 5:141-149

Combi-molecules are agents designed to block receptors on their own and to further degrade to bioactive agents. Here we studied the fate of a novel combi-molecule of triazene class termed “ZRS1” in biological medium using multilayer aggregates an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ea97f928acb3cdc19961e4f4f2dce22
https://doi.org/10.2174/187231211795305212

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Synthesis and Uptake of Fluorescence-Labeled Combi-molecules by P-Glycoprotein-Proficient and -Deficient Uterine Sarcoma Cells MES-SA and MES-SA/DX5

Autor: Bertrand J. Jean-Claude, Nahid Golabi, Margarita Todorova, Anne-Laure Larroque-Lombard, Christopher Williams

Publikováno v: Journal of Medicinal Chemistry. 53:2104-2113

Here, we report on the first synthesis of fluorescent-labeled epidermal growth factor receptor-DNA targeting combi-molecules, and we studied the influence of P-glycoprotein status of human sarcoma MES-SA cells on their growth inhibitory effect and ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95c3657930c449a4483b34fcd29bf02b
https://doi.org/10.1021/jm9016043

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A bioanalytical investigation on the exquisitely strong in vitro potency of the EGFR-DNA targeting type II combi-molecule ZR2003 and its mitigated in vivo antitumour activity

Autor: Zakaria Rachid, Nahid Golabi, Anne-Laure Larroque-Lombard, Ying Huang, Bertrand J. Jean-Claude, Fouad Brahimi, Qiyu Qiu

Publikováno v: Journal of pharmaceutical and biomedical analysis. 56(3)

ZR2003 is a type II of combi-molecule designed to target DNA and the epidermal growth factor receptor (EGFR) without requirement for hydrolysis. In human tumour cell lines cultured as monolayers, it showed 6.5–35 fold greater activity than Iressa.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::172863857fb9fee41c7704bec383ee48
https://pubmed.ncbi.nlm.nih.gov/21764236

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Akademický článek

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