Generation of protective pneumococcal-specific nasal resident memory CD4+ T cells via parenteral immunization

Autor: Katherine B Lucas, Joanne M O'Hara, Cynthia C. Morton, Bruce H. Horwitz, Donna L. Farber, Shorouk El Sayed, Izabel Patik, Nahid G. Robertson, Richard Malley, Evan Conaway, Claudette M. Thompson, Naresh Singh Redhu, Elaine Cheung, Muriel Herd

Publikováno v: Mucosal Immunology. 13:172-182

The generation of tissue-resident memory T cells (TRM) is an essential aspect of immunity at mucosal surfaces, and it has been suggested that preferential generation of TRM is one of the principal advantages of mucosally administered vaccines. We hav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::48fd3b04b0dcb3c97dfc776cf87ef420
https://doi.org/10.1038/s41385-019-0218-5

First Report of Bilateral External Auditory Canal Cochlin Aggregates ('Cochlinomas') with Multifocal Amyloid-Like Deposits, Associated with Sensorineural Hearing Loss and a Novel Genetic Variant in COCH Encoding Cochlin

Autor: Surendra Dasari, Nicole J. Boczek, Cynthia C. Morton, Fang Zhou, Atreyee Basu, Nahid G. Robertson, Ellen D. McPhail, Daniel Jethanamest, Paul J. Kurtin, W. Edward Highsmith, Malinda L. Butz, Samih H. Nasr

Publikováno v: Head Neck Pathol
Basu, A, Boczek, N J, Robertson, N G, Nasr, S H, Jethanamest, D, Mcphail, E D, Kurtin, P J, Dasari, S, Butz, M, Morton, C C, Highsmith, W E & Zhou, F 2020, ' First Report of Bilateral External Auditory Canal Cochlin Aggregates (“Cochlinomas”) with Multifocal Amyloid-Like Deposits, Associated with Sensorineural Hearing Loss and a Novel Genetic Variant in COCH Encoding Cochlin ', Head and Neck Pathology, vol. 14, no. 3, pp. 808-816 . https://doi.org/10.1007/s12105-019-01073-7

Pathogenic variants in COCH, encoding cochlin, cause DFNA9 deafness disorder with characteristic histopathologic findings of cochlin deposits in the inner and middle ears. Here, we present the first case of deafness associated with bilateral external

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::123ed2a7f61aa66e5d8cef3be19e9d21
https://pubmed.ncbi.nlm.nih.gov/31493294

Histopathology of the Human Inner Ear in the p.L114P COCH Mutation (DFNA9)

Autor: Jennifer T. O’Malley, Takefumi Kamakura, Joseph B. Nadol, Barbara J. Burgess, Nahid G. Robertson, Cynthia C. Morton, Kris Kristiansen

Publikováno v: Audiology and Neurotology. 21:88-97

The histopathology of the inner ear in a patient with hearing loss caused by the p.L114P COCH mutation and its correlation with the clinical phenotype are presented. To date, 23 COCH mutations causative of DFNA9 autosomal dominant sensorineural heari

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1e68316acbf9f4c3286b8393fa4e2fc3
https://doi.org/10.1159/000443822

A novel COCH mutation associated with autosomal dominant nonsyndromic hearing loss disrupts the structural stability of the vWFA2 domain

Autor: Gert Vriend, Mária Trexler, Nahid G. Robertson, Hyun-Ju Cho, Beom Sik Kang, Cynthia C. Morton, László Patthy, Kyu Yup Lee, Hong Joon Park, Hanka Venselaar, Un Kyung Kim, Jeong In Baek

Publikováno v: Journal of Molecular Medicine-Jmm, 90, 11, pp. 1321-1331
Journal of Molecular Medicine-Jmm, 90, 1321-1331

Item does not contain fulltext Mutations in COCH have been associated with autosomal dominant nonsyndromic hearing loss (DFNA9) and are frequently accompanied by vestibular hypofunction. Here, we report identification of a novel missense mutation, p.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98374e80b9c9f228774d6d573d89a8f8
https://doi.org/10.1007/s00109-012-0911-2

Hearing and vestibular deficits in the Coch null mouse model: Comparison to the Coch mouse and to DFNA9 hearing and balance disorder

Autor: Shelly Given, M. Charles Liberman, Nahid G. Robertson, Sherri M. Jones, Cynthia C. Morton, Anne Giersch

Publikováno v: Hearing Research. 272:42-48

Two mouse models, the Coch G88E/G88E or “knock-in” and the Coch −/− or “knock-out” ( Coch null), have been developed to study the human late-onset, progressive, sensorineural hearing loss and vestibular dysfunction known as DFNA9. This di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c6cc9180b61cbfe19e7096e76c653740
https://doi.org/10.1016/j.heares.2010.11.002